most scrimmage yards by running back in a game 2021

Derrick Henry gained the most yards from scrimmage by a running back in a game in 2021, with 237 yards against the Seahawks on September 19, 2021.

Interpreted as:

most scrimmage yards by running back in a regular-season game 2021

	NAME	YDS	DATE	TM		OPP	RUSH YDS	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	Derrick Henry D. Henry	237	9/19/2021	TEN	@	SEA	182	35	5.2	3	55	6	6	9.2	0
2	Dalvin Cook D. Cook	222	12/9/2021	MIN	vs	PIT	205	27	7.6	2	17	1	3	17.0	0
3	Najee Harris N. Harris	206	1/3/2022	PIT	vs	CLE	188	28	6.7	1	18	3	3	6.0	0
4	Jonathan Taylor J. Taylor	204	11/21/2021	IND	@	BUF	185	32	5.8	4	19	3	3	6.3	1
5	Jonathan Taylor J. Taylor	200	11/4/2021	IND	vs	NYJ	172	19	9.1	2	28	2	2	14.0	0
6	Rashaad Penny R. Penny	190	1/9/2022	SEA	@	ARI	190	23	8.3	1	0	0	0		0
7	Christian McCaffrey C. McCaffrey	187	9/12/2021	CAR	vs	NYJ	98	21	4.7	0	89	9	9	9.9	0
8	Rashaad Penny R. Penny	185	1/2/2022	SEA	vs	DET	170	25	6.8	2	15	2	3	7.5	0
9	Nick Chubb N. Chubb	184	12/25/2021	CLE	@	GB	126	17	7.4	1	58	3	4	19.3	0
10	Alvin Kamara A. Kamara	179	10/25/2021	NO	@	SEA	51	20	2.6	0	128	10	11	12.8	1
11	Javonte Williams J. Williams	178	12/5/2021	DEN	@	KC	102	23	4.4	0	76	6	9	12.7	1
12	Derrick Henry D. Henry	177	10/3/2021	TEN	@	NYJ	157	33	4.8	1	20	2	2	10.0	0
13	James Conner J. Conner	173	11/7/2021	ARI	@	SF	96	21	4.6	2	77	5	5	15.4	1
14	Michael Carter M. Carter	172	10/31/2021	NYJ	vs	CIN	77	15	5.1	1	95	9	14	10.6	0
15	Alexander Mattison A. Mattison	171	9/26/2021	MIN	vs	SEA	112	26	4.3	0	59	6	8	9.8	0
16	Jonathan Taylor J. Taylor	170	12/18/2021	IND	vs	NE	170	29	5.9	1	0	0	0		0
17	Nick Chubb N. Chubb	170	10/10/2021	CLE	@	LAC	161	21	7.7	1	9	1	1	9.0	0
18	Jonathan Taylor J. Taylor	169	10/11/2021	IND	@	BAL	53	15	3.5	1	116	3	4	38.7	1
19	Elijah Mitchell E. Mitchell	168	11/28/2021	SF	vs	MIN	133	27	4.9	1	35	5	6	7.0	0
20	D'Ernest Johnson D. Johnson	168	10/21/2021	CLE	vs	DEN	146	22	6.6	1	22	2	2	11.0	0
21	Joe Mixon J. Mixon	163	11/28/2021	CIN	vs	PIT	165	28	5.9	2	-2	4	4	-0.5	0
22	Nick Chubb N. Chubb	163	11/7/2021	CLE	@	CIN	137	14	9.8	2	26	2	2	13.0	0
23	Alvin Kamara A. Kamara	162	1/9/2022	NO	@	ATL	146	30	4.9	0	16	2	2	8.0	0
24	Justin Jackson J. Jackson	162	12/26/2021	LAC	@	HOU	64	11	5.8	2	98	8	9	12.3	0
25	Christian McCaffrey C. McCaffrey	161	11/14/2021	CAR	@	ARI	95	13	7.3	0	66	10	10	6.6	0

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Opp PPG Rankings

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Total Yards Rankings

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Rush Yards Rankings

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Pass Yards Rankings

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McCaffrey

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Nacua

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Smith-Njigba

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Fantasy TE Rankings

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NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176