Michael Strahan has the most sacks by a defensive lineman in a season, with 22.5 sacks in 2001.

Interpreted as:

NFL most defensive sacks for a de in a season

	NAME	SCK	SEASON	TM	GP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Michael Strahan M. Strahan	22.5	2001	NYG	16	61	12	73	177.5	0	0	0	6	1	1
2	Myles Garrett M. Garrett	22.0	2025	CLE	15	41	17	58	160	0	0	0	3	0	0
3	Jared Allen J. Allen	22.0	2011	MIN	16	48	18	66	150.5	1	14	0	4	4	0
4	Mark Gastineau M. Gastineau	22.0	1984	NYJ	16					0	0	0		1	1
5	Chris Doleman C. Doleman	21.0	1989	MIN	16					0	0	0		5	0
6	Reggie White R. White	21.0	1987	PHI	12					0	0	0		1	1
7	Aaron Donald A. Donald	20.5	2018	LAR	16	41	18	59	183.5	0	0	0	4	2	0
8	J.J. Watt	20.5	2014	HOU	16	59	19	78	140	1	80	1	4	5	1
9	J.J. Watt	20.5	2012	HOU	16	69	12	81	138.5	0	0	0	4	2	0
10	Robert Mathis R. Mathis	19.5	2013	IND	16	44	15	59	120.5	0	0	0	8	0	0
11	Robert Quinn R. Quinn	19.0	2013	STL	16	50	7	57	145	0	0	0	7	2	1
12	Clyde Simmons C. Simmons	19.0	1992	PHI	16					0	0	0		1	0
13	Bruce Smith B. Smith	19.0	1990	BUF	16					0	0	0		0	0
14	Mark Gastineau M. Gastineau	19.0	1983	NYJ	16					0	0	0		2	1
15	Nick Bosa N. Bosa	18.5	2022	SF	16	41	10	51	137.5	0	0	0	2	0	0
16	Michael Strahan M. Strahan	18.5	2003	NYG	16	60	15	75	126.5	0	0	0	3	1	0
17	Jason Taylor J. Taylor	18.5	2002	MIA	16	46	24	70	162.5	0	0	0	7	2	0
18	Dexter Manley D. Manley	18.5	1986	WAS	16					0	0	0		1	1
19	Jason Babin J. Babin	18.0	2011	PHI	16	35	5	40	107	0	0	0	3	0	0
20	Keith Millard K. Millard	18.0	1989	MIN	16					1	48	0		1	1
21	Reggie White R. White	18.0	1988	PHI	16					0	0	0		2	0
22	Reggie White R. White	18.0	1986	PHI	16					0	0	0		0	0
23	Trey Hendrickson T. Hendrickson	17.5	2024	CIN	17	33	13	46	125.5	0	0	0	2	0	0
24	Trey Hendrickson T. Hendrickson	17.5	2023	CIN	17	28	15	43	121.5	0	0	0	3	0	0
25	J.J. Watt	17.5	2015	HOU	16	57	19	76	117.5	0	0	0	3	1	0

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StatMuse has season-level data for sacks going back to the 1982 season.

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Sun 12/28	NYG	@	LV	4:05 PM
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Bills - x	11	4	0	.733
Dolphins - e	6	9	0	.400
Jets - e	3	12	0	.200
AFC North	W	L	T	PCT
Steelers	9	6	0	.600
Ravens	7	8	0	.467
Bengals - e	5	10	0	.333
Browns - e	3	12	0	.200
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Texans	10	5	0	.667
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Lions	8	7	0	.533
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Buccaneers	7	8	0	.467
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Rams - x	11	4	0	.733
Cardinals - e	3	12	0	.200