Between the 1999-00 and 2008-09 seasons, Thierry Henry scored the most goals in the Premier League in a decade, with 174 goals in the 2000s.

	NAME	G	DECADE	M	MIN	START	G/M	A	G+A	PK
1	Thierry Henry T. Henry	174	2000s	254	21,219	235	0.69	74	248	23
2	Robbie Keane R. Keane	115	2000s	307	22,134	246	0.37	35	150	16
3	Alan Shearer A. Shearer	107	2000s	225	19,550	220	0.48	25	132	28
4	Michael Owen M. Owen	107	2000s	219	16,372	186	0.49	16	123	11
5	Frank Lampard F. Lampard	97	2000s	348	30,526	342	0.28	71	168	19
6	Ruud van Nistelrooy R. van Nistelrooy	95	2000s	150	12,181	137	0.63	14	109	18
7	Jimmy Floyd Hasselbaink J. Floyd Hasselbaink	93	2000s	219	15,812	178	0.42	39	132	13
8	Mark Viduka M. Viduka	92	2000s	240	18,233	207	0.38	28	120	5
9	Kevin Phillips K. Phillips	87	2000s	226	18,432	208	0.38	24	111	11
10	Cristiano Ronaldo C. Ronaldo	84	2000s	196	14,544	157	0.43	34	118	11
11	Andy Cole A. Cole	83	2000s	219	15,964	176	0.38	34	117	1
12	James Beattie J. Beattie	83	2000s	261	18,295	206	0.32	26	109	15
13	Nicolas Anelka N. Anelka	82	2000s	213	17,379	196	0.38	24	106	7
14	Wayne Rooney W. Rooney	80	2000s	224	16,663	181	0.36	46	126	0
15	Jermain Defoe J. Defoe	79	2000s	252	16,024	166	0.31	19	98	7
16	Emile Heskey E. Heskey	77	2000s	337	25,641	300	0.23	36	113	0
17	Yakubu Aiyegbeni Y. Aiyegbeni	72	2000s	183	14,803	171	0.39	19	91	14
18	Steven Gerrard S. Gerrard	71	2000s	321	26,440	304	0.22	55	126	11
19	Paul Scholes P. Scholes	66	2000s	287	22,466	252	0.23	33	99	1
20	Craig Bellamy C. Bellamy	64	2000s	213	16,862	192	0.30	19	83	3
21	Robert Pirès R. Pirès	62	2000s	189	13,977	159	0.33	41	103	4
22	Louis Saha L. Saha	60	2000s	184	11,683	123	0.33	17	77	10
23	Teddy Sheringham T. Sheringham	59	2000s	201	13,733	149	0.29	26	85	9
24	Kevin Davies K. Davies	57	2000s	292	23,127	265	0.20	37	94	0
25	Robbie Fowler R. Fowler	57	2000s	194	12,102	134	0.29	16	73	6