The Detroit Lions are 3-15 in the regular-season and playoffs against the 49ers since December 28, 1992.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Lions | 12/28/1992 | 0-1 |  DET | @ |  SF | L 6-24 | .000 | 0 | 15 | 227 | 361 | 42.9 | 100.0 |
| 2 | | Lions | 12/19/1993 | 0-1 | DET | vs | SF | L 17-55 | .000 | 2 | 16 | 288 | 565 | 45.5 | 50.0 |
| 3 | | Lions | 10/9/1994 | 0-1 | DET | vs | SF | L 21-27 | .000 | 3 | 21 | 340 | 233 | 44.4 | |
| 4 | | Lions | 9/25/1995 | 1-0 | DET | vs | SF | W 27-24 | 1.000 | 2 | 23 | 316 | 416 | 50.0 | 100.0 |
| 5 | | Lions | 12/23/1996 | 0-1 | DET | @ | SF | L 14-24 | .000 | 2 | 18 | 277 | 281 | 28.6 | 75.0 |
| 6 | | Lions | 12/14/1998 | 0-1 | DET | @ | SF | L 13-35 | .000 | 2 | 25 | 380 | 409 | 27.3 | 66.7 |
| 7 | | Lions | 11/4/2001 | 0-1 | DET | @ | SF | L 13-21 | .000 | 1 | 12 | 131 | 427 | 25.0 | 0.0 |
| 8 | | Lions | 10/5/2003 | 0-1 | DET | @ | SF | L 17-24 | .000 | 2 | 15 | 305 | 325 | 18.2 | 0.0 |
| 9 | | Lions | 11/12/2006 | 0-1 | DET | vs | SF | L 13-19 | .000 | 1 | 16 | 251 | 315 | 33.3 | 0.0 |
| 10 | | Lions | 9/21/2008 | 0-1 | DET | @ | SF | L 13-31 | .000 | 1 | 14 | 240 | 370 | 38.5 | 100.0 |
| 11 | | Lions | 12/27/2009 | 0-1 | DET | @ | SF | L 6-20 | .000 | 0 | 16 | 289 | 310 | 16.7 | 0.0 |
| 12 | | Lions | 10/16/2011 | 0-1 | DET | vs | SF | L 19-25 | .000 | 2 | 21 | 310 | 314 | 13.3 | 50.0 |
| 13 | | Lions | 9/16/2012 | 0-1 | DET | @ | SF | L 19-27 | .000 | 1 | 15 | 296 | 349 | 40.0 | 100.0 |
| 14 | | Lions | 12/27/2015 | 1-0 | DET | vs | SF | W 32-17 | 1.000 | 3 | 26 | 371 | 322 | 33.3 | 100.0 |
| 15 | | Lions | 9/16/2018 | 0-1 | DET | @ | SF | L 27-30 | .000 | 3 | 25 | 427 | 346 | 43.8 | 0.0 |
| 16 | | Lions | 9/12/2021 | 0-1 | DET | vs | SF | L 33-41 | .000 | 4 | 31 | 430 | 442 | 26.7 | 40.0 |
| 17 | | Lions | 1/28/2024 | 0-1 | DET | @ | SF | L 31-34 | .000 | 4 | 28 | 442 | 413 | 50.0 | 33.3 |
| 18 | | Lions | 12/30/2024 | 1-0 | DET | @ | SF | W 40-34 | 1.000 | 5 | 23 | 439 | 475 | 64.3 | 66.7 |
| Average | .167 | 2.1 | 20.0 | 319.9 | 370.7 | 35.8 | 3.1 | ||||||||
| Total | 3-15 | .167 | 38 | 360 | 5,759 | 6,673 | 35.8 | 53.1 |
More Lions Stats
Team Rankings
PPG
34.3
2nd
OPP PPG
26.0
23rd
RUSH YDS/G
149.0
4th
PASS YDS/G
253.7
9th
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
 Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
 Rams | 2 | 1 | 0 | .667 |
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