The San Francisco 49ers have a 68-44 record against the AFC in the regular-season and playoffs at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/27/1970 | 1-0 |  SF | vs |  CLE | W 34-31 | 1.000 | 5 | 24 | 435 | 448 | ||
| 2 | | 49ers | 10/25/1970 | 1-0 | SF | vs |  DEN | W 19-14 | 1.000 | 1 | 16 | 362 | 283 | ||
| 3 | | 49ers | 10/31/1971 | 1-0 | SF | vs |  NE | W 27-10 | 1.000 | 3 | 13 | 247 | 246 | ||
| 4 | | 49ers | 12/6/1971 | 0-1 | SF | vs |  KC | L 17-26 | .000 | 2 | 18 | 331 | 427 | ||
| 5 | | 49ers | 9/17/1972 | 1-0 | SF | vs |  SD | W 34-3 | 1.000 | 4 | 18 | 295 | 258 | ||
| 6 | | 49ers | 11/12/1972 | 1-0 | SF | vs |  BAL | W 24-21 | 1.000 | 3 | 19 | 310 | 297 | ||
| 7 | | 49ers | 12/15/1973 | 0-1 | SF | vs |  PIT | L 14-37 | .000 | 2 | 16 | 239 | 308 | ||
| 8 | | 49ers | 9/29/1974 | 0-1 | SF | vs |  CIN | L 3-21 | .000 | 0 | 14 | 226 | 373 | ||
| 9 | | 49ers | 10/27/1974 | 0-1 | SF | vs |  OAK | L 24-35 | .000 | 3 | 20 | 372 | 297 | ||
| 10 | | 49ers | 12/7/1975 | 0-1 | SF | vs |  HOU | L 13-27 | .000 | 1 | 11 | 200 | 279 | ||
| 11 | | 49ers | 10/3/1976 | 1-0 | SF | vs |  NYJ | W 17-6 | 1.000 | 2 | 16 | 247 | 261 | ||
| 12 | | 49ers | 9/25/1977 | 0-1 | SF | vs |  MIA | L 15-19 | .000 | 2 | 13 | 280 | 361 | ||
| 13 | | 49ers | 10/1/1978 | 1-0 | SF | vs | CIN | W 28-12 | 1.000 | 4 | 11 | 179 | 322 | ||
| 14 | | 49ers | 11/27/1978 | 0-1 | SF | vs | PIT | L 7-24 | .000 | 1 | 12 | 141 | 380 | ||
| 15 | | 49ers | 10/7/1979 | 0-1 | SF | vs |  SEA | L 24-35 | .000 | 3 | 29 | 464 | 310 | ||
| 16 | | 49ers | 11/18/1979 | 0-1 | SF | vs | DEN | L 28-38 | .000 | 4 | 18 | 240 | 369 | ||
| 17 | | 49ers | 11/30/1980 | 1-0 | SF | vs | NE | W 21-17 | 1.000 | 3 | 15 | 229 | 343 | ||
| 18 | | 49ers | 12/21/1980 | 0-1 | SF | vs |  BUF | L 13-18 | .000 | 2 | 19 | 298 | 267 | ||
| 19 | | 49ers | 11/15/1981 | 0-1 | SF | vs | CLE | L 12-15 | .000 | 0 | 21 | 305 | 267 | ||
| 20 | | 49ers | 12/13/1981 | 1-0 | SF | vs | HOU | W 28-6 | 1.000 | 4 | 22 | 414 | 186 | ||
| 21 | | 49ers | 9/12/1982 | 0-1 | SF | vs | RAI | L 17-23 | .000 | 2 | 18 | 252 | 255 | ||
| 22 | | 49ers | 12/11/1982 | 0-1 | SF | vs | SD | L 37-41 | .000 | 5 | 29 | 465 | 538 | ||
| 23 | | 49ers | 10/30/1983 | 0-1 | SF | vs | NYJ | L 13-27 | .000 | 1 | 17 | 312 | 364 | ||
| 24 | | 49ers | 11/6/1983 | 0-1 | SF | vs | MIA | L 17-20 | .000 | 2 | 20 | 394 | 316 | ||
| 25 | | 49ers | 10/14/1984 | 0-1 | SF | vs | PIT | L 17-20 | .000 | 2 | 22 | 358 | 324 | ||
| Average | .607 | 2.8 | 20.2 | 353.7 | 313.6 | ||||||||||
| Total | 68-44 | .607 | 313 | 2,267 | 39,618 | 35,127 | |||||||||
More 49ers Stats
Team Rankings
PPG
23.7
11th
OPP PPG
23.7
21st
RUSH YDS/G
138.9
7th
PASS YDS/G
248.5
9th
Cardinals 
NFL 2024 Leaders
NFL 2024 Rankings
NFL Fantasy 2024
NFL 2024 Betting
NFL 2024 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 11 | 2 | 0 | .846 |
 Commanders | 8 | 5 | 0 | .615 |
| NFC North | W | L | T | PCT |
 Lions | 12 | 1 | 0 | .923 |
 Vikings | 11 | 2 | 0 | .846 |
| NFC South | W | L | T | PCT |
 Buccaneers | 7 | 6 | 0 | .538 |
 Falcons | 6 | 7 | 0 | .462 |
| NFC West | W | L | T | PCT |
| Seahawks | 8 | 5 | 0 | .615 |
 Rams | 7 | 6 | 0 | .538 |
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