Since 2016, the Los Angeles Dodgers have the highest run differential by a team in a season, with a differential of 334 runs in 2022.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	334	2022	162	.685	111	51	5,526	847	1,418	325	31	212	812	607	56	1,374	98	18	6,245	2,441	568	3	53	22	85	.257	.333	.442	.775
2	Astros	280	2019	162	.660	107	55	5,613	920	1,538	323	28	288	891	645	66	1,166	67	27	6,391	2,781	639	10	57	17	146	.274	.352	.495	.848
3	Dodgers	273	2019	162	.654	106	56	5,493	886	1,414	302	20	279	861	607	81	1,356	57	10	6,281	2,593	601	55	45	47	100	.257	.338	.472	.810
4	Dodgers	269	2021	162	.654	106	56	5,445	830	1,330	247	24	237	799	613	104	1,408	65	17	6,239	2,336	508	32	45	36	96	.244	.330	.429	.759
5	Astros	263	2018	162	.636	103	59	5,453	797	1,390	278	18	205	763	565	61	1,197	71	26	6,138	2,319	501	14	45	19	156	.255	.329	.425	.754
6	Indians	254	2017	162	.630	102	60	5,511	818	1,449	333	29	212	780	604	50	1,153	88	23	6,233	2,476	574	23	45	30	125	.263	.339	.449	.788
7	Cubs	252	2016	162	.640	103	58	5,503	808	1,409	293	30	199	767	656	96	1,339	66	34	6,334	2,359	522	42	37	45	107	.256	.343	.429	.772
8	Yankees	240	2022	162	.611	99	63	5,422	807	1,308	225	8	254	764	620	70	1,391	102	33	6,167	2,311	487	14	41	36	121	.241	.325	.426	.751
9	Braves	231	2023	162	.642	104	58	5,597	947	1,543	293	23	307	916	538	67	1,289	132	27	6,247	2,803	623	2	43	20	128	.276	.344	.501	.845
10	Red Sox	229	2018	162	.667	108	54	5,623	876	1,509	355	31	208	829	569	55	1,253	125	31	6,302	2,550	594	7	48	38	130	.268	.339	.453	.792
11	Astros	219	2022	162	.654	106	56	5,409	737	1,341	284	13	214	715	528	60	1,179	83	22	6,048	2,293	511	9	42	18	118	.248	.319	.424	.743
12	Giants	210	2021	162	.660	107	55	5,462	804	1,360	271	25	241	768	602	64	1,461	66	14	6,194	2,404	537	36	30	45	117	.249	.329	.440	.769
13	Dodgers	207	2023	162	.617	100	62	5,524	906	1,423	304	20	249	877	644	85	1,359	105	25	6,327	2,514	573	5	69	29	98	.258	.340	.455	.796
14	Rays	206	2021	162	.617	100	62	5,507	857	1,336	288	36	222	810	585	72	1,542	88	42	6,211	2,362	546	6	41	27	75	.243	.321	.429	.750
15	Astros	205	2021	162	.586	95	67	5,593	863	1,496	299	14	221	834	569	64	1,222	53	16	6,289	2,486	534	9	54	25	136	.267	.339	.444	.783
16	Yankees	204	2019	162	.636	103	59	5,583	943	1,493	290	17	306	904	569	49	1,437	55	22	6,244	2,735	613	10	33	18	113	.267	.339	.490	.829
17	Yankees	198	2017	162	.562	91	71	5,594	858	1,463	266	23	241	821	616	64	1,386	90	22	6,348	2,498	530	18	56	22	119	.262	.339	.447	.785
18	Astros	196	2017	162	.623	101	61	5,611	896	1,581	346	20	238	854	509	70	1,087	98	42	6,262	2,681	604	11	61	27	139	.282	.346	.478	.823
19	Rays	195	2023	162	.611	99	63	5,511	860	1,432	282	24	230	827	514	95	1,420	160	41	6,164	2,452	536	6	38	7	109	.260	.331	.445	.776
20	Dodgers	194	2018	163	.564	92	71	5,572	804	1,394	296	33	235	756	647	61	1,436	75	24	6,358	2,461	564	39	39	47	119	.250	.333	.442	.774
21	Dodgers	190	2017	162	.642	104	58	5,408	770	1,347	312	20	221	730	649	64	1,380	77	28	6,190	2,362	553	31	38	41	119	.249	.334	.437	.771
22	Twins	185	2019	162	.623	101	61	5,732	939	1,547	318	23	307	906	525	81	1,334	28	21	6,389	2,832	648	10	41	21	101	.270	.338	.494	.832
23	Red Sox	184	2016	162	.574	93	69	5,670	878	1,598	343	25	208	836	558	43	1,160	83	24	6,319	2,615	576	8	40	34	137	.282	.348	.461	.810
24	Blue Jays	183	2021	162	.562	91	71	5,476	846	1,455	285	13	262	816	496	51	1,218	81	20	6,068	2,552	560	10	35	14	112	.266	.330	.466	.797
25	Yankees	182	2018	162	.617	100	62	5,515	851	1,374	269	23	267	821	625	62	1,421	63	21	6,271	2,490	559	10	59	21	107	.249	.329	.451	.781