The San Francisco 49ers gained their most all-purpose yards in a game versus the Bills on October 7, 2012, with 621 yards.
Interpreted as:
san francisco 49ers most yards in a regular-season game all-time| TEAM | YDS | DATE | TM | OPP | RESULT | TD | PASS YDS | SCKY | PASS TD | RUSH YDS | RUSH TD | RET YDS | RET TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 621 | 10/7/2012 | vs | W 45-3 | 6 | 310 | 0 | 3 | 311 | 3 | 64 | 0 | ||
| 2 | | 49ers | 598 | 9/13/1992 | vs | L 31-34 | 4 | 449 | 10 | 3 | 159 | 1 | 75 | 0 | ||
| 3 | | 49ers | 597 | 12/13/1953 | vs | W 45-14 | 6 | 371 | 26 | 4 | 252 | 2 | 0 | |||
| 4 | | 49ers | 590 | 10/18/1992 | vs | W 56-17 | 8 | 399 | 0 | 3 | 191 | 5 | 38 | 0 | ||
| 5 | | 49ers | 580 | 9/25/1988 | @ | W 38-7 | 5 | 351 | 10 | 5 | 239 | 0 | 48 | 0 | ||
| 6 | | 49ers | 571 | 9/15/2019 | @ | W 41-17 | 5 | 312 | 0 | 3 | 259 | 2 | 17 | 0 | ||
| 7 | | 49ers | 565 | 12/19/1993 | @ | W 55-17 | 7 | 393 | 0 | 4 | 172 | 3 | 34 | 0 | ||
| 8 | | 49ers | 557 | 9/6/1998 | vs | W 36-30 | 5 | 363 | 13 | 3 | 207 | 2 | 129 | 0 | ||
| 9 | | 49ers | 555 | 10/15/1961 | @ | W 38-24 | 5 | 243 | 12 | 0 | 324 | 5 | 115 | 0 | ||
| 10 | | 49ers | 542 | 12/5/1999 | @ | L 30-44 | 4 | 437 | 0 | 3 | 105 | 1 | 86 | 0 | ||
| 11 | | 49ers | 539 | 11/28/1993 | @ | W 35-10 | 5 | 488 | 13 | 4 | 64 | 1 | 92 | 0 | ||
| 12 | | 49ers | 539 | 11/23/1958 | @ | W 33-12 | 4 | 283 | 0 | 3 | 256 | 1 | 0 | |||
| 13 | | 49ers | 538 | 9/27/1998 | vs | W 31-20 | 4 | 387 | 10 | 3 | 161 | 1 | 76 | 0 | ||
| 14 | | 49ers | 536 | 11/19/1961 | vs | W 41-31 | 5 | 322 | 4 | 3 | 218 | 2 | 92 | 0 | ||
| 15 | | 49ers | 534 | 9/10/1984 | vs | W 37-31 | 4 | 381 | 14 | 2 | 167 | 2 | 74 | 0 | ||
| 16 | | 49ers | 527 | 12/10/2023 | vs | W 28-16 | 4 | 368 | 14 | 2 | 173 | 2 | 69 | 0 | ||
| 17 | | 49ers | 527 | 9/18/1983 | @ | W 42-27 | 6 | 341 | 5 | 3 | 191 | 1 | 96 | 2 | ||
| 18 | | 49ers | 521 | 12/8/1984 | vs | W 51-7 | 6 | 346 | 9 | 3 | 184 | 3 | 88 | 0 | ||
| 19 | | 49ers | 521 | 10/8/1961 | vs | W 35-0 | 5 | 272 | 10 | 1 | 259 | 4 | 10 | 0 | ||
| 20 | | 49ers | 517 | 10/14/2001 | @ | W 37-31 | 5 | 332 | 2 | 3 | 187 | 2 | 153 | 0 | ||
| 21 | | 49ers | 517 | 10/21/1984 | @ | W 34-21 | 4 | 353 | 0 | 3 | 164 | 1 | 85 | 0 | ||
| 22 | | 49ers | 517 | 9/24/1967 | vs | W 38-7 | 5 | 353 | 16 | 2 | 180 | 3 | 95 | 0 | ||
| 23 | | 49ers | 516 | 12/8/2019 | @ | W 48-46 | 6 | 384 | 30 | 5 | 162 | 1 | 24 | 0 | ||
| 24 | | 49ers | 515 | 11/12/1989 | vs | W 45-3 | 6 | 286 | 6 | 3 | 235 | 2 | 127 | 1 | ||
| 25 | | 49ers | 510 | 10/3/1971 | @ | W 31-3 | 4 | 308 | 0 | 3 | 202 | 1 | 85 | 0 | ||
BAL
NYJ
RAM
CHI
WAS
STL
HOUMore 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
