T.J. Watt and Nick Bosa were tied for the most tackles for loss in 2021, with 21 tackles.

Interpreted as:

most tackle for loss by a player 2021 season

	NAME	TFL	SEASON	TM	GP	TKL	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	T.J. Watt	21	2021	PIT	15	48	16	64	22.5	111.5	0	0	0	5	3	0
2	Nick Bosa N. Bosa	21	2021	SF	17	40	12	52	15.5	122	0	0	0	4	0	0
3	Micah Parsons M. Parsons	20	2021	DAL	16	64	20	84	13.0	119.5	0	0	0	3	0	0
4	Von Miller V. Miller	19	2021	TOT	15	33	17	50	9.5	56	0	0	0	1	0	0
5	Aaron Donald A. Donald	19	2021	LAR	17	38	46	84	12.5	111	0	0	0	4	0	0
6	Robert Quinn R. Quinn	17	2021	CHI	16	38	11	49	18.5	133.5	0	0	0	4	0	0
7	Myles Garrett M. Garrett	17	2021	CLE	17	33	18	51	16.0	91.5	0	0	0	1	1	1
8	Cameron Heyward C. Heyward	15	2021	PIT	17	53	36	89	10.0	55.5	1	0	0	1	1	0
9	Matt Milano M. Milano	15	2021	BUF	16	57	29	86	3.0	27	0	0	0	0	2	0
10	Alex Highsmith A. Highsmith	15	2021	PIT	16	46	28	74	6.0	35.5	0	0	0	1	0	0
11	Matthew Judon M. Judon	14	2021	NE	17	38	22	60	12.5	85	0	0	0	0	1	0
12	Harold Landry III H. Landry III	14	2021	TEN	17	51	24	75	12.0	80	0	0	0	1	0	0
13	Demario Davis D. Davis	13	2021	NO	16	70	35	105	3.0	16	0	0	0	0	0	0
14	Cameron Jordan C. Jordan	13	2021	NO	16	38	21	59	12.5	75.5	0	0	0	2	0	0
15	Kamu Grugier-Hill K. Grugier-Hill	13	2021	HOU	14	71	37	108	3.0	20	1	82	0	2	0	0
16	Roquan Smith R. Smith	13	2021	CHI	17	95	68	163	3.0	25	1	53	1	0	0	0
17	Maxx Crosby M. Crosby	13	2021	LV	17	36	20	56	8.0	52.5	0	0	0	0	0	0
18	Brian Burns B. Burns	13	2021	CAR	17	31	19	50	9.0	78	0	0	0	2	0	0
19	Chandler Jones C. Jones	12	2021	ARI	15	31	10	41	10.5	79.5	0	0	0	6	1	0
20	Trey Hendrickson T. Hendrickson	12	2021	CIN	16	20	14	34	14.0	96.5	0	0	0	3	0	0
21	Larry Ogunjobi L. Ogunjobi	12	2021	CIN	16	29	20	49	7.0	51.5	0	0	0	0	0	0
22	Haason Reddick H. Reddick	12	2021	CAR	16	37	31	68	11.0	72.5	0	0	0	2	1	0
23	Sam Hubbard S. Hubbard	12	2021	CIN	16	33	29	62	7.5	32	0	0	0	1	2	0
24	Jeffery Simmons J. Simmons	12	2021	TEN	17	42	12	54	8.5	64.5	0	0	0	0	0	0
25	Josh Hines-Allen J. Hines-Allen	12	2021	JAX	16	46	25	71	7.5	70	1	11	0	1	1	0

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StatMuse has season-level data for tackles for loss going back to the 2001 season.

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T.J. Watt and Nick Bosa were tied for the most tackles for loss in 2021, with 21 tackles.

Interpreted as:

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