O.J. Simpson has the most rushing yards by a running back in a game on Thursdays, with 273 yards against the Lions on November 25, 1976.
| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 2 |  | C. Dillon | 246 | 12/4/1997 | vs | 39 | 6.3 | 4 | 30 | 2 | 15.0 | 0 | |||
| 3 |  | D. Henry | 238 | 12/6/2018 | vs | 17 | 14.0 | 4 | 0 | 0 | 0 | 0 | |||
| 4 | | W. Parker | 223 | 12/7/2006 | vs | 32 | 7.0 | 1 | 0 | 0 | 1 | 0 | |||
| 5 |  | D. Cook | 205 | 12/9/2021 | vs | 27 | 7.6 | 2 | 17 | 1 | 3 | 17.0 | 0 | ||
| 6 | | E. George | 199 | 12/9/1999 | vs | 28 | 7.1 | 2 | 50 | 6 | 8 | 8.3 | 0 | ||
| 7 | | B. Hoernschemeyer | 198 | 11/23/1950 | vs | 17 | 11.6 | 1 | |||||||
| 8 | | E. Campbell | 195 | 11/22/1979 | @ | 33 | 5.9 | 2 | 0 | 0 | 0 | ||||
| 9 |  | B. Robinson | 194 | 9/24/2026 | @ | 29 | 6.7 | 2 | 19 | 2 | 2 | 9.5 | 0 | ||
| 10 |  | D. Murray | 179 | 12/4/2014 | @ | 32 | 5.6 | 1 | 49 | 9 | 10 | 5.4 | 0 | ||
| 11 |  | W. Payton | 179 | 11/26/1981 | @ | 38 | 4.7 | 0 | 4 | 2 | 2.0 | 0 | |||
| 12 |  | D. Swift | 175 | 9/14/2023 | vs | 28 | 6.3 | 1 | 6 | 3 | 3 | 2.0 | 0 | ||
| 13 |  | J. Taylor | 172 | 11/4/2021 | vs | 19 | 9.1 | 2 | 28 | 2 | 2 | 14.0 | 0 | ||
| 14 |  | C. Akers | 171 | 12/10/2020 | vs | 29 | 5.9 | 0 | 23 | 2 | 3 | 11.5 | 0 | ||
| 15 |  | B. Sanders | 167 | 11/27/1997 | vs | 19 | 8.8 | 3 | 8 | 2 | 4.0 | 0 | |||
| 16 |  | B. Irving | 165 | 10/8/2026 | @ | 21 | 7.9 | 1 | 10 | 2 | 3 | 5.0 | 1 | ||
| 17 | | J. Braxton | 160 | 11/27/1975 | @ | 34 | 4.7 | 3 | 33 | 3 | 11.0 | 0 | |||
| 18 |  | L. McCoy | 159 | 11/27/2014 | @ | 25 | 6.4 | 1 | 0 | 0 | 0 | 0 | |||
| 19 | | C.J. Anderson | 158 | 12/14/2017 | @ | 30 | 5.3 | 0 | 0 | 0 | 1 | 0 | |||
| 20 | | L. McCoy | 158 | 9/19/2013 | vs | 20 | 7.9 | 1 | 0 | 0 | 1 | 0 | |||
| 21 | | A. Foster | 158 | 12/22/2011 | @ | 23 | 6.9 | 1 | 16 | 3 | 3 | 5.3 | 0 | ||
| 22 |  | D. Johnson | 157 | 10/6/2016 | @ | 27 | 5.8 | 2 | 28 | 3 | 6 | 9.3 | 0 | ||
| 23 | | M. Bush | 157 | 11/10/2011 | @ | 30 | 5.2 | 1 | 85 | 3 | 4 | 28.3 | 0 | ||
| 24 | | L. Johnson | 157 | 11/23/2006 | vs | 34 | 4.6 | 1 | 6 | 1 | 3 | 6.0 | 0 | ||
| 25 | | A. Haynes | 157 | 11/24/1960 | @ | 11 | 14.3 | 2 | 3 | 1 | 3.0 | 0 | |||
BUF
DET
CIN
TEN
TEN
JAX
PIT
CLE
MIN
OAK
NYY
HOU
DAL
ATL
GB
CHI
PHI
IND
NYJ
LAR
NE
TB
STL
DEN
KC
HOU
ARI
SF
SD
NYTResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More NFL News
Eagles and Commanders make poor decisions that cost them wins during tough week for NFC East
Huntley leads late TD drive to force OT and then scores on 1-yard run as Ravens beat Falcons 30-23
Falcons' Michael Penix Jr. sustains rib injury in 4th quarter in OT loss to Ravens
Falcons sacks king John Abraham has former coach Mike Smith return to lead ring of honor ceremony
Jaxon Smith-Njigba's drop and 4 turnovers hurt the Seahawks in their loss to the 49ers
Broncos' struggles on offense continue in Sean Payton's return to play-calling
More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
2nd
OPP PPG
26.8
25th
RUSH YDS/G
139.0
6th
PASS YDS/G
259.8
10th
Dolphins
BAL
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Commanders
Bears
Panthers
Saints
Seahawks| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |