4 players are tied for the most interceptions in a Week-4 game, with 4 interceptions. The first three are Deltha O'Neal on October 7, 2001, Deron Cherry on September 29, 1985 and Willie Buchanon on September 24, 1978.
| NAME | INT | DATE | TM | OPP | TKL | AST | COMB | SCK | SCKY | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. O'Neal | 4 | 10/7/2001 |  DEN | vs |  KC | 3 | 0 | 3 | 0.0 | 0 | 69 | 0 | 0 | 0 | 0 |
| 2 | | D. Cherry | 4 | 9/29/1985 | KC | vs |  SEA | 0.0 | 24 | 0 | 0 | ||||||
| 3 | | W. Buchanon | 4 | 9/24/1978 |  GB | @ |  SD | 77 | 1 | 0 | |||||||
| 4 | | B. Hunt | 4 | 10/4/1964 | KC | vs |  HOU | 108 | 1 | 0 | |||||||
| 5 | | A. Talib | 3 | 10/4/2009 |  TB | @ |  WAS | 4 | 0 | 4 | 0.0 | 0 | 61 | 0 | 0 | 0 | 0 |
| 6 | | G. Wesley | 3 | 9/29/2002 | KC | vs |  MIA | 3 | 0 | 3 | 0.0 | 0 | 71 | 0 | 0 | 0 | 0 |
| 7 |  | R. Woodson | 3 | 9/29/2002 |  OAK | vs | TEN | 3 | 1 | 4 | 0.0 | 0 | 100 | 1 | 0 | 0 | 0 |
| 8 | | K. Schulz | 3 | 9/24/2000 |  DET | @ |  CHI | 0.0 | 8 | 0 | 0 | ||||||
| 9 | | D. Williams | 3 | 9/21/1997 | SEA | vs | SD | 0.0 | 48 | 0 | 0 | ||||||
| 10 | | T. Scott | 3 | 9/27/1992 |  MIN | @ |  CIN | 0.0 | 15 | 0 | 0 | ||||||
| 11 | | D. Fulcher | 3 | 10/1/1989 | CIN | @ | KC | 0.0 | 38 | 0 | 0 | ||||||
| 12 | | S. Foley | 3 | 9/27/1981 | DEN | vs | SD | 42 | 0 | 0 | |||||||
| 13 | | M. Wagner | 3 | 9/28/1980 |  PIT | vs | CHI | 0 | 0 | 0 | |||||||
| 14 | | G. Atkinson | 3 | 10/6/1974 | OAK | @ |  CLE | 13 | 0 | 0 | |||||||
| 15 | | B. Byrd | 3 | 10/5/1969 |  BUF | @ | HOU | 60 | 0 | 0 | |||||||
| 16 | | S. Duncan | 3 | 9/25/1966 | SD | @ | OAK | 32 | 0 | 0 | |||||||
| 17 | | D. Paulson | 3 | 9/28/1963 |  NYJ | vs | OAK | 90 | 0 | 0 | |||||||
| 18 | | D. Lynch | 3 | 10/8/1961 |  NYG | @ |  STL | 12 | 0 | 0 | |||||||
| 19 | | J. Sample | 3 | 10/8/1961 | PIT | @ |  PHI | 56 | 0 | 0 | |||||||
| 20 | | D. Bland | 2 | 10/1/2023 |  DAL | vs |  NE | 3 | 1 | 4 | 0.0 | 0 | 64 | 1 | 0 | 0 | 0 |
| 21 | | J. Jacobs | 2 | 9/28/2023 | DET | @ | GB | 5 | 0 | 5 | 0.0 | 0 | 34 | 0 | 0 | 0 | 0 |
| 22 | | J. Poyer | 2 | 10/2/2022 | BUF | @ |  BAL | 4 | 2 | 6 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 23 | | L. Joyner | 2 | 10/2/2022 |  NYJ | @ | PIT | 1 | 5 | 6 | 0.0 | 0 | 4 | 0 | 0 | 0 | 0 |
| 24 | | V. Bell | 2 | 9/29/2022 | CIN | vs | MIA | 4 | 0 | 4 | 0.0 | 0 | 46 | 0 | 0 | 0 | 0 |
| 25 |  | T. Diggs | 2 | 10/3/2021 | DAL | vs |  CAR | 4 | 0 | 4 | 0.0 | 0 | 23 | 0 | 0 | 0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.
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