The San Francisco 49ers have a 10-11 record against the AFC in the regular-season and playoffs since 2021.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/24/2021 | 0-1 |  SF | vs |  IND | L 18-30 | .000 | 2 | 13 | 280 | 295 | 9.1 | |
| 2 | | 49ers | 11/21/2021 | 1-0 | SF | @ |  JAX | W 30-10 | 1.000 | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 3 | | 49ers | 12/12/2021 | 1-0 | SF | @ |  CIN | W 26-23 | 1.000 | 3 | 21 | 355 | 397 | 33.3 | |
| 4 | | 49ers | 12/23/2021 | 0-1 | SF | @ |  TEN | L 17-20 | .000 | 2 | 22 | 389 | 278 | 37.5 | 50.0 |
| 5 | | 49ers | 1/2/2022 | 1-0 | SF | vs |  HOU | W 23-7 | 1.000 | 2 | 19 | 416 | 222 | 38.5 | 0.0 |
| 6 | | 49ers | 9/25/2022 | 0-1 | SF | @ |  DEN | L 10-11 | .000 | 1 | 13 | 267 | 261 | 10.0 | |
| 7 | | 49ers | 10/23/2022 | 0-1 | SF | vs |  KC | L 23-44 | .000 | 2 | 25 | 444 | 529 | 57.1 | |
| 8 | | 49ers | 11/13/2022 | 1-0 | SF | vs |  LAC | W 22-16 | 1.000 | 2 | 22 | 387 | 238 | 52.9 | 100.0 |
| 9 | | 49ers | 12/4/2022 | 1-0 | SF | vs |  MIA | W 33-17 | 1.000 | 3 | 24 | 351 | 308 | 42.1 | 50.0 |
| 10 | | 49ers | 1/1/2023 | 1-0 | SF | @ |  LV | W 37-34 | 1.000 | 4 | 27 | 454 | 500 | 50.0 | |
| 11 | | 49ers | 9/10/2023 | 1-0 | SF | @ |  PIT | W 30-7 | 1.000 | 3 | 22 | 391 | 239 | 46.2 | 100.0 |
| 12 | | 49ers | 10/15/2023 | 0-1 | SF | @ |  CLE | L 17-19 | .000 | 2 | 15 | 215 | 334 | 25.0 | |
| 13 | | 49ers | 10/29/2023 | 0-1 | SF | vs | CIN | L 17-31 | .000 | 2 | 24 | 460 | 400 | 55.6 | |
| 14 | | 49ers | 11/12/2023 | 1-0 | SF | @ | JAX | W 34-3 | 1.000 | 4 | 20 | 437 | 221 | 33.3 | 50.0 |
| 15 | | 49ers | 12/25/2023 | 0-1 | SF | vs |  BAL | L 19-33 | .000 | 2 | 21 | 429 | 343 | 42.9 | 33.3 |
| 16 | | 49ers | 2/11/2024 | 0-1 | SF | @ | KC | L 22-25 | .000 | 2 | 23 | 382 | 455 | 25.0 | 100.0 |
| 17 | | 49ers | 9/9/2024 | 1-0 | SF | vs |  NYJ | W 32-19 | 1.000 | 2 | 24 | 401 | 266 | 46.2 | |
| 18 | | 49ers | 9/29/2024 | 1-0 | SF | vs |  NE | W 30-13 | 1.000 | 3 | 19 | 431 | 216 | 53.8 | |
| 19 | | 49ers | 10/20/2024 | 0-1 | SF | vs | KC | L 18-28 | .000 | 2 | 19 | 310 | 329 | 18.2 | 100.0 |
| 20 | | 49ers | 12/1/2024 | 0-1 | SF | @ |  BUF | L 10-35 | .000 | 1 | 15 | 239 | 372 | 30.0 | 100.0 |
| 21 | | 49ers | 12/22/2024 | 0-1 | SF | @ | MIA | L 17-29 | .000 | 2 | 20 | 374 | 381 | 38.5 | 0.0 |
| Average | .476 | 2.3 | 20.6 | 368.8 | 323.0 | 38.6 | 4.6 | ||||||||
| Total | 10-11 | .476 | 49 | 433 | 7,745 | 6,784 | 38.6 | 55.6 |
More 49ers Stats
Team Rankings
PPG
22.9
13th
OPP PPG
25.6
29th
RUSH YDS/G
127.2
12th
PASS YDS/G
260.2
4th
Cardinals 
NFL 2024 Leaders
NFL 2024 Rankings
NFL Fantasy 2024
NFL 2024 Betting
NFL 2024 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
