The San Francisco 49ers are 5-10 against the AFC West in the regular-season and playoffs since December 9, 2012.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/5/2014 | 1-0 | vs | W 22-17 | 1.000 | 1 | 22 | 357 | 265 | 37.5 | 100.0 | ||
| 2 | | 49ers | 10/19/2014 | 0-1 | @ | L 17-42 | .000 | 2 | 22 | 310 | 419 | 23.1 | 50.0 | ||
| 3 | | 49ers | 12/7/2014 | 0-1 | @ | L 13-24 | .000 | 1 | 18 | 248 | 330 | 27.3 | 100.0 | ||
| 4 | | 49ers | 12/20/2014 | 0-1 | vs | L 35-38 | .000 | 5 | 21 | 447 | 446 | 45.5 | 0.0 | ||
| 5 | | 49ers | 9/23/2018 | 0-1 | @ | L 27-38 | .000 | 3 | 26 | 406 | 384 | 22.2 | 100.0 | ||
| 6 | | 49ers | 9/30/2018 | 0-1 | @ | L 27-29 | .000 | 3 | 22 | 364 | 368 | 41.7 | |||
| 7 | | 49ers | 11/1/2018 | 1-0 | vs | W 34-3 | 1.000 | 4 | 18 | 405 | 242 | 41.7 | |||
| 8 | | 49ers | 12/9/2018 | 1-0 | vs | W 20-14 | 1.000 | 2 | 24 | 389 | 274 | 30.8 | 0.0 | ||
| 9 | | 49ers | 2/2/2020 | 0-1 | @ | L 20-31 | .000 | 2 | 21 | 351 | 397 | 37.5 | 0.0 | ||
| 10 | | 49ers | 9/25/2022 | 0-1 | @ | L 10-11 | .000 | 1 | 13 | 267 | 261 | 10.0 | |||
| 11 | | 49ers | 10/23/2022 | 0-1 | vs | L 23-44 | .000 | 2 | 25 | 444 | 529 | 57.1 | |||
| 12 | | 49ers | 11/13/2022 | 1-0 | vs | W 22-16 | 1.000 | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| 13 | | 49ers | 1/1/2023 | 1-0 | @ | W 37-34 | 1.000 | 4 | 27 | 454 | 500 | 50.0 | |||
| 14 | | 49ers | 2/11/2024 | 0-1 | @ | L 22-25 | .000 | 2 | 23 | 382 | 455 | 25.0 | 100.0 | ||
| 15 | | 49ers | 10/20/2024 | 0-1 | vs | L 18-28 | .000 | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| Average | .333 | 2.4 | 21.5 | 368.1 | 362.5 | 35.6 | 6.7 | ||||||||
| Total | 5-10 | .333 | 36 | 323 | 5,521 | 5,437 | 35.6 | 66.7 |
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
