Eric Dickerson has the most carries by a rookie, with 390 rush attempts in 1983.

most rushing attempts by a rookie
1983Dickerson1981Rogers1999James1995Martin2001Tomlinson2012Morris1996George1983Warner1979Anderson2016Elliott2012Martin2008Forte1994Faulk1980Sims2000Lewis2021Harris1996al-Jabbar1980Cribbs1978Campbell2000Anderson1988Stephens1995Salaam390378369368339335335335331322319316314313309307307306302297297296
NAMESEASONTMGPATTRUSH YDSYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
Eric DickersonEric Dickerson1983
RAMRAM
163901,8084.6113.018404517.925.32
George RogersGeorge Rogers1981
NONO
163781,6744.4104.613126167.97.90
Edgerrin JamesEdgerrin James1999
INDIND
163691,5534.297.11358662879.536.64
Curtis MartinCurtis Martin1995
NENE
163681,4874.092.914261308.716.31
LaDainian TomlinsonLaDainian Tomlinson2001
SDSD
163391,2363.677.31036759746.222.90
Alfred MorrisAlfred Morris2012
WASWAS
163351,6134.8100.8137711167.04.80
Eddie GeorgeEddie George1996
HOUHOU
163351,3684.185.58182237.911.40
Curt WarnerCurt Warner1983
SEASEA
163351,4494.390.613325427.720.31
Ottis AndersonOttis Anderson1979
STLSTL
163311,6054.8100.38308417.519.32
Ezekiel ElliottEzekiel Elliott2016
DALDAL
153221,6315.1108.715363324011.324.21
Doug MartinDoug Martin2012
TBTB
163191,4544.690.91147249709.629.51
Matt ForteMatt Forte2008
CHICHI
163161,2383.977.4847763767.629.84
Marshall FaulkMarshall Faulk1994
INDIND
163141,2824.180.1115225210.032.61
Billy SimsBilly Sims1980
DETDET
163131,3034.281.4136215112.238.83
Jamal LewisJamal Lewis2000
BALBAL
163091,3644.485.36296273611.018.50
Najee HarrisNajee Harris2021
PITPIT
173071,2003.970.6746774946.327.53
Abdul-Karim al-JabbarAbdul-Karim al-Jabbar1996
MIAMIA
163071,1163.669.811139236.08.70
Joe CribbsJoe Cribbs1980
BUFBUF
163061,1853.974.111415528.025.91
Earl CampbellEarl Campbell1978
HOUHOU
153021,4504.896.71348124.03.20
Mike AndersonMike Anderson2000
DENDEN
162971,4875.092.91516923327.310.60
John StephensJohn Stephens1988
NENE
162971,1683.973.0498147.06.10
Rashaan SalaamRashaan Salaam1995
CHICHI
162961,0743.667.1105678.03.50
Jerome BettisJerome Bettis1993
RAMRAM
162941,4294.989.37244269.415.30
Bobby HumphreyBobby Humphrey1989
DENDEN
162941,1513.971.97156227.19.81
Robert EdwardsRobert Edwards1998
NENE
162911,1153.869.79331359.520.73
StatMuse has season-level data for rush attempts going back to the 1932 season.