28 players are tied for the most interception touchdowns in a game, scoring 2 touchdowns. The first three are Kenny Moore II on November 5, 2023, Mike Edwards on September 19, 2021 and Zach Brown on December 30, 2012.

Interpreted as:

most pick-6 by a player 's in one regular-season game all-time

	NAME	INT TD	DATE	TM		OPP	TKL	AST	COMB	SCK	SCKY	INT	INT YDS	FF	FR	FR TD
1	Kenny Moore II K. Moore II	2	11/5/2023	IND	@	CAR	7	1	8	0.0	0	2	115	0	0	0
2	Mike Edwards M. Edwards	2	9/19/2021	TB	vs	ATL	4	0	4	0.0	0	2	46	0	0	0
3	Zach Brown Z. Brown	2	12/30/2012	TEN	vs	JAX	1	3	4	1.0	8	2	109	0	0	0
4	Janoris Jenkins J. Jenkins	2	11/25/2012	STL	@	ARI	2	0	2	0.0	0	2	75	0	0	0
5	David Bowens D. Bowens	2	10/24/2010	CLE	@	NO	1	0	1	0.0	0	2	94	0	0	0
6	Derrick Johnson D. Johnson	2	1/3/2010	KC	@	DEN	5	1	6	0.0	0	2	105	0	0	0
7	Antrel Rolle A. Rolle	2	11/18/2007	ARI	@	CIN	3	1	4	0.0	0	3	127	0	0	0
8	Ronde Barber R. Barber	2	10/22/2006	TB	vs	PHI	7	0	7	0.0	0	2	103	1	0	0
9	Aaron Glenn A. Glenn	2	12/8/2002	HOU	@	PIT	8	0	8	0.0	0	2	135	0	0	0
10	Dewayne Washington D. Washington	2	11/22/1998	PIT	vs	JAX				0.0		2	130			0
11	Otis Smith O. Smith	2	12/14/1997	NYJ	vs	TB				0.0		2	96			0
12	Ken Norton K. Norton	2	10/22/1995	SF	@	STL				0.0		2	56			0
13	Eric Allen E. Allen	2	12/26/1993	PHI	vs	NO				0.0		2	58			0
14	Robert Massey R. Massey	2	10/4/1992	PHX	vs	WAS				0.0		2	72			0
15	Henry Jones H. Jones	2	9/20/1992	BUF	vs	IND				0.0		2	105			0
16	Lloyd Burruss L. Burruss	2	10/19/1986	KC	vs	SD				0.0		3	121			0
17	Dave Brown D. Brown	2	11/4/1984	SEA	vs	KC				0.0		2	148			0
18	Mike Kozlowski M. Kozlowski	2	12/16/1983	MIA	vs	NYJ				0.0		2	73			0
19	Kenny Johnson K. Johnson	2	11/27/1983	ATL	vs	GB				0.0		2	57			0
20	Prentice McCray P. McCray	2	11/21/1976	NE	@	NYJ						2	118			0
21	Dick Anderson D. Anderson	2	12/3/1973	MIA	vs	PIT						4	121			0
22	Lemar Parrish L. Parrish	2	12/17/1972	CIN	@	HOU						3	90			0
23	Jim Kearney J. Kearney	2	10/1/1972	KC	@	DEN						2	75			0
24	Ken Houston K. Houston	2	12/19/1971	HOU	vs	SD						2	64			0
25	Miller Farr M. Farr	2	12/7/1968	HOU	vs	BUF						2	92			0

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Results may be incomplete. StatMuse has complete game-level data for interception touchdowns going back to the 1950 season.

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