The Buffalo Bills had their most points in a game against the Dolphins on September 18, 1966, with 58 points.
Interpreted as:
most points in a regular-season game scored in one game buffalo bills team history| TEAM | PTS | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | TD | FGM | XPM | XP2 | SFTY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 58 | 9/18/1966 | vs | W 58-24 | 2 | 4 | 2 | 8 | 1 | 7 | 0 | 0 | ||
| 2 | | Bills | 56 | 1/3/2021 | vs | W 56-26 | 4 | 2 | 2 | 8 | 0 | 8 | 0 | 0 | ||
| 3 | | Bills | 54 | 11/23/2008 | @ | W 54-31 | 2 | 3 | 1 | 6 | 4 | 6 | 0 | 0 | ||
| 4 | | Bills | 52 | 9/8/1991 | vs | W 52-34 | 6 | 0 | 1 | 7 | 1 | 7 | 0 | |||
| 5 | | Bills | 51 | 9/9/1979 | vs | W 51-24 | 0 | 5 | 2 | 7 | 1 | 6 | 0 | |||
| 6 | | Bills | 50 | 10/3/1976 | vs | W 50-17 | 3 | 3 | 1 | 7 | 1 | 5 | 0 | |||
| 7 | | Bills | 49 | 11/21/2010 | @ | W 49-31 | 4 | 2 | 1 | 7 | 0 | 7 | 0 | 0 | ||
| 8 | | Bills | 48 | 12/15/2024 | @ | W 48-42 | 2 | 4 | 0 | 6 | 2 | 6 | 0 | 0 | ||
| 9 | | Bills | 48 | 10/1/2023 | vs | W 48-20 | 4 | 2 | 0 | 6 | 2 | 6 | 0 | 0 | ||
| 10 | | Bills | 48 | 12/19/2020 | @ | W 48-19 | 2 | 3 | 1 | 6 | 2 | 6 | 0 | 0 | ||
| 11 | | Bills | 48 | 10/11/1964 | @ | W 48-17 | 3 | 3 | 0 | 6 | 2 | 6 | 0 | 0 | ||
| 12 | | Bills | 47 | 9/23/2024 | vs | W 47-10 | 4 | 2 | 0 | 6 | 2 | 5 | 0 | 0 | ||
| 13 | | Bills | 47 | 12/19/1993 | @ | W 47-34 | 1 | 3 | 2 | 6 | 2 | 5 | 0 | |||
| 14 | | Bills | 47 | 9/24/1989 | @ | W 47-41 | 5 | 0 | 1 | 6 | 2 | 5 | 0 | |||
| 15 | | Bills | 46 | 9/23/1979 | vs | W 46-31 | 5 | 0 | 1 | 6 | 2 | 4 | 0 | |||
| 16 | | Bills | 45 | 11/14/2021 | @ | W 45-17 | 2 | 4 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 17 | | Bills | 45 | 10/16/2016 | vs | W 45-16 | 2 | 4 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 18 | | Bills | 45 | 9/15/2002 | @ | W 45-39 | 3 | 0 | 2 | 5 | 4 | 3 | 0 | 0 | ||
| 19 | | Bills | 45 | 12/27/1998 | @ | W 45-33 | 3 | 3 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 20 | | Bills | 45 | 12/10/1995 | @ | W 45-27 | 4 | 2 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 21 | | Bills | 45 | 11/11/1990 | vs | W 45-14 | 4 | 2 | 0 | 6 | 1 | 6 | 0 | |||
| 22 | | Bills | 45 | 11/23/1975 | vs | W 45-31 | 4 | 2 | 0 | 6 | 1 | 6 | 0 | |||
| 23 | | Bills | 45 | 11/1/1970 | @ | W 45-10 | 2 | 2 | 2 | 6 | 1 | 6 | 0 | |||
| 24 | | Bills | 45 | 12/8/1963 | vs | W 45-14 | 1 | 5 | 0 | 6 | 1 | 6 | 0 | 0 | ||
| 25 | | Bills | 45 | 10/28/1962 | @ | W 45-38 | 2 | 3 | 1 | 6 | 1 | 4 | 1 | 0 | ||
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PHXMore Bills Stats
Team Leaders 
PASS
3,406
Allen
RUSH
1,532
Cook
REC
684
Shakir
Team Rankings
PPG
28.9
4th
OPP PPG
22.9
16th
RUSH YDS/G
158.9
1st
PASS YDS/G
230.7
16th
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - x | 12 | 3 | 0 | .800 |
11 | 4 | 0 | .733 | |
 Dolphins - e | 6 | 9 | 0 | .400 |
 Jets - e | 3 | 12 | 0 | .200 |
| AFC North | W | L | T | PCT |
9 | 6 | 0 | .600 | |
7 | 8 | 0 | .467 | |
 Bengals - e | 5 | 10 | 0 | .333 |
 Browns - e | 3 | 12 | 0 | .200 |
| AFC South | W | L | T | PCT |
11 | 4 | 0 | .733 | |
10 | 5 | 0 | .667 | |
8 | 6 | 0 | .571 | |
 Titans - e | 3 | 12 | 0 | .200 |
| AFC West | W | L | T | PCT |
 Broncos - x | 12 | 3 | 0 | .800 |
11 | 4 | 0 | .733 | |
 Chiefs - e | 6 | 9 | 0 | .400 |
 Raiders - e | 2 | 13 | 0 | .133 |
Ravens
Texans
Colts
Chargers| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 10 | 5 | 0 | .667 |
 Cowboys - e | 6 | 8 | 1 | .433 |
 Commanders - e | 4 | 11 | 0 | .267 |
 Giants - e | 2 | 13 | 0 | .133 |
| NFC North | W | L | T | PCT |
 Bears - x | 11 | 4 | 0 | .733 |
9 | 5 | 1 | .633 | |
8 | 7 | 0 | .533 | |
 Vikings - e | 7 | 8 | 0 | .467 |
| NFC South | W | L | T | PCT |
8 | 7 | 0 | .533 | |
7 | 8 | 0 | .467 | |
 Falcons - e | 6 | 9 | 0 | .400 |
 Saints - e | 5 | 10 | 0 | .333 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 12 | 3 | 0 | .800 |
 Rams - x | 11 | 4 | 0 | .733 |
 49ers - x | 10 | 4 | 0 | .714 |
 Cardinals - e | 3 | 12 | 0 | .200 |
Packers
Panthers
Buccaneers
