Lamar Jackson has the most carries by a quarterback in a game, with 26 rush attempts against the Bengals on November 18, 2018.

which qb has the most rushing attempts in a game in nfl history
Interpreted as:
Which qb has the most rushing attempts in a regular-season game in NFL history?
Results may be incomplete. StatMuse has complete game-level data for rush attempts going back to the 1960 season.

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