Calais Campbell had his most sacks in a game against the Texans on September 10, 2017, with 4 sacks.
Interpreted as:
Calais Campbell all-time defensive sack in a regular-season game ranking| NAME | SCK | DATE | TM | OPP | TKL | AST | COMB | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | C. Campbell | 4.0 | 9/10/2017 |  JAX | @ |  HOU | 4 | 2 | 6 | 17.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | | C. Campbell | 3.0 | 10/18/2020 |  BAL | @ |  PHI | 4 | 1 | 5 | 23 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | | C. Campbell | 3.0 | 9/19/2019 | JAX | vs |  TEN | 6 | 0 | 6 | 22 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | | C. Campbell | 3.0 | 11/23/2014 |  ARI | @ |  SEA | 4 | 2 | 6 | 19 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 | | C. Campbell | 2.5 | 12/27/2015 | ARI | vs |  GB | 5 | 1 | 6 | 17 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | | C. Campbell | 2.5 | 9/25/2011 | ARI | @ | SEA | 5 | 5 | 10 | 16.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 7 | | C. Campbell | 2.0 | 9/14/2025 | ARI | vs |  CAR | 4 | 1 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | | C. Campbell | 2.0 | 9/23/2018 | JAX | vs | TEN | 5 | 0 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | | C. Campbell | 2.0 | 12/17/2017 | JAX | vs | HOU | 5 | 0 | 5 | 11 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | | C. Campbell | 2.0 | 10/22/2017 | JAX | @ |  IND | 2 | 2 | 4 | 16.5 | 0 | 0 | 0 | 1 | 0 | 0 |
| 11 | | C. Campbell | 2.0 | 10/15/2017 | JAX | vs |  LAR | 4 | 1 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 |
| 12 | | C. Campbell | 2.0 | 12/18/2016 | ARI | vs |  NO | 4 | 0 | 4 | 24 | 0 | 0 | 0 | 0 | 1 | 1 |
| 13 | | C. Campbell | 2.0 | 10/6/2016 | ARI | @ |  SF | 3 | 1 | 4 | 5 | 1 | 1 | 0 | 0 | 0 | 0 |
| 14 | | C. Campbell | 2.0 | 11/9/2014 | ARI | vs |  STL | 5 | 1 | 6 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
| 15 | | C. Campbell | 2.0 | 12/22/2013 | ARI | @ | SEA | 3 | 1 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
| 16 | | C. Campbell | 2.0 | 10/6/2013 | ARI | vs | CAR | 4 | 0 | 4 | 13 | 0 | 0 | 0 | 1 | 0 | 0 |
| 17 | | C. Campbell | 2.0 | 9/16/2012 | ARI | @ |  NE | 7 | 3 | 10 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | | C. Campbell | 2.0 | 11/6/2011 | ARI | vs | STL | 6 | 0 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 0 |
| 19 | | C. Campbell | 1.5 | 12/24/2023 |  ATL | vs | IND | 1 | 2 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 |
| 20 | | C. Campbell | 1.5 | 10/27/2019 | JAX | vs |  NYJ | 1 | 2 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| 21 | | C. Campbell | 1.5 | 12/30/2018 | JAX | @ | HOU | 5 | 2 | 7 | 3.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 22 | | C. Campbell | 1.5 | 1/1/2017 | ARI | @ | LA | 1 | 2 | 3 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
| 23 | | C. Campbell | 1.5 | 10/18/2009 | ARI | @ | SEA | 2 | 1 | 3 | 12.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 24 | | C. Campbell | 1.0 | 9/25/2025 | ARI | vs | SEA | 2 | 1 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| 25 | | C. Campbell | 1.0 | 1/5/2025 |  MIA | @ |  NYJ | 2 | 1 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
StatMuse has game-level data for sacks going back to the 1982 season.
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