The San Francisco 49ers are 53-58 against the AFC in the regular-season and playoffs on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/15/1970 | 1-0 |  SF | @ |  HOU | W 30-20 | 1.000 | 4 | 17 | 376 | 268 | ||
| 2 | | 49ers | 12/20/1970 | 1-0 | SF | @ |  OAK | W 38-7 | 1.000 | 5 | 16 | 296 | 358 | ||
| 3 | | 49ers | 11/28/1971 | 1-0 | SF | @ |  NYJ | W 24-21 | 1.000 | 3 | 20 | 351 | 393 | ||
| 4 | | 49ers | 9/24/1972 | 0-1 | SF | @ |  BUF | L 20-27 | .000 | 2 | 10 | 202 | 233 | ||
| 5 | | 49ers | 9/16/1973 | 0-1 | SF | @ |  MIA | L 13-21 | .000 | 1 | 16 | 252 | 279 | ||
| 6 | | 49ers | 9/23/1973 | 1-0 | SF | @ |  DEN | W 36-34 | 1.000 | 3 | 16 | 347 | 355 | ||
| 7 | | 49ers | 12/1/1974 | 0-1 | SF | @ |  CLE | L 0-7 | .000 | 0 | 14 | 192 | 183 | ||
| 8 | | 49ers | 10/5/1975 | 1-0 | SF | @ |  KC | W 20-3 | 1.000 | 2 | 15 | 215 | 212 | ||
| 9 | | 49ers | 10/26/1975 | 0-1 | SF | @ |  NE | L 16-24 | .000 | 2 | 14 | 243 | 306 | ||
| 10 | | 49ers | 12/5/1976 | 0-1 | SF | @ |  SD | L 7-13 | .000 | 1 | 18 | 281 | 267 | ||
| 11 | | 49ers | 9/19/1977 | 0-1 | SF | @ |  PIT | L 0-27 | .000 | 0 | 8 | 101 | 308 | ||
| 12 | | 49ers | 9/3/1978 | 0-1 | SF | @ | CLE | L 7-24 | .000 | 1 | 18 | 295 | 393 | ||
| 13 | | 49ers | 9/17/1978 | 0-1 | SF | @ | HOU | L 19-20 | .000 | 2 | 18 | 382 | 332 | ||
| 14 | | 49ers | 9/30/1979 | 0-1 | SF | @ | SD | L 9-31 | .000 | 1 | 14 | 242 | 317 | ||
| 15 | | 49ers | 11/4/1979 | 0-1 | SF | @ | OAK | L 10-23 | .000 | 1 | 19 | 363 | 309 | ||
| 16 | | 49ers | 9/21/1980 | 1-0 | SF | @ | NYJ | W 37-27 | 1.000 | 5 | 24 | 376 | 460 | ||
| 17 | | 49ers | 11/16/1980 | 0-1 | SF | @ | MIA | L 13-17 | .000 | 2 | 20 | 289 | 378 | ||
| 18 | | 49ers | 11/1/1981 | 1-0 | SF | @ | PIT | W 17-14 | 1.000 | 2 | 25 | 330 | 269 | ||
| 19 | | 49ers | 12/6/1981 | 1-0 | SF | @ |  CIN | W 21-3 | 1.000 | 3 | 24 | 325 | 345 | ||
| 20 | | 49ers | 1/24/1982 | 1-0 | SF | @ | CIN | W 26-21 | 1.000 | 2 | 20 | 275 | 356 | ||
| 21 | | 49ers | 9/19/1982 | 0-1 | SF | @ | DEN | L 21-24 | .000 | 3 | 20 | 413 | 283 | ||
| 22 | | 49ers | 12/26/1982 | 1-0 | SF | @ | KC | W 26-13 | 1.000 | 2 | 23 | 370 | 275 | ||
| 23 | | 49ers | 10/2/1983 | 1-0 | SF | @ | NE | W 33-13 | 1.000 | 3 | 29 | 426 | 295 | ||
| 24 | | 49ers | 12/11/1983 | 1-0 | SF | @ | BUF | W 23-10 | 1.000 | 2 | 19 | 310 | 303 | ||
| 25 | | 49ers | 10/21/1984 | 1-0 | SF | @ | HOU | W 34-21 | 1.000 | 4 | 25 | 517 | 432 | ||
| Average | .477 | 2.5 | 19.4 | 339.9 | 326.6 | ||||||||||
| Total | 53-58 | .477 | 272 | 2,157 | 37,731 | 36,249 | |||||||||
More 49ers Stats
Team Rankings
PPG
22.9
13th
OPP PPG
25.6
29th
RUSH YDS/G
127.2
12th
PASS YDS/G
260.2
4th
Cardinals 
NFL 2024 Leaders
NFL 2024 Rankings
NFL Fantasy 2024
NFL 2024 Betting
NFL 2024 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 14 | 3 | 0 | .824 |
 Commanders | 12 | 5 | 0 | .706 |
| NFC North | W | L | T | PCT |
 Lions | 15 | 2 | 0 | .882 |
 Vikings | 14 | 3 | 0 | .824 |
| NFC South | W | L | T | PCT |
 Buccaneers | 10 | 7 | 0 | .588 |
 Falcons | 8 | 9 | 0 | .471 |
| NFC West | W | L | T | PCT |
 Rams | 10 | 7 | 0 | .588 |
 Seahawks | 10 | 7 | 0 | .588 |
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