The Indianapolis Colts have a record of 4-1 against the spread against the 49ers on the road all-time.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Colts | 10/5/1986 | 0-1 | @ | L 14-35 | +17 | -4 (N) | 39.5 | +9.5 (O) | 2 | 17 | 323 | 358 | ||||||
| 2 | | Colts | 10/18/1998 | 1-0 | @ | L 31-34 | +17.5 | +14.5 (Y) | 44.5 | +20.5 (O) | 4 | 15 | 336 | 448 | 36.4 | |||||
| 3 | | Colts | 10/9/2005 | 1-0 | @ | W 28-3 | -15 | +10 (Y) | 46.5 | -15.5 (U) | 4 | 22 | 365 | 177 | 60.0 | 100.0 | ||||
| 4 | | Colts | 9/22/2013 | 1-0 | +400 | @ | -500 | W 27-7 | +10 | +30 (Y) | 46 | -12 (U) | 3 | 23 | 336 | 254 | 41.7 | |||
| 5 | | Colts | 10/24/2021 | 1-0 | +147 | @ | -176 | W 30-18 | +3.5 | +15.5 (Y) | 41.5 | +6.5 (O) | 4 | 17 | 295 | 280 | 42.9 | 100.0 | ||
| Average | 16.0 | 3.4 | 18.8 | 331.0 | 303.4 | |||||||||||||||
| Total | 4-1 | 17 | 94 | 1,655 | 1,517 |
IND
SFStatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
Rams LT Alaric Jackson strikes Bills LB Bradley Chubb after OT game
Josh Allen racks up 331 yards and Bills outlast Rams with help from blocked FG for 37-34 win in OT
Vikings playing keen game of keep-away, with hefty possession time and NFL's top turnover rate
Lions needed clutch 4th-down conversions to spark their blowout of the Cardinals
Fernando Mendoza looked ready in garbage time, but Raiders' offense still belongs to Kirk Cousins
WR DJ Moore is out for Bills' Monday night showdown with Rams
More Colts Stats
Team Leaders 
PASS
1,021
Jones
RUSH
398
Taylor
REC
249
Downs
Team Rankings
PPG
24.8
11th
OPP PPG
27.6
27th
RUSH YDS/G
100.8
20th
PASS YDS/G
204.2
23rd
Jaguars
Texans
Titans
MIN
DAL
MIA
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Commanders
Packers
Lions
Bears
Panthers
Falcons
Buccaneers
Saints
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Bills
Patriots
Jets
Ravens
Browns
Steelers
Bengals
Chiefs
Broncos
Raiders
Chargers