Lamar Jackson has the most carries by a quarterback in a game, with 26 rush attempts against the Bengals on November 18, 2018.

which qb has the most rushing attempts in a game in nfl history
Interpreted as:
Which qb has the most rushing attempts in a regular-season game in NFL history?
11/18/2018Jackson11/27/2011Tebow12/30/2018Jackson10/15/1961Kilmer10/13/2019Jackson11/4/1973Douglass10/8/1961Kilmer11/3/1935Shepherd12/13/2020Hurts12/16/2018Jackson10/16/1960Dorow11/1/1953Layne12/22/2019Jackson12/2/2018Jackson10/12/2014Newton12/9/1951Rote11/19/1944Davis11/1/2020Jackson9/20/2020Jackson12/1/2019Jackson11/3/2019Jackson9/15/2019Jackson26222020191919191818181817171717171616161616
Results may be incomplete. StatMuse has complete game-level data for rush attempts going back to the 1960 season.

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