Carlos Rodón had the lowest ERA in the AL with 130.0+ innings pitched in 2021, with an ERA of 2.37.

	NAME	ERA	IP	SEASON	TM	G	W	L	W%	GS	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Carlos Rodón C. Rodón	2.37	132.2	2021	CWS	24	13	5	.722	24	185	1	1	0	91	35	39	13	36	8	0	1	534	7	12.55	2.44	5.14	0.88	34.6	6.7	0.96	.267	2.65	54	2.64	59	6.17	25.8
2	Lance Lynn L. Lynn	2.69	157.0	2021	CWS	28	11	6	.647	28	176	1	1	0	123	47	52	18	45	2	0	2	641	5	10.09	2.58	3.91	1.03	27.5	7.0	1.07	.263	2.98	62	3.31	74	7.05	19.4
3	Robbie Ray R. Ray	2.84	193.1	2021	TOR	32	13	7	.650	32	248	0	0	0	150	61	62	33	52	4	0	0	773	5	11.54	2.42	4.77	1.54	32.1	6.7	1.04	.268	2.89	63	3.68	87	6.98	11.8
4	Cal Quantrill C. Quantrill	2.89	149.2	2021	CLE	40	8	3	.727	22	121	0	0	0	129	48	55	16	47	9	2	0	616	3	7.28	2.83	2.57	0.96	19.6	7.6	1.18	.267	3.31	68	4.06	97	7.76	2.1
5	Framber Valdez F. Valdez	3.14	134.2	2021	HOU	22	11	6	.647	22	125	1	0	0	110	47	52	12	58	11	0	1	572	9	8.35	3.88	2.16	0.80	21.9	10.1	1.25	.268	3.48	73	4.00	95	7.35	3.4
6	Chris Bassitt C. Bassitt	3.15	157.1	2021	OAK	27	12	4	.750	27	159	1	1	0	127	55	55	15	39	11	0	1	637	5	9.10	2.23	4.08	0.86	25.0	6.1	1.06	.271	3.15	77	3.33	80	7.26	14.5
7	Lance McCullers Jr. L. McCullers Jr.	3.16	162.1	2021	HOU	28	13	5	.722	28	185	0	0	0	122	57	59	13	76	10	0	0	684	7	10.26	4.21	2.43	0.72	27.0	11.1	1.22	.273	3.27	74	3.51	83	6.76	13
8	Shohei Ohtani S. Ohtani	3.18	130.1	2021	LAA	23	9	2	.818	23	156	0	0	0	98	46	48	15	44	10	0	2	533	10	10.77	3.04	3.55	1.04	29.3	8.3	1.09	.269	3.31	72	3.51	80	6.77	12.2
9	Gerrit Cole G. Cole	3.23	181.1	2021	NYY	30	16	8	.667	30	243	2	1	0	151	65	69	24	41	2	0	0	726	5	12.06	2.03	5.93	1.19	33.5	5.6	1.06	.305	3.42	76	2.91	67	7.49	28.1
10	Frankie Montas F. Montas	3.37	187.0	2021	OAK	32	13	9	.591	32	207	0	0	0	164	70	79	20	57	7	0	1	778	11	9.96	2.74	3.63	0.96	26.6	7.3	1.18	.296	3.80	82	3.37	81	7.89	16.5
11	Luis Garcia L. Garcia	3.48	155.1	2021	HOU	30	11	8	.579	28	167	0	0	0	133	60	62	19	50	3	1	1	633	9	9.68	2.90	3.34	1.10	26.4	7.9	1.18	.289	3.59	81	3.63	86	7.71	10.5
12	José Berríos J. Berríos	3.52	192.0	2021	TOT	32	12	9	.571	32	204	1	0	0	159	75	83	22	45	15	0	0	781	3	9.56	2.11	4.53	1.03	26.1	5.8	1.06	.277	3.89	81	3.46	82	7.45	16.5
13	Lucas Giolito L. Giolito	3.53	178.2	2021	CWS	31	11	9	.550	31	201	1	0	0	145	70	74	27	52	2	0	1	720	12	10.13	2.62	3.87	1.36	27.9	7.2	1.10	.269	3.73	81	3.78	85	7.30	13
14	Chris Flexen C. Flexen	3.61	179.2	2021	SEA	31	14	6	.700	31	125	0	0	0	185	72	74	19	40	4	0	0	741	2	6.26	2.00	3.13	0.95	16.9	5.4	1.25	.300	3.71	87	3.88	94	9.27	5.3
15	John Means J. Means	3.62	146.2	2021	BAL	26	6	9	.400	26	134	1	1	0	125	59	64	30	26	4	0	0	590	3	8.22	1.60	5.15	1.84	22.7	4.4	1.03	.240	3.93	82	4.61	102	7.67	-0.8
16	Casey Mize C. Mize	3.71	150.1	2021	DET	30	7	9	.438	30	118	1	0	0	130	62	64	24	41	11	0	0	612	7	7.06	2.45	2.88	1.44	19.3	6.7	1.14	.254	3.83	86	4.71	111	7.78	-8
17	Nathan Eovaldi N. Eovaldi	3.75	182.1	2021	BOS	32	11	9	.550	32	195	0	0	0	182	76	81	15	35	7	0	2	764	6	9.63	1.73	5.57	0.74	25.5	4.6	1.19	.326	4.00	82	2.78	64	8.98	30.9
18	Steven Matz S. Matz	3.82	150.2	2021	TOR	29	14	7	.667	29	144	0	0	0	158	64	70	18	43	6	0	0	647	5	8.60	2.57	3.35	1.08	22.3	6.6	1.33	.321	4.18	85	3.78	89	9.44	7.6
19	Jordan Montgomery J. Montgomery	3.83	157.1	2021	NYY	30	6	7	.462	30	162	0	0	0	150	67	73	19	51	2	0	0	661	12	9.27	2.92	3.18	1.09	24.5	7.7	1.28	.307	4.18	91	3.68	85	8.58	11.1
20	Dylan Cease D. Cease	3.91	165.2	2021	CWS	32	13	7	.650	32	226	1	1	0	139	72	77	20	68	9	0	0	708	13	12.28	3.69	3.32	1.09	31.9	9.6	1.25	.309	4.18	90	3.40	76	7.55	18.9
21	Sean Manaea S. Manaea	3.91	179.1	2021	OAK	32	11	10	.524	32	194	2	2	0	179	78	79	25	41	9	0	0	754	5	9.74	2.06	4.73	1.25	25.7	5.4	1.23	.318	3.96	95	3.65	88	8.98	10
22	Marco Gonzales M. Gonzales	3.96	143.1	2021	SEA	25	10	6	.625	25	108	1	0	0	125	63	64	29	42	5	0	3	585	1	6.78	2.64	2.57	1.82	18.5	7.2	1.17	.239	4.02	95	5.27	127	7.85	-18.6
23	Zack Greinke Z. Greinke	4.16	171.0	2021	HOU	30	11	6	.647	29	120	1	0	0	164	79	82	30	36	2	0	0	697	3	6.32	1.89	3.33	1.58	17.2	5.2	1.17	.263	4.32	97	4.71	111	8.63	-9.1
24	Cole Irvin C. Irvin	4.24	178.1	2021	OAK	32	10	15	.400	32	125	0	0	0	195	84	94	23	42	9	0	0	768	3	6.31	2.12	2.98	1.16	16.3	5.5	1.33	.302	4.74	103	4.29	104	9.84	-3.2
25	Jameson Taillon J. Taillon	4.30	144.1	2021	NYY	29	8	6	.571	29	140	0	0	0	130	69	73	24	44	6	0	1	603	4	8.73	2.74	3.18	1.50	23.2	7.3	1.21	.272	4.55	102	4.42	102	8.11	-1.6