Lito Sheppard has defended the most passes in a game, with 7 passes defended against the Cowboys on October 8, 2006.

who has the most pass defended in a game
Interpreted as:
Who has the most pass defended in a regular-season game?
10/8/2006Sheppard12/24/2017Fuller10/2/2016Johnson11/29/2015Amerson12/29/2013McBride11/10/2013Webb10/29/2012Brown12/5/2010Grimes11/17/2008McGee10/7/2007Brown11/12/2006Rogers9/14/2003McKenzie11/17/2002Bailey9/15/2002Barber9/8/2002Glenn10/7/2001O'Neal11/22/2020Jenkins11/1/2020Rowe12/22/2019Desir11/24/2019Davis11/24/2019Dean11/10/2019Haden10/10/2019Gilmore76666666666666665555555
NAMEDATETMOPPPDEFTKLASTCOMBSCKSCKYINTINT YDSINT TDFFFRFR TD
Lito SheppardLito Sheppard10/8/2006PHIPHIvs. DAL
vs.
77180.0021021000
Kyle FullerKyle Fuller12/24/2017CHICHIvs. CLE
vs.
61010.00100000
Trumaine JohnsonTrumaine Johnson10/2/2016LALA@ ARI
@
65050.00100000
David AmersonDavid Amerson11/29/2015OAKOAK@ TEN
@
62020.00120000
Trumaine McBrideTrumaine McBride12/29/2013NYGNYGvs. WAS
vs.
60000.002170000
Lardarius WebbLardarius Webb11/10/2013BALBALvs. CIN
vs.
62350.00100000
Tarell BrownTarell Brown10/29/2012SFSF@ ARI
@
61010.00000000
Brent GrimesBrent Grimes12/5/2010ATLATL@ TB
@
66170.001330000
Terrence McGeeTerrence McGee11/17/2008BUFBUFvs. CLE
vs.
66060.00000000
Fakhir BrownFakhir Brown10/7/2007STLSTLvs. ARI
vs.
69090.002120000
Carlos RogersCarlos Rogers11/12/2006WASWAS@ PHI
@
64150.00000000
Mike McKenzieMike McKenzie9/14/2003GBGBvs. DET
vs.
63030.00100000
Champ BaileyChamp Bailey11/17/2002WASWAS@ NYG
@
67070.00000010
Ronde BarberRonde Barber9/15/2002TBTB@ BAL
@
63250.00000000
Aaron GlennAaron Glenn9/8/2002HOUHOUvs. DAL
vs.
65050.00100000
Deltha O'NealDeltha O'Neal10/7/2001DENDENvs. KC
vs.
63030.004690000
Janoris JenkinsJanoris Jenkins11/22/2020NONOvs. ATL
vs.
54150.00130000
Eric RoweEric Rowe11/1/2020MIAMIAvs. LAR
vs.
55270.00140000
Pierre DesirPierre Desir12/22/2019INDINDvs. CAR
vs.
54150.00200000
Carlton DavisCarlton Davis11/24/2019TBTB@ ATL
@
55050.00100000
Jamel DeanJamel Dean11/24/2019TBTB@ ATL
@
52020.00000000
Joe HadenJoe Haden11/10/2019PITPITvs. LAR
vs.
56170.00100100
Stephon GilmoreStephon Gilmore10/10/2019NENEvs. NYG
vs.
52130.00100000
Jaire AlexanderJaire Alexander10/28/2018GBGB@ LAR
@
57070.00000000
Kevin PetersonKevin Peterson12/31/2017LARLARvs. SF
vs.
54480.002420010
StatMuse has game-level data for passes defended going back to the 2001 season.

See Trending NFL Searches