The Buffalo All-Americans have the highest point differential by a team in a Week-4 game, with a 57-point differential versus the Oorang Indians on October 21, 1923.
| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | All-Americans | 57 | 10/21/1923 |  BUF | vs |  OOR | W 57-0 | ||||||
| 2 | | All-Americans | 55 | 10/16/1921 | BUF | vs | NYG | W 55-0 | ||||||
| 3 |  | Chiefs | 45 | 9/28/1968 |  KC | @ |  MIA | W 48-3 | 6 | 17 | 431 | 234 | ||
| 4 |  | Eagles | 45 | 10/10/1948 |  PHI | vs |  NYG | W 45-0 | 6 | 19 | ||||
| 5 |  | Triangles | 44 | 10/17/1920 |  DAY | vs |  HAM | W 44-0 | ||||||
| 6 |  | Texans | 43 | 10/1/2017 |  HOU | vs |  TEN | W 57-14 | 7 | 33 | 445 | 195 | 50.0 | 100.0 |
| 7 |  | Colts | 43 | 10/10/1971 |  BAL | @ |  BUF | W 43-0 | 5 | 19 | 401 | 49 | ||
| 8 |  | Cardinals | 42 | 10/6/1963 |  STL | @ |  MIN | W 56-14 | 8 | 26 | 520 | 218 | ||
| 9 |  | Browns | 42 | 10/19/1952 |  CLE | @ | PHI | W 49-7 | 7 | 28 | 507 | 162 | ||
| 10 | | Chiefs | 41 | 10/1/2006 | KC | vs |  SF | W 41-0 | 5 | 23 | 333 | 165 | 53.3 | |
| 11 |  | Colts | 41 | 10/4/1987 |  IND | @ | BUF | W 47-6 | 6 | 28 | 463 | 163 | ||
| 12 | | Browns | 41 | 10/16/1960 | CLE | @ |  DLC | W 48-7 | 7 | 18 | 282 | 167 | ||
| 13 |  | Bulldogs | 41 | 10/13/1929 |  BOS | vs | DAY | W 41-0 | ||||||
| 14 |  | Bills | 40 | 10/3/2021 | BUF | vs | HOU | W 40-0 | 4 | 26 | 450 | 109 | 41.7 | 50.0 |
| 15 |  | Patriots | 39 | 10/6/1974 |  NE | vs | BAL | W 42-3 | 6 | 23 | 384 | 265 | ||
| 16 |  | Rams | 39 | 10/18/1959 |  LA | @ |  GB | W 45-6 | 5 | 23 | 456 | 262 | ||
| 17 |  | Bears | 38 | 9/30/2018 |  CHI | vs |  TB | W 48-10 | 6 | 28 | 483 | 311 | 50.0 | |
| 18 |  | Jets | 38 | 9/26/1993 |  NYJ | vs | NE | W 45-7 | 6 | 21 | 388 | 211 | 57.1 | |
| 19 |  | Packers | 38 | 10/8/1961 | GB | vs | BAL | W 45-7 | 6 | 25 | 357 | 289 | ||
| 20 |  | Ravens | 37 | 9/24/2000 |  BAL | vs |  CIN | W 37-0 | 4 | 27 | 391 | 94 | 70.6 | 0.0 |
| 21 | | Bears | 37 | 9/28/1986 | CHI | @ | CIN | W 44-7 | 6 | 23 | 476 | 338 | ||
| 22 |  | Dolphins | 37 | 9/23/1984 | MIA | vs | IND | W 44-7 | 6 | 24 | 399 | 223 | ||
| 23 | | Eagles | 36 | 10/7/1950 | PHI | vs | LA | W 56-20 | 8 | 20 | 473 | 455 | ||
| 24 |  | Cowboys | 35 | 10/1/2023 | DAL | vs | NE | W 38-3 | 4 | 22 | 377 | 253 | 53.3 | 0.0 |
| 25 |  | 49ers | 35 | 10/4/2009 | SF | vs |  STL | W 35-0 | 5 | 13 | 228 | 177 | 30.8 | |
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
| Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
| Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
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