5 players are tied for having the most goals in a Premier League match, with 5 goals. The first three are Sergio Agüero on October 3, 2015, Dimitar Berbatov on November 27, 2010 and Jermain Defoe on November 22, 2009.

	NAME	G	DATE	CLUB		OPP	Rating	MIN	A	xG	xA	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF	FOUL	YC	RC
1	Sergio Agüero S. Agüero	5	10/3/2015	Man City	vs	Newcastle		66	0			0	0	8	5	1	36	0	1	0	0	0
2	Dimitar Berbatov D. Berbatov	5	11/27/2010	Man United	vs	Rovers		90	0			0									0	0
3	Jermain Defoe J. Defoe	5	11/22/2009	Tottenham	vs	Wigan Athletic		90	0			0									0	0
4	Alan Shearer A. Shearer	5	9/19/1999	Newcastle	vs	Sheffield Wed		90	1			2									0	0
5	Andy Cole A. Cole	5	3/4/1995	Man United	vs	Ipswich		90	0			0									0	0
6	Cole Palmer C. Palmer	4	9/28/2024	Chelsea	vs	Brighton	9.8	90	0	2.41	0.62	1	1	7	5	0	44	6	2	0	0	0
7	Erling Haaland E. Haaland	4	5/4/2024	Man City	vs	Wolves	9.8	82	0	2.11	0.06	2	0	8	7	0	32	10	1	0	0	0
8	Cole Palmer C. Palmer	4	4/15/2024	Chelsea	vs	Everton	9.9	80	0	2.50	0.06	1	0	5	5	0	50	6	0	0	0	0
9	Kevin De Bruyne K. De Bruyne	4	5/11/2022	Man City	@	Wolves	9.8	90	0	0.74	0.17	0	0	6	4	1	73	6	0	2	1	0
10	Gabriel Jesus G. Jesus	4	4/23/2022	Man City	vs	Watford	9.8	90	1	2.45	0.23	1	0	6	4	0	61	11	0	1	0	0
11	Son Heung-min S. Heung-min	4	9/20/2020	Tottenham	@	Southampton		90	0			0	0	4	4	0	40	6	4	0	0	0
12	Michail Antonio M. Antonio	4	7/11/2020	West Ham	@	Norwich City		78	0			0	0	9	6	0	44	14	0	1	0	0
13	Mohamed Salah M. Salah	4	3/17/2018	Liverpool	vs	Watford		90	1			0	0	4	4	0	56	13	1	1	0	0
14	Sergio Agüero S. Agüero	4	2/10/2018	Man City	vs	Leicester		90	0			0	0	7	4	0	49	9	0	0	0	0
15	Harry Kane H. Kane	4	5/18/2017	Tottenham	@	Leicester		90	1			0	0	10	5	0	51	8	0	0	0	0
16	Romelu Lukaku R. Lukaku	4	2/4/2017	Everton	vs	Bournemouth		90	0			0	0	5	4	0	53	14	3	0	0	0
17	Georginio Wijnaldum G. Wijnaldum	4	10/18/2015	Newcastle	vs	Norwich City		90	0			0	0	5	4	0	59	0	0	1	0	0
18	Sergio Agüero S. Agüero	4	10/18/2014	Man City	vs	Tottenham		90	0			2	0	11	8	0	51	0	1	0	0	0
19	Luis Suárez L. Suárez	4	12/4/2013	Liverpool	vs	Norwich City		90	1			0									0	0
20	Yakubu Aiyegbeni Y. Aiyegbeni	4	12/3/2011	Rovers	vs	Swansea		87	0			1									0	0
21	Edin Džeko E. Džeko	4	8/28/2011	Man City	@	Tottenham		90	0			0									0	0
22	Louis Saha L. Saha	4	2/5/2011	Everton	vs	Blackpool		86	0			0									0	0
23	Frank Lampard F. Lampard	4	3/27/2010	Chelsea	vs	Aston Villa		90	1			2									0	0
24	Wayne Rooney W. Rooney	4	1/23/2010	Man United	vs	Hull City		90	0			0									1	0
25	Robbie Keane R. Keane	4	9/26/2009	Tottenham	vs	Burnley		90	0			1									0	0