niners regular season record vs afc south opponets

The San Francisco 49ers have a record of 11-12 against the AFC South all-time.

TEAMDATERECTMOPPRESULTW%TD1DWNOFFOPP OFF3DWN%4DWN%
149ers
49ers
10/9/2005
0-1
SF SF
vs
IND IND
L
3-28
.000
0
12
177
365
21.4
100.0
249ers
49ers
11/27/2005
0-1
SF SF
@
TEN TEN
L
22-33
.000
3
15
261
461
20.0
100.0
349ers
49ers
12/18/2005
0-1
SF SF
@
JAX JAX
L
9-10
.000
0
11
217
336
7.7
0.0
449ers
49ers
1/1/2006
1-0
SF SF
vs
HOU HOU
W
20-17
1.000
2
19
324
284
36.8
549ers
49ers
10/25/2009
0-1
SF SF
@
HOU HOU
L
21-24
.000
3
17
297
336
36.4
0.0
649ers
49ers
11/1/2009
0-1
SF SF
@
IND IND
L
14-18
.000
2
16
295
410
20.0
749ers
49ers
11/8/2009
0-1
SF SF
vs
TEN TEN
L
27-34
.000
3
25
358
315
30.8
100.0
849ers
49ers
11/29/2009
1-0
SF SF
vs
JAX JAX
W
20-3
1.000
2
15
284
357
50.0
100.0
949ers
49ers
9/22/2013
0-1
SF SF
vs
IND IND
L
7-27
.000
1
14
254
336
25.0
100.0
1049ers
49ers
10/6/2013
1-0
SF SF
vs
HOU HOU
W
34-3
1.000
4
17
284
313
36.4
0.0
1149ers
49ers
10/20/2013
1-0
SF SF
@
TEN TEN
W
31-17
1.000
4
19
349
368
50.0
1249ers
49ers
10/27/2013
1-0
SF SF
@
JAX JAX
W
42-10
1.000
6
25
398
318
66.7
100.0
1349ers
49ers
10/8/2017
0-1
SF SF
@
IND IND
L
23-26
.000
2
23
402
447
28.6
100.0
1449ers
49ers
12/10/2017
1-0
SF SF
@
HOU HOU
W
26-16
1.000
2
20
416
311
18.2
1549ers
49ers
12/17/2017
1-0
SF SF
vs
TEN TEN
W
25-23
1.000
1
23
414
328
50.0
1649ers
49ers
12/24/2017
1-0
SF SF
vs
JAX JAX
W
44-33
1.000
6
26
369
472
66.7
1749ers
49ers
10/24/2021
0-1
SF SF
vs
IND IND
L
18-30
.000
2
13
280
295
9.1
1849ers
49ers
11/21/2021
1-0
SF SF
@
JAX JAX
W
30-10
1.000
3
25
333
200
50.0
100.0
1949ers
49ers
12/23/2021
0-1
SF SF
@
TEN TEN
L
17-20
.000
2
22
389
278
37.5
50.0
2049ers
49ers
1/2/2022
1-0
SF SF
vs
HOU HOU
W
23-7
1.000
2
19
416
222
38.5
0.0
2149ers
49ers
11/12/2023
1-0
SF SF
@
JAX JAX
W
34-3
1.000
4
20
437
221
33.3
50.0
2249ers
49ers
9/28/2025
0-1
SF SF
vs
JAX JAX
L
21-26
.000
2
22
389
325
61.5
0.0
2349ers
49ers
10/26/2025
0-1
SF SF
@
HOU HOU
L
15-26
.000
2
12
223
475
33.3
0.0
Average.4782.518.7329.0338.036.43.8
Total11-12.478584307,5667,77336.461.5

More 49ers Stats

Team Rankings

PPG

23.6

14th

OPP PPG

20.7

8th

RUSH YDS/G

98.5

26th

PASS YDS/G

253.7

8th

2025 Division Standings
TEAMWLTPCT
Rams Rams
9
3
0
.750
Seahawks Seahawks
9
3
0
.750
49ers 49ers
9
4
0
.692
Cardinals Cardinals
3
9
0
.250
Schedule
DATEMATCHUPTIME (ET)
Sun
12/14
TEN TEN
@
SF SF
4:25 PM
Mon
12/22
SF SF
@
IND IND
8:15 PM
Sun
12/28
CHI CHI
@
SF SF
8:20 PM
Sun
1/4
SEA SEA
@
SF SF
1:00 PM
Last Game
SF 49ers

9 - 4

26

Final

8

CLE Browns

3 - 9

Sun 30 Nov 2025

NFL 2025 Leaders

NFL 2025 Rankings

NFL Fantasy 2025

NFL 2025 Betting

NFL 2025 Division Standings

AFC EastWLTPCT
Patriots Patriots
11
2
0
.846
Bills Bills
8
4
0
.667
AFC NorthWLTPCT
Ravens Ravens
6
6
0
.500
Steelers Steelers
6
6
0
.500
AFC SouthWLTPCT
Jaguars Jaguars
8
4
0
.667
Colts Colts
8
4
0
.667
AFC WestWLTPCT
Broncos Broncos
10
2
0
.833
Chargers Chargers
8
4
0
.667
NFC EastWLTPCT
Eagles Eagles
8
4
0
.667
Cowboys Cowboys
6
6
1
.500
NFC NorthWLTPCT
Bears Bears
9
3
0
.750
Packers Packers
8
3
1
.708
NFC SouthWLTPCT
Buccaneers Buccaneers
7
5
0
.583
Panthers Panthers
7
6
0
.538
NFC WestWLTPCT
Rams Rams
9
3
0
.750
Seahawks Seahawks
9
3
0
.750

NFL 2025 Scores & Schedule

Scores

DATEMATCHUPSCORE
Wed
9/3
DAL DAL
@
PHI PHI
20-24
Thu
9/4
KC KC
@
LAC LAC
21-27
Sat
9/6
PIT PIT
@
NYJ NYJ
34-32
Sat
9/6
TB TB
@
ATL ATL
23-20
Sat
9/6
LV LV
@
NE NE
20-13

Schedule

DATEMATCHUPTIME (ET)
Sun
12/7
PIT PIT
@
BAL BAL
1:00 PM
Sun
12/7
SEA SEA
@
ATL ATL
1:00 PM
Sun
12/7
TEN TEN
@
CLE CLE
1:00 PM
Sun
12/7
IND IND
@
JAX JAX
1:00 PM
Sun
12/7
WAS WAS
@
MIN MIN
1:00 PM