Between the 2017-18 and 2021-22 seasons, Connor McDavid made the most assists, with 356 assists.

Interpreted as:

most assists by a player 2017-18 to 2021-22

	NAME	A	GP	G	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Connor McDavid C. McDavid	356	360	193	549	+65	139	44	133	2	5	42	11	1,240	15.6	2,002	4,181	47.9	240	144	372	346	22:06
2	Artemi Panarin A. Panarin	292	346	126	418	+108	93	30	88	0	0	23	6	911	13.8	3	18	16.7	89	75	234	286	19:54
3	Jonathan Huberdeau J. Huberdeau	285	368	130	415	+37	192	33	111	3	2	20	4	926	14.0	92	217	42.4	299	152	239	370	18:58
4	Patrick Kane P. Kane	283	367	145	428	-36	126	34	94	0	0	18	6	1,379	10.5	15	42	35.7	87	92	207	222	21:35
5	Leon Draisaitl L. Draisaitl	275	367	204	479	+33	162	77	80	8	1	35	7	1,089	18.7	3,471	6,499	53.4	214	106	339	450	21:47
6	Nathan MacKinnon N. MacKinnon	275	338	167	442	+89	180	51	101	0	1	29	7	1,472	11.3	1,986	4,517	44.0	249	138	175	243	21:00
7	Mitch Marner M. Marner	275	350	119	394	+71	100	23	88	4	6	19	2	961	12.4	78	155	50.3	182	177	352	320	19:56
8	Johnny Gaudreau J. Gaudreau	268	370	137	405	+76	94	28	85	0	0	28	7	1,055	13.0	4	14	28.6	47	59	215	435	19:06
9	Brad Marchand B. Marchand	262	340	159	421	+107	382	34	96	11	12	33	10	983	16.2	142	358	39.7	282	94	242	329	19:25
10	John Carlson J. Carlson	258	361	70	328	+41	124	19	112	0	3	14	1	934	7.5	0	2	0.0	281	599	221	340	24:28
11	Blake Wheeler B. Wheeler	256	349	97	353	-18	235	19	111	3	4	11	0	937	10.4	529	1,131	46.8	402	237	170	186	19:46
12	Sidney Crosby S. Crosby	247	326	135	382	+37	155	38	98	1	2	27	10	943	14.3	3,968	7,361	53.9	282	161	207	276	20:31
13	Jakub Voracek J. Voracek	245	361	67	312	-17	168	15	88	0	0	12	4	821	8.2	46	134	34.3	101	130	156	231	18:01
14	Nikita Kucherov N. Kucherov	244	277	138	382	+66	164	36	103	0	0	22	3	891	15.5	4	10	40.0	144	72	178	264	19:39
15	Aleksander Barkov A. Barkov	235	344	147	382	+57	72	44	69	10	3	21	6	1,024	14.4	3,878	7,117	54.5	160	242	331	258	21:14
16	Claude Giroux C. Giroux	234	362	114	348	+35	110	24	89	2	1	13	2	944	12.1	3,192	5,403	59.1	203	80	164	184	19:45
17	Victor Hedman V. Hedman	233	349	69	302	+114	193	15	120	0	3	16	5	908	7.6	1	3	33.3	415	507	189	241	24:35
18	Steven Stamkos S. Stamkos	230	336	160	390	+64	183	70	73	2	1	25	3	954	16.8	2,120	4,001	53.0	333	154	114	174	18:28
19	Roman Josi R. Josi	227	354	76	303	+57	173	25	81	0	3	13	3	1,209	6.3	0	1	0.0	278	588	163	293	25:07
20	Mikko Rantanen M. Rantanen	225	324	145	370	+76	192	61	80	0	0	21	1	909	16.0	317	656	48.3	203	167	198	146	20:01
21	Brent Burns B. Burns	221	372	57	278	-53	192	23	73	1	8	10	4	1,198	4.8	0	2	0.0	327	600	316	462	25:35
22	Anze Kopitar A. Kopitar	221	370	110	331	-6	90	24	88	3	3	22	1	819	13.4	4,280	7,705	55.5	275	294	210	241	21:31
23	Mathew Barzal M. Barzal	220	360	91	311	+1	186	14	71	0	0	11	2	815	11.2	1,210	2,817	43.0	126	160	272	435	18:26
24	Evgeny Kuznetsov E. Kuznetsov	214	338	100	314	+22	200	30	70	4	2	19	4	795	12.6	1,905	4,503	42.3	194	105	182	243	18:42
25	J.T. Miller	212	359	110	322	+23	207	35	84	1	4	22	8	728	15.1	2,067	3,806	54.3	624	167	222	255	18:36