O.J. Simpson had the most rush attempts by a running back in a Week-1 game in 1975, with 32 carries against the Jets on September 21, 1975.
| NAME | ATT | DATE | TM | OPP | RUSH YDS | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 32 | 9/21/1975 | vs | 173 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 2 |  | D. Hampton | 23 | 9/21/1975 | @ | 135 | 5.9 | 2 | 0 | 0 | 0 | ||||
| 3 | | L. Mitchell | 22 | 9/21/1975 | @ | 50 | 2.3 | 0 | 49 | 5 | 9.8 | 0 | |||
| 4 | | R. Newhouse | 22 | 9/21/1975 | vs | 88 | 4.0 | 0 | 19 | 3 | 6.3 | 0 | |||
| 5 | | T. Metcalf | 20 | 9/21/1975 | vs | 99 | 5.0 | 1 | 37 | 4 | 9.3 | 0 | |||
| 6 | | L. McQuay | 20 | 9/21/1975 | vs | 47 | 2.4 | 0 | 13 | 1 | 13.0 | 0 | |||
| 7 | | R. Johnson | 20 | 9/21/1975 | @ | 49 | 2.5 | 2 | 0 | 0 | 0 | ||||
| 8 | | P. Banaszak | 19 | 9/22/1975 | @ | 74 | 3.9 | 2 | 8 | 1 | 8.0 | 0 | |||
| 9 | | A. Taylor | 19 | 9/21/1975 | @ | 60 | 3.2 | 0 | 16 | 2 | 8.0 | 0 | |||
| 10 | | B. Clark | 18 | 9/21/1975 | vs | 51 | 2.8 | 1 | 8 | 1 | 8.0 | 0 | |||
| 11 | | O. Armstrong | 18 | 9/21/1975 | vs | 82 | 4.6 | 0 | 0 | 0 | 0 | ||||
| 12 | | J. Kinney | 18 | 9/21/1975 | @ | 59 | 3.3 | 0 | 20 | 2 | 10.0 | 0 | |||
| 13 | | J. Brockington | 18 | 9/21/1975 | vs | 55 | 3.1 | 2 | 0 | 0 | 0 | ||||
| 14 | | D. Hardeman | 18 | 9/21/1975 | @ | 96 | 5.3 | 0 | 0 | 0 | 0 | ||||
| 15 | | M. Morris | 17 | 9/22/1975 | vs | 65 | 3.8 | 2 | 10 | 1 | 10.0 | 0 | |||
| 16 | | G. Pruitt | 17 | 9/21/1975 | @ | 66 | 3.9 | 1 | 4 | 2 | 2.0 | 0 | |||
| 17 | | D. Dennison | 17 | 9/21/1975 | vs | 37 | 2.2 | 1 | 0 | 0 | 0 | ||||
| 18 | | F. Harris | 17 | 9/21/1975 | @ | 78 | 4.6 | 0 | 24 | 2 | 12.0 | 0 | |||
| 19 | | J. Otis | 16 | 9/21/1975 | vs | 68 | 4.3 | 0 | 16 | 2 | 8.0 | 0 | |||
| 20 | | B. McClanahan | 16 | 9/21/1975 | vs | 61 | 3.8 | 0 | 73 | 6 | 12.2 | 1 | |||
| 21 | | S. Cunningham | 16 | 9/21/1975 | vs | 60 | 3.8 | 0 | 55 | 7 | 7.9 | 0 | |||
| 22 | | T. Sullivan | 16 | 9/21/1975 | vs | 47 | 2.9 | 0 | 44 | 4 | 11.0 | 0 | |||
| 23 | | J. Braxton | 15 | 9/21/1975 | vs | 61 | 4.1 | 0 | 3 | 1 | 3.0 | 1 | |||
| 24 | | W. Jackson | 15 | 9/21/1975 | @ | 59 | 3.9 | 0 | -2 | 2 | -1.0 | 0 | |||
| 25 | | B. Olds | 14 | 9/21/1975 | @ | 54 | 3.9 | 0 | 0 | 0 | 0 | ||||
STL
BAL
CHI
LA
HOUMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
