The San Francisco 49ers have a 50-58 record against the AFC in the regular-season and playoffs since December 17, 1999.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2000 | 0-1 |  SF | vs |  OAK | L 28-34 | .000 | 4 | 28 | 472 | 471 | 60.0 | 0.0 |
| 2 | | 49ers | 11/12/2000 | 1-0 | SF | vs |  KC | W 21-7 | 1.000 | 3 | 25 | 389 | 294 | 50.0 | |
| 3 | | 49ers | 12/3/2000 | 1-0 | SF | @ |  SD | W 45-17 | 1.000 | 5 | 19 | 385 | 303 | 42.9 | 0.0 |
| 4 | | 49ers | 12/23/2000 | 0-1 | SF | @ |  DEN | L 9-38 | .000 | 1 | 16 | 192 | 362 | 28.6 | 66.7 |
| 5 | | 49ers | 10/1/2001 | 1-0 | SF | @ |  NYJ | W 19-17 | 1.000 | 1 | 21 | 359 | 268 | 54.5 | |
| 6 | | 49ers | 11/25/2001 | 1-0 | SF | @ |  IND | W 40-21 | 1.000 | 5 | 16 | 340 | 491 | 22.2 | |
| 7 | | 49ers | 12/2/2001 | 1-0 | SF | vs |  BUF | W 35-0 | 1.000 | 5 | 26 | 409 | 191 | 66.7 | 0.0 |
| 8 | | 49ers | 12/16/2001 | 1-0 | SF | vs |  MIA | W 21-0 | 1.000 | 3 | 21 | 285 | 174 | 50.0 | 50.0 |
| 9 | | 49ers | 9/15/2002 | 0-1 | SF | vs | DEN | L 14-24 | .000 | 2 | 18 | 261 | 299 | 61.5 | |
| 10 | | 49ers | 11/3/2002 | 1-0 | SF | @ | OAK | W 23-20 | 1.000 | 2 | 30 | 434 | 239 | 65.0 | 100.0 |
| 11 | | 49ers | 11/10/2002 | 1-0 | SF | vs | KC | W 17-13 | 1.000 | 2 | 22 | 323 | 256 | 61.1 | 100.0 |
| 12 | | 49ers | 11/17/2002 | 0-1 | SF | @ | SD | L 17-20 | .000 | 2 | 21 | 467 | 441 | 44.4 | 100.0 |
| 13 | | 49ers | 9/21/2003 | 0-1 | SF | vs |  CLE | L 12-13 | .000 | 0 | 15 | 265 | 251 | 33.3 | 0.0 |
| 14 | | 49ers | 11/17/2003 | 1-0 | SF | vs |  PIT | W 30-14 | 1.000 | 3 | 17 | 423 | 349 | 33.3 | 0.0 |
| 15 | | 49ers | 11/30/2003 | 0-1 | SF | @ |  BAL | L 6-44 | .000 | 0 | 10 | 264 | 282 | 26.7 | 0.0 |
| 16 | | 49ers | 12/14/2003 | 0-1 | SF | @ |  CIN | L 38-41 | .000 | 5 | 31 | 502 | 393 | 66.7 | |
| 17 | | 49ers | 10/17/2004 | 0-1 | SF | @ | NYJ | L 14-22 | .000 | 2 | 19 | 371 | 374 | 41.7 | |
| 18 | | 49ers | 11/28/2004 | 0-1 | SF | vs | MIA | L 17-24 | .000 | 2 | 16 | 224 | 200 | 31.3 | |
| 19 | | 49ers | 12/26/2004 | 0-1 | SF | vs | BUF | L 7-41 | .000 | 1 | 12 | 189 | 441 | 30.0 | 100.0 |
| 20 | | 49ers | 1/2/2005 | 0-1 | SF | @ |  NE | L 7-21 | .000 | 1 | 15 | 318 | 405 | 37.5 | 50.0 |
| 21 | | 49ers | 10/9/2005 | 0-1 | SF | vs | IND | L 3-28 | .000 | 0 | 12 | 177 | 365 | 21.4 | 100.0 |
| 22 | | 49ers | 11/27/2005 | 0-1 | SF | @ |  TEN | L 22-33 | .000 | 3 | 15 | 261 | 461 | 20.0 | 100.0 |
| 23 | | 49ers | 12/18/2005 | 0-1 | SF | @ |  JAX | L 9-10 | .000 | 0 | 11 | 217 | 336 | 7.7 | 0.0 |
| 24 | | 49ers | 1/1/2006 | 1-0 | SF | vs |  HOU | W 20-17 | 1.000 | 2 | 19 | 324 | 284 | 36.8 | |
| 25 | | 49ers | 10/1/2006 | 0-1 | SF | @ | KC | L 0-41 | .000 | 0 | 10 | 165 | 333 | 23.1 | |
| Average | .463 | 2.4 | 19.4 | 342.2 | 334.8 | 38.6 | 0.7 | ||||||||
| Total | 50-58 | .463 | 259 | 2,095 | 36,961 | 36,163 | 38.6 | 47.8 | |||||||
More 49ers Stats
Team Rankings
PPG
21.2
22nd
OPP PPG
19.6
6th
RUSH YDS/G
85.2
28th
PASS YDS/G
298.2
2nd
Rams 
Cardinals 
NYG 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 2 | 0 | .600 |
DAL 
NYJ 
