The Buffalo Bills have a point differential of 40 points in the regular season and playoffs against the Jaguars all-time.
| TEAM | DATE | DIFF | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 12/28/1996 | -3 | vs | L 27-30 | 3 | 19 | 308 | 409 | 33.3 | 0.0 | ||
| 2 | | Bills | 12/14/1997 | -6 | vs | L 14-20 | 1 | 24 | 335 | 388 | 52.9 | 66.7 | ||
| 3 | | Bills | 10/18/1998 | 1 | vs | W 17-16 | 2 | 22 | 337 | 238 | 53.3 | 100.0 | ||
| 4 | | Bills | 10/18/2001 | 3 | @ | W 13-10 | 1 | 19 | 317 | 247 | 42.9 | |||
| 5 | | Bills | 9/14/2003 | 21 | @ | W 38-17 | 5 | 20 | 371 | 287 | 57.1 | 50.0 | ||
| 6 | | Bills | 9/12/2004 | -3 | vs | L 10-13 | 1 | 16 | 242 | 225 | 50.0 | |||
| 7 | | Bills | 11/26/2006 | 3 | vs | W 27-24 | 3 | 13 | 241 | 323 | 30.0 | |||
| 8 | | Bills | 11/25/2007 | -22 | @ | L 14-36 | 2 | 20 | 297 | 416 | 56.3 | 50.0 | ||
| 9 | | Bills | 9/14/2008 | 4 | @ | W 20-16 | 2 | 18 | 285 | 243 | 54.5 | |||
| 10 | | Bills | 11/22/2009 | -3 | @ | L 15-18 | 1 | 14 | 343 | 310 | 27.3 | 0.0 | ||
| 11 | | Bills | 10/10/2010 | -10 | vs | L 26-36 | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 12 | | Bills | 12/2/2012 | 16 | vs | W 34-18 | 4 | 20 | 344 | 236 | 41.7 | 0.0 | ||
| 13 | | Bills | 12/15/2013 | 7 | @ | W 27-20 | 3 | 25 | 366 | 354 | 38.5 | |||
| 14 | | Bills | 10/25/2015 | -3 | @ | L 31-34 | 3 | 26 | 375 | 295 | 25.0 | 0.0 | ||
| 15 | | Bills | 11/27/2016 | 7 | vs | W 28-21 | 4 | 15 | 304 | 301 | 41.7 | 100.0 | ||
| 16 | | Bills | 1/7/2018 | -7 | @ | L 3-10 | 0 | 20 | 263 | 230 | 38.9 | 100.0 | ||
| 17 | | Bills | 11/25/2018 | 3 | vs | W 24-21 | 3 | 18 | 327 | 333 | 20.0 | |||
| 18 | | Bills | 11/7/2021 | -3 | @ | L 6-9 | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 19 | | Bills | 10/8/2023 | -5 | vs | L 20-25 | 3 | 18 | 388 | 474 | 41.7 | |||
| 20 | | Bills | 9/23/2024 | 37 | vs | W 47-10 | 6 | 25 | 388 | 239 | 54.5 | 100.0 | ||
| 21 | | Bills | 1/11/2026 | 3 | @ | W 27-24 | 3 | 20 | 340 | 359 | 50.0 | 100.0 | ||
| Average | 1.9 | 2.5 | 19.3 | 322.8 | 309.8 | 42.6 | 0.0 | |||||||
| Total | 40 | 53 | 406 | 6,778 | 6,506 | 42.6 | 52.4 |
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC North | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC South | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 |
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