The San Francisco 49ers had their most all-purpose yards in a game versus the Bills on October 7, 2012, with 621 yards.

Interpreted as:

san francisco 49ers most yards in a regular-season game all-time

	TEAM	YDS	DATE	TM		OPP	RESULT	TD	PASS YDS	SCKY	PASS TD	RUSH YDS	RUSH TD	RET YDS	RET TD
1	49ers	621	10/7/2012	SF	vs	BUF	W 45-3	6	310	0	3	311	3	64	0
2	49ers	598	9/13/1992	SF	vs	BUF	L 31-34	4	449	10	3	159	1	75	0
3	49ers	597	12/13/1953	SF	vs	BAL	W 45-14	6	371	26	4	252	2		0
4	49ers	590	10/18/1992	SF	vs	ATL	W 56-17	8	399	0	3	191	5	38	0
5	49ers	580	9/25/1988	SF	@	SEA	W 38-7	5	351	10	5	239	0	48	0
6	49ers	571	9/15/2019	SF	@	CIN	W 41-17	5	312	0	3	259	2	17	0
7	49ers	565	12/19/1993	SF	@	DET	W 55-17	7	393	0	4	172	3	34	0
8	49ers	557	9/6/1998	SF	vs	NYJ	W 36-30	5	363	13	3	207	2	129	0
9	49ers	555	10/15/1961	SF	@	MIN	W 38-24	5	243	12	0	324	5	115	0
10	49ers	542	12/5/1999	SF	@	CIN	L 30-44	4	437	0	3	105	1	86	0
11	49ers	539	11/28/1993	SF	@	RAM	W 35-10	5	488	13	4	64	1	92	0
12	49ers	539	11/23/1958	SF	@	GB	W 33-12	4	283	0	3	256	1		0
13	49ers	538	9/27/1998	SF	vs	ATL	W 31-20	4	387	10	3	161	1	76	0
14	49ers	536	11/19/1961	SF	vs	CHI	W 41-31	5	322	4	3	218	2	92	0
15	49ers	534	9/10/1984	SF	vs	WAS	W 37-31	4	381	14	2	167	2	74	0
16	49ers	527	12/10/2023	SF	vs	SEA	W 28-16	4	368	14	2	173	2	69	0
17	49ers	527	9/18/1983	SF	@	STL	W 42-27	6	341	5	3	191	1	96	2
18	49ers	521	12/8/1984	SF	vs	MIN	W 51-7	6	346	9	3	184	3	88	0
19	49ers	521	10/8/1961	SF	vs	LA	W 35-0	5	272	10	1	259	4	10	0
20	49ers	517	10/14/2001	SF	@	ATL	W 37-31	5	332	2	3	187	2	153	0
21	49ers	517	10/21/1984	SF	@	HOU	W 34-21	4	353	0	3	164	1	85	0
22	49ers	517	9/24/1967	SF	vs	ATL	W 38-7	5	353	16	2	180	3	95	0
23	49ers	516	12/8/2019	SF	@	NO	W 48-46	6	384	30	5	162	1	24	0
24	49ers	515	11/12/1989	SF	vs	ATL	W 45-3	6	286	6	3	235	2	127	1
25	49ers	510	10/3/1971	SF	@	PHI	W 31-3	4	308	0	3	202	1	85	0

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More 49ers Stats

Team Leaders

PASS

905

Jones

RUSH

282

McCaffrey

REC

387

McCaffrey

Team Rankings

PPG

21.2

22nd

OPP PPG

19.6

6th

RUSH YDS/G

85.2

28th

PASS YDS/G

298.2

2nd

2025 Division Standings

TEAM	W	L	PCT
49ers	4	1	.800
Rams	3	2	.600
Seahawks	3	2	.600
Cardinals	2	3	.400

Schedule

DATE	MATCHUP			TIME (ET)
Sun 10/12	SF	@	TB	4:25 PM
Sun 10/19	ATL	@	SF	8:20 PM
Sun 10/26	SF	@	HOU	1:00 PM
Sun 11/2	SF	@	NYG	1:00 PM
Sun 11/9	LAR	@	SF	4:25 PM

Last Game

Rams

3 - 2 - 0

Final

49ers

4 - 1 - 0

Thu 2 Oct 2025

NFL 2025 Leaders

Pass Yards Leaders

1,503

Stafford

1,356

Prescott

1,290

Jones

Rush Yards Leaders

480

Taylor

450

Cook

447

Williams

Rec Yards Leaders

588

Nacua

534

Smith-Njigba

449

Jefferson

Pass TD Leaders

12

Goff

11

Stafford

10

Tagovailoa

Rush TD Leaders

6

Taylor

5

Cook

5

Williams

Rec TD Leaders

6

St. Brown

5

Egbuka

5

Odunze

QB Rating Leaders

130.5

Jackson

120.7

Goff

114.8

Darnold

Sack Leaders

7.0

Bonitto

5.5

Young

5.0

Hutchinson

NFL 2025 Rankings

PPG Rankings

34.8

32.6

30.6

30.2

29.2

28.2

Opp PPG Rankings

12.2

16.8

17.8

19.2

19.4

19.6

Total Yards Rankings

406.6

401.8

395.8

381.2

375.8

365.0

Rush Yards Rankings

156.4

154.4

144.4

140.6

137.0

136.5

Pass Yards Rankings

300.6

298.2

279.4

259.8

256.6

254.6

Sack Leaders

21.0

16.0

15.0

14.0

NFL Fantasy 2025

Fantasy RB Rankings

105.3

Taylor

86.5

Williams

84.9

McCaffrey

Fantasy WR Rankings

82

Nacua

77.4

Egbuka

77.4

St. Brown

Fantasy TE Rankings

46.7

Kincaid

45.2

Ferguson

43.3

Warren

Fantasy K Rankings

57

Shrader

57

McLaughlin

56

Aubrey

NFL 2025 Betting

Best Record ATS

4-1

3-2

Worst Record ATS

1-4

2-3

NFL 2025 Division Standings

NFC East	W	L	T	PCT
Eagles	4	1	0	.800
Commanders	3	2	0	.600
NFC North	W	L	T	PCT
Lions	4	1	0	.800
Packers	2	1	1	.625
NFC South	W	L	T	PCT
Buccaneers	4	1	0	.800
Falcons	2	2	0	.500
NFC West	W	L	T	PCT
49ers	4	1	0	.800
Seahawks	3	2	0	.600

AFC East	W	L	T	PCT
Bills	4	1	0	.800
Patriots	3	2	0	.600
AFC North	W	L	T	PCT
Steelers	3	1	0	.750
Bengals	2	3	0	.400
AFC South	W	L	T	PCT
Colts	4	1	0	.800
Jaguars	4	1	0	.800
AFC West	W	L	T	PCT
Chargers	3	2	0	.600
Broncos	3	2	0	.600