The San Francisco 49ers have a point differential of 385 points in the regular-season and playoffs since May 4, 2020.
| TEAM | DATE | DIFF | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/13/2020 | -4 |  SF | vs |  ARI | L 20-24 | 2 | 18 | 366 | 404 | 18.2 | 0.0 |
| 2 | | 49ers | 9/20/2020 | 18 | SF | @ |  NYJ | W 31-13 | 4 | 17 | 359 | 277 | 53.8 | |
| 3 | | 49ers | 9/27/2020 | 27 | SF | @ |  NYG | W 36-9 | 4 | 29 | 420 | 231 | 66.7 | |
| 4 | | 49ers | 10/4/2020 | -5 | SF | vs |  PHI | L 20-25 | 3 | 25 | 417 | 267 | 45.5 | 0.0 |
| 5 | | 49ers | 10/11/2020 | -26 | SF | vs |  MIA | L 17-43 | 2 | 19 | 259 | 436 | 20.0 | 0.0 |
| 6 | | 49ers | 10/18/2020 | 8 | SF | vs |  LAR | W 24-16 | 3 | 24 | 390 | 311 | 38.5 | 100.0 |
| 7 | | 49ers | 10/25/2020 | 27 | SF | @ |  NE | W 33-6 | 4 | 26 | 467 | 241 | 55.6 | |
| 8 | | 49ers | 11/1/2020 | -10 | SF | @ |  SEA | L 27-37 | 4 | 24 | 351 | 350 | 46.2 | 100.0 |
| 9 | | 49ers | 11/5/2020 | -17 | SF | vs |  GB | L 17-34 | 2 | 17 | 337 | 405 | 30.0 | 0.0 |
| 10 | | 49ers | 11/15/2020 | -14 | SF | @ |  NO | L 13-27 | 1 | 21 | 281 | 237 | 43.8 | 0.0 |
| 11 | | 49ers | 11/29/2020 | 3 | SF | @ | LAR | W 23-20 | 2 | 18 | 345 | 308 | 21.4 | 100.0 |
| 12 | | 49ers | 12/7/2020 | -10 | SF | vs |  BUF | L 24-34 | 3 | 24 | 402 | 449 | 54.5 | 0.0 |
| 13 | | 49ers | 12/13/2020 | -8 | SF | vs |  WAS | L 15-23 | 2 | 21 | 344 | 193 | 26.7 | 0.0 |
| 14 | | 49ers | 12/20/2020 | -8 | SF | @ |  DAL | L 33-41 | 4 | 28 | 458 | 291 | 40.0 | 100.0 |
| 15 | | 49ers | 12/26/2020 | 8 | SF | @ | ARI | W 20-12 | 3 | 22 | 398 | 350 | 22.2 | |
| 16 | | 49ers | 1/3/2021 | -3 | SF | vs | SEA | L 23-26 | 2 | 17 | 328 | 280 | 40.0 | 100.0 |
| 17 | | 49ers | 9/12/2021 | 8 | SF | @ |  DET | W 41-33 | 5 | 21 | 442 | 430 | 33.3 | |
| 18 | | 49ers | 9/19/2021 | 6 | SF | @ | PHI | W 17-11 | 2 | 23 | 306 | 328 | 42.9 | 100.0 |
| 19 | | 49ers | 9/26/2021 | -2 | SF | vs | GB | L 28-30 | 4 | 26 | 298 | 353 | 63.6 | |
| 20 | | 49ers | 10/3/2021 | -7 | SF | vs | SEA | L 21-28 | 3 | 23 | 457 | 234 | 14.3 | 75.0 |
| 21 | | 49ers | 10/10/2021 | -7 | SF | @ | ARI | L 10-17 | 1 | 19 | 338 | 304 | 27.3 | 20.0 |
| 22 | | 49ers | 10/24/2021 | -12 | SF | vs |  IND | L 18-30 | 2 | 13 | 280 | 295 | 9.1 | |
| 23 | | 49ers | 10/31/2021 | 11 | SF | @ |  CHI | W 33-22 | 3 | 21 | 467 | 324 | 40.0 | 100.0 |
| 24 | | 49ers | 11/7/2021 | -14 | SF | vs | ARI | L 17-31 | 2 | 22 | 337 | 437 | 40.0 | |
| 25 | | 49ers | 11/15/2021 | 21 | SF | vs | LAR | W 31-10 | 4 | 20 | 335 | 278 | 57.1 | 50.0 |
| Average | 3.9 | 2.9 | 21.2 | 372.9 | 312.5 | 43.1 | 0.8 | |||||||
| Total | 385 | 281 | 2,078 | 36,541 | 30,627 | 43.1 | 47.9 | |||||||
More 49ers Stats
Team Rankings
PPG
21.2
22nd
OPP PPG
19.6
6th
RUSH YDS/G
85.2
28th
PASS YDS/G
298.2
2nd
HOU 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
| Lions | 4 | 1 | 0 | .800 |
| Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
| Seahawks | 3 | 2 | 0 | .600 |
Steelers 
Bengals 
Jaguars 
Chargers 
Broncos 
KC 
NYJ 
LV 
BAL 
CLE 
