The San Francisco 49ers scored the most points by a team in a Week-1 game in 2021, with 41 points versus the Lions on September 12, 2021.
| TEAM | PTS | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | TD | FGM | XPM | XP2 | SFTY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 41 | 9/12/2021 | @ | W 41-33 | 2 | 2 | 1 | 5 | 2 | 5 | 0 | 0 | ||
| 2 |  | Cardinals | 38 | 9/12/2021 | @ | W 38-13 | 4 | 1 | 0 | 5 | 1 | 5 | 0 | 0 | ||
| 3 |  | Saints | 38 | 9/12/2021 | vs | W 38-3 | 5 | 0 | 0 | 5 | 1 | 5 | 0 | 0 | ||
| 4 |  | Texans | 37 | 9/12/2021 | vs | W 37-21 | 2 | 2 | 0 | 4 | 3 | 4 | 0 | 0 | ||
| 5 |  | Rams | 34 | 9/12/2021 | vs | W 34-14 | 3 | 1 | 0 | 4 | 2 | 4 | 0 | 0 | ||
| 6 |  | Raiders | 33 | 9/13/2021 | vs | W 33-27 | 2 | 2 | 0 | 4 | 2 | 3 | 0 | 0 | ||
| 7 |  | Lions | 33 | 9/12/2021 | vs | L 33-41 | 3 | 1 | 0 | 4 | 1 | 2 | 2 | 0 | ||
| 8 |  | Chiefs | 33 | 9/12/2021 | vs | W 33-29 | 3 | 1 | 0 | 4 | 2 | 3 | 0 | 0 | ||
| 9 |  | Eagles | 32 | 9/12/2021 | @ | W 32-6 | 3 | 1 | 0 | 4 | 1 | 3 | 1 | 0 | ||
| 10 |  | Buccaneers | 31 | 9/9/2021 | vs | W 31-29 | 4 | 0 | 0 | 4 | 1 | 4 | 0 | 0 | ||
| 11 |  | Browns | 29 | 9/12/2021 | @ | L 29-33 | 0 | 4 | 0 | 4 | 0 | 3 | 1 | 0 | ||
| 12 |  | Cowboys | 29 | 9/9/2021 | @ | L 29-31 | 3 | 0 | 0 | 3 | 3 | 2 | 0 | 0 | ||
| 13 |  | Seahawks | 28 | 9/12/2021 | @ | W 28-16 | 4 | 0 | 0 | 4 | 0 | 4 | 0 | 0 | ||
| 14 |  | Ravens | 27 | 9/13/2021 | @ | L 27-33 | 1 | 2 | 0 | 3 | 2 | 3 | 0 | 0 | ||
| 15 |  | Bengals | 27 | 9/12/2021 | vs | W 27-24 | 2 | 1 | 0 | 3 | 2 | 3 | 0 | 0 | ||
| 16 |  | Broncos | 27 | 9/12/2021 | @ | W 27-13 | 2 | 1 | 0 | 3 | 2 | 3 | 0 | 0 | ||
| 17 |  | Vikings | 24 | 9/12/2021 | @ | L 24-27 | 2 | 1 | 0 | 3 | 1 | 3 | 0 | 0 | ||
| 18 |  | Steelers | 23 | 9/12/2021 | @ | W 23-16 | 1 | 0 | 1 | 2 | 3 | 2 | 0 | 0 | ||
| 19 |  | Jaguars | 21 | 9/12/2021 | @ | L 21-37 | 3 | 0 | 0 | 3 | 0 | 3 | 0 | 0 | ||
| 20 |  | Chargers | 20 | 9/12/2021 | @ | W 20-16 | 1 | 1 | 0 | 2 | 2 | 2 | 0 | 0 | ||
| 21 |  | Panthers | 19 | 9/12/2021 | vs | W 19-14 | 1 | 1 | 0 | 2 | 2 | 1 | 0 | 0 | ||
| 22 |  | Dolphins | 17 | 9/12/2021 | @ | W 17-16 | 1 | 1 | 0 | 2 | 1 | 2 | 0 | 0 | ||
| 23 |  | Washington Football Team | 16 | 9/12/2021 | vs | L 16-20 | 1 | 0 | 0 | 1 | 3 | 1 | 0 | 0 | ||
| 24 |  | Colts | 16 | 9/12/2021 | vs | L 16-28 | 2 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | ||
| 25 |  | Bills | 16 | 9/12/2021 | vs | L 16-23 | 1 | 0 | 0 | 1 | 3 | 1 | 0 | 0 | ||
CHI
WAS
NYJMore 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
