The San Francisco 49ers have a 6-3 record against the spread as favorites against the NFC South since January 26, 2020.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/19/2021 | 1-0 |  SF | -408 | vs |  ATL | +311 | W 31-13 | -9 | +9 (Y) | 47.5 | -3.5 (U) | 4 | 23 | 397 | 275 | 54.5 | |
| 2 | | 49ers | 10/9/2022 | 1-0 | SF | -261 | @ |  CAR | +211 | W 37-15 | -6 | +16 (Y) | 39.5 | +12.5 (O) | 5 | 22 | 397 | 308 | 58.3 | |
| 3 | | 49ers | 10/16/2022 | 0-1 | SF | -192 | @ | ATL | +161 | L 14-28 | -3.5 | -17.5 (N) | 46 | -4 (U) | 2 | 21 | 346 | 289 | 37.5 | 0.0 |
| 4 | | 49ers | 11/27/2022 | 1-0 | SF | -426 | vs |  NO | +325 | W 13-0 | -8.5 | +4.5 (Y) | 43.5 | -30.5 (U) | 1 | 21 | 317 | 260 | 38.5 | 50.0 |
| 5 | | 49ers | 12/11/2022 | 1-0 | SF | -182 | vs |  TB | +152 | W 35-7 | -3.5 | +24.5 (Y) | 38.5 | +3.5 (O) | 5 | 24 | 404 | 322 | 44.4 | 50.0 |
| 6 | | 49ers | 11/19/2023 | 0-1 | SF | -831 | vs | TB | +567 | W 27-14 | -13.5 | -0.5 (N) | 41.5 | -0.5 (U) | 3 | 22 | 420 | 287 | 40.0 | 0.0 |
| 7 | | 49ers | 11/10/2024 | 0-1 | SF | -299 | @ | TB | +240 | W 23-20 | -6.5 | -3.5 (N) | 49 | -6 (U) | 2 | 24 | 413 | 215 | 45.5 | |
| 8 | | 49ers | 9/14/2025 | 1-0 | SF | -162 | @ | NO | +137 | W 26-21 | -3 | +2 (Y) | 40.5 | +6.5 (O) | 3 | 23 | 344 | 307 | 53.3 | |
| 9 | | 49ers | 10/19/2025 | 1-0 | SF | -106 | vs | ATL | -112 | W 20-10 | -1.5 | +8.5 (Y) | 46.5 | -16.5 (U) | 2 | 23 | 324 | 292 | 60.0 | |
| Average | 7.4 | 3.0 | 22.6 | 373.6 | 283.9 | 49.0 | 8.3 | |||||||||||||
| Total | 6-3 | 27 | 203 | 3,362 | 2,555 | 49.0 | 33.3 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
23.7
14th
OPP PPG
22.9
16th
RUSH YDS/G
94.8
28th
PASS YDS/G
267.0
3rd
Rams
Seahawks
Cardinals
CLE
TEN
IND
CHI
Patriots
Bills
Ravens
Steelers
Jaguars
Broncos
Chargers
Eagles
Cowboys
Packers
KC
NYJ
LV
DET
CIN
