The San Francisco 49ers had their highest point differential in a loss 22 times, with a -1-point differential.
Interpreted as:
largest point differential in a regular-season game 49ers lose all-time| TEAM | DIFF | L | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | -1 | 1 | 10/6/2024 |  SF | vs |  ARI | L 23-24 | 2 | 22 | 384 | 358 | 54.5 | 0.0 |
| 2 | | 49ers | -1 | 1 | 1/7/2024 | SF | vs |  LAR | L 20-21 | 3 | 20 | 300 | 258 | 50.0 | 100.0 |
| 3 | | 49ers | -1 | 1 | 9/25/2022 | SF | @ |  DEN | L 10-11 | 1 | 13 | 267 | 261 | 10.0 | |
| 4 | | 49ers | -1 | 1 | 11/10/2013 | SF | vs |  CAR | L 9-10 | 0 | 10 | 151 | 250 | 15.4 | |
| 5 | | 49ers | -1 | 1 | 12/18/2005 | SF | @ |  JAX | L 9-10 | 0 | 11 | 217 | 336 | 7.7 | 0.0 |
| 6 | | 49ers | -1 | 1 | 10/12/2003 | SF | @ |  SEA | L 19-20 | 2 | 19 | 261 | 333 | 41.7 | |
| 7 | | 49ers | -1 | 1 | 9/21/2003 | SF | vs |  CLE | L 12-13 | 0 | 15 | 265 | 251 | 33.3 | 0.0 |
| 8 | | 49ers | -1 | 1 | 12/24/1995 | SF | @ |  ATL | L 27-28 | 3 | 23 | 434 | 363 | 50.0 | 50.0 |
| 9 | | 49ers | -1 | 1 | 10/15/1995 | SF | @ |  IND | L 17-18 | 2 | 21 | 269 | 257 | 50.0 | 0.0 |
| 10 | | 49ers | -1 | 1 | 10/1/1989 | SF | vs |  RAM | L 12-13 | 0 | 22 | 367 | 287 | ||
| 11 | | 49ers | -1 | 1 | 11/6/1988 | SF | @ |  PHX | L 23-24 | 2 | 22 | 357 | 355 | ||
| 12 | | 49ers | -1 | 1 | 10/24/1988 | SF | @ |  CHI | L 9-10 | 1 | 12 | 213 | 237 | ||
| 13 | | 49ers | -1 | 1 | 11/11/1985 | SF | @ | DEN | L 16-17 | 1 | 16 | 341 | 336 | ||
| 14 | | 49ers | -1 | 1 | 1/2/1983 | SF | vs | RAM | L 20-21 | 3 | 18 | 324 | 374 | ||
| 15 | | 49ers | -1 | 1 | 10/26/1980 | SF | vs |  TB | L 23-24 | 2 | 15 | 305 | 263 | ||
| 16 | | 49ers | -1 | 1 | 10/28/1979 | SF | vs | CHI | L 27-28 | 3 | 28 | 455 | 352 | ||
| 17 | | 49ers | -1 | 1 | 9/17/1978 | SF | @ |  HOU | L 19-20 | 2 | 18 | 382 | 332 | ||
| 18 | | 49ers | -1 | 1 | 12/4/1977 | SF | @ |  MIN | L 27-28 | 3 | 19 | 243 | 309 | ||
| 19 | | 49ers | -1 | 1 | 10/4/1970 | SF | @ | ATL | L 20-21 | 2 | 18 | 326 | 356 | ||
| 20 | | 49ers | -1 | 1 | 11/20/1966 | SF | vs |  PHI | L 34-35 | 4 | 24 | 404 | 289 | ||
| 21 | | 49ers | -1 | 1 | 10/24/1965 | SF | vs | MIN | L 41-42 | 5 | 21 | 438 | 549 | ||
| 22 | | 49ers | -1 | 1 | 10/11/1959 | SF | @ |  GB | L 20-21 | 2 | 13 | 239 | 371 | ||
| 23 | | 49ers | -2 | 1 | 10/15/2023 | SF | @ | CLE | L 17-19 | 2 | 15 | 215 | 334 | 25.0 | |
| 24 | | 49ers | -2 | 1 | 9/26/2021 | SF | vs | GB | L 28-30 | 4 | 26 | 298 | 353 | 63.6 | |
| 25 | | 49ers | -2 | 1 | 9/30/2018 | SF | @ |  LAC | L 27-29 | 3 | 22 | 364 | 368 | 41.7 | |
More 49ers Stats
Team Rankings
PPG
19.7
23rd
OPP PPG
16.3
3rd
RUSH YDS/G
89.7
26th
PASS YDS/G
280.0
3rd
HOU 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
| Packers | 2 | 1 | 0 | .667 |
| Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 0 | 0 | 1.000 |
| Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
| Rams | 2 | 1 | 0 | .667 |
Bills 
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Bengals 
Steelers 
Raiders 
DAL 
KC 
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NO 
TEN 
DET 
