Alessandro Altobelli has scored the most career goals by an Inter player in Serie A versus Roma, with 15 goals.

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Alessandro Altobelli A. Altobelli	15	22	1,920	21	0.68			4
2	Giuseppe Meazza G. Meazza	11	19	1,710	19	0.58			0
3	Carlo Gino Muraro C. Gino Muraro	7	10	790	9	0.70			0
4	Roberto Boninsegna R. Boninsegna	7	11	990	11	0.64			1
5	Christian Vieri C. Vieri	6	9	752	8	0.67			0
6	Alessandro Mazzola A. Mazzola	6	27	2,372	27	0.22			1
7	Antonio Valentín Angelillo A. Valentín Angelillo	6	6	540	6	1.00			1
8	Mauro Icardi M. Icardi	5	10	703	7	0.50	1	6	0
9	Álvaro Alexánder Recoba Á. Alexánder Recoba	5	10	662	8	0.50			0
10	Umberto Visentin U. Visentin	5	7	630	7	0.71			1
11	Ronaldo	4	4	316	4	1.00			0
12	Lothar Matthäus L. Matthäus	4	7	630	7	0.57			1
13	Mario Bertini M. Bertini	4	13	1,131	13	0.31			2
14	Angelo Domenghini A. Domenghini	4	9	810	9	0.44			0
15	Servaas Wilkes S. Wilkes	4	4	360	4	1.00			0
16	Istvan Nyers I. Nyers	4	6	540	6	0.67			1
17	Benito Lorenzi B. Lorenzi	4	19	1,665	19	0.21			0
18	Pietro Ferraris P. Ferraris	4	10	900	10	0.40			0
19	Alfredo De Vincenzi A. De Vincenzi	4	3	270	3	1.33			0
20	Atilio José Demaría A. José Demaría	4	16	1,440	16	0.25			0
21	Romelu Lukaku R. Lukaku	3	5	383	4	0.60	1	4	1	0	13	5	0	144	28	2
22	Matías Vecino M. Vecino	3	7	443	5	0.43	0	3	0	0	10	5	0	324	20	2
23	Samuel Eto'o S. Eto'o	3	4	360	4	0.75	1	4	1
24	Zlatan Ibrahimovic Z. Ibrahimovic	3	4	314	4	0.75			1
25	Hernán Crespo H. Crespo	3	5	320	3	0.60			0