James Cook III has the most career total touchdowns by an active player against the Patriots, with 7 touchdowns.
| NAME | TD | GP | RUSH TD | REC TD | RET TD | FGM | XPM | XP2 | SFTY | PTS | PPG | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 7 | 8 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 42 | 5.3 |
| 2 |  | J. Waddle | 6 | 9 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 36 | 4.0 |
| 3 |  | J. Allen | 5 | 15 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 30 | 2.0 |
| 4 |  | D. Knox | 4 | 12 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 26 | 2.2 |
| 5 |  | D. Henry | 4 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 12.0 |
| 6 |  | D. London | 3 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 18 | 18.0 |
| 7 |  | B. Hall | 3 | 6 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 20 | 3.3 |
| 8 |  | D. Achane | 3 | 4 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 18 | 4.5 |
| 9 |  | J. Taylor | 3 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 18 | 6.0 |
| 10 |  | C. Lamb | 3 | 2 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 18 | 9.0 |
| 11 |  | T. Tagovailoa | 3 | 8 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 2.3 |
| 12 |  | C. Kupp | 3 | 2 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 18 | 9.0 |
| 13 |  | DK Metcalf | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 18 | 6.0 |
| 14 |  | D. Singletary | 3 | 8 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 2.3 |
| 15 |  | L. Jackson | 3 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 4.5 |
| 16 |  | T. Conklin | 3 | 7 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 18 | 2.6 |
| 17 |  | J. Conner | 3 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 4.5 |
| 18 | | T. Johnson | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 | 12.0 |
| 19 |  | L. McConkey | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 | 12.0 |
| 20 | | T. Bigsby | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 12.0 |
| 21 | | M. Washington | 2 | 4 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 12 | 3.0 |
| 22 |  | J. Fields | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 6.0 |
| 23 | | N. Westbrook-Ikhine | 2 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 | 3.0 |
| 24 | | F. Moreau | 2 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 | 3.0 |
| 25 |  | M. Hardman Jr. | 2 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 12 | 4.0 |
StatMuse has game-level data for touchdowns going back to the 1950 season.
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
