O.J. Simpson rushed for the most yards by a running back in a Week-2 game in 1975, with 227 yards versus the Steelers on September 28, 1975.
| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 227 | 9/28/1975 | @ | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 2 |  | J. Riggins | 145 | 9/28/1975 | @ | 27 | 5.4 | 2 | 28 | 2 | 14.0 | 0 | |||
| 3 | | C. Garrett | 135 | 9/28/1975 | @ | 16 | 8.4 | 1 | 12 | 1 | 12.0 | 0 | |||
| 4 | | D. Nottingham | 120 | 9/28/1975 | @ | 16 | 7.5 | 1 | -2 | 1 | -2.0 | 0 | |||
| 5 | | R. Coleman | 112 | 9/28/1975 | vs | 16 | 7.0 | 1 | 0 | 0 | 0 | ||||
| 6 | | D. Hardeman | 107 | 9/28/1975 | vs | 27 | 4.0 | 1 | 0 | 0 | 0 | ||||
| 7 |  | W. Payton | 95 | 9/28/1975 | vs | 21 | 4.5 | 0 | 36 | 6 | 6.0 | 0 | |||
| 8 | | R. Newhouse | 90 | 9/28/1975 | vs | 23 | 3.9 | 0 | -1 | 1 | -1.0 | 0 | |||
| 9 | | D. Hampton | 86 | 9/28/1975 | vs | 21 | 4.1 | 0 | 0 | 1 | 0.0 | 0 | |||
| 10 | | J. Otis | 86 | 9/28/1975 | @ | 23 | 3.7 | 0 | 5 | 1 | 5.0 | 0 | |||
| 11 | | F. Harris | 84 | 9/28/1975 | vs | 18 | 4.7 | 2 | 10 | 3 | 3.3 | 0 | |||
| 12 | | J. Braxton | 80 | 9/28/1975 | @ | 14 | 5.7 | 0 | 2 | 1 | 2.0 | 0 | |||
| 13 | | M. van Eeghen | 68 | 9/28/1975 | @ | 15 | 4.5 | 0 | -2 | 1 | -2.0 | 0 | |||
| 14 | | L. Schreiber | 67 | 9/28/1975 | vs | 19 | 3.5 | 0 | 24 | 6 | 4.0 | 0 | |||
| 15 | | L. McCutcheon | 66 | 9/28/1975 | @ | 19 | 3.5 | 0 | 59 | 5 | 11.8 | 1 | |||
| 16 | | M. Thomas | 64 | 9/28/1975 | vs | 12 | 5.3 | 0 | 13 | 2 | 6.5 | 0 | |||
| 17 | | A. Taylor | 63 | 9/28/1975 | @ | 16 | 3.9 | 1 | 0 | 0 | 0 | ||||
| 18 | | B. McClanahan | 61 | 9/28/1975 | @ | 12 | 5.1 | 0 | 8 | 1 | 8.0 | 0 | |||
| 19 | | D. Woods | 60 | 9/28/1975 | @ | 16 | 3.8 | 1 | 18 | 2 | 9.0 | 0 | |||
| 20 | | J. Keyworth | 59 | 9/29/1975 | vs | 14 | 4.2 | 0 | 9 | 1 | 9.0 | 0 | |||
| 21 | | E. Podolak | 53 | 9/28/1975 | vs | 11 | 4.8 | 1 | 54 | 5 | 10.8 | 0 | |||
| 22 | | G. Pruitt | 50 | 9/28/1975 | vs | 11 | 4.5 | 0 | 2 | 2 | 1.0 | 0 | |||
| 23 | | T. Sullivan | 49 | 9/28/1975 | @ | 11 | 4.5 | 0 | 47 | 5 | 9.4 | 0 | |||
| 24 | | J. Kinney | 48 | 9/28/1975 | vs | 9 | 5.3 | 0 | 26 | 5 | 5.2 | 0 | |||
| 25 | | M. Morris | 47 | 9/28/1975 | @ | 14 | 3.4 | 0 | 0 | 0 | 0 | ||||
HOU
CHI
STL
BAL
LA
WASMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
