The Chicago Cubs had the highest run differential by a team in 2016, with a differential of 252 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	252	2016	162	.640	103	58	5,503	808	1,409	293	30	199	767	656	96	1,339	66	34	6,334	2,359	522	42	37	45	107	.256	.343	.429	.772
2	Red Sox	184	2016	162	.574	93	69	5,670	878	1,598	343	25	208	836	558	43	1,160	83	24	6,319	2,615	576	8	40	34	137	.282	.348	.461	.810
3	Nationals	151	2016	162	.586	95	67	5,490	763	1,403	268	29	203	735	536	64	1,252	121	39	6,201	2,338	500	48	63	49	102	.256	.326	.426	.751
4	Indians	101	2016	161	.584	94	67	5,484	777	1,435	308	29	185	733	531	49	1,246	134	31	6,155	2,356	522	31	60	16	137	.262	.329	.430	.759
5	Blue Jays	93	2016	162	.549	89	73	5,479	759	1,358	276	18	221	728	632	55	1,362	54	24	6,232	2,333	515	26	40	16	153	.248	.330	.426	.755
6	Dodgers	87	2016	162	.562	91	71	5,518	725	1,376	272	21	189	680	525	58	1,321	45	26	6,163	2,257	482	30	32	31	120	.249	.319	.409	.728
7	Giants	84	2016	162	.537	87	75	5,565	715	1,437	280	54	130	675	572	42	1,107	79	36	6,267	2,215	464	42	46	43	120	.258	.329	.398	.728
8	Cardinals	67	2016	162	.531	86	76	5,548	779	1,415	299	32	225	745	526	70	1,318	35	26	6,222	2,453	556	37	41	28	117	.255	.325	.442	.767
9	Mariners	61	2016	162	.531	86	76	5,583	768	1,446	251	17	223	735	506	72	1,288	56	28	6,226	2,400	491	24	41	29	138	.259	.326	.430	.756
10	Mets	54	2016	162	.537	87	75	5,459	671	1,342	240	19	218	649	517	62	1,302	42	18	6,114	2,274	477	35	41	43	123	.246	.316	.417	.733
11	Tigers	29	2016	161	.534	86	75	5,526	750	1,476	252	30	211	719	493	53	1,303	58	29	6,127	2,421	493	17	38	32	135	.267	.331	.438	.769
12	Orioles	29	2016	162	.549	89	73	5,524	744	1,413	265	6	253	710	468	44	1,324	19	13	6,089	2,449	524	17	36	19	119	.256	.317	.443	.760
13	Astros	23	2016	162	.519	84	78	5,545	724	1,367	291	29	198	689	554	47	1,452	102	44	6,204	2,310	518	27	31	31	134	.247	.319	.417	.735
14	Rangers	8	2016	162	.586	95	67	5,525	765	1,446	257	23	215	746	436	70	1,220	99	36	6,089	2,394	495	18	40	23	114	.262	.322	.433	.755
15	Angels	-10	2016	162	.457	74	88	5,431	717	1,410	279	20	156	686	471	51	991	73	34	6,038	2,197	455	36	49	21	147	.260	.322	.405	.726
16	Rockies	-15	2016	162	.463	75	87	5,614	845	1,544	318	47	204	805	494	40	1,330	66	39	6,236	2,568	569	54	34	35	113	.275	.336	.457	.794
17	Yankees	-22	2016	162	.519	84	78	5,458	680	1,378	245	20	183	647	475	42	1,188	72	22	6,045	2,212	448	21	49	19	121	.252	.315	.405	.720
18	Marlins	-24	2016	161	.491	79	82	5,548	655	1,460	259	42	128	626	447	54	1,213	71	28	6,133	2,187	429	46	38	40	140	.263	.322	.394	.716
19	Pirates	-29	2016	162	.484	78	83	5,542	729	1,426	277	32	153	696	561	81	1,334	110	45	6,261	2,226	462	41	36	39	133	.257	.332	.402	.734
20	White Sox	-29	2016	162	.481	78	84	5,550	686	1,428	277	33	168	656	455	53	1,285	77	36	6,131	2,275	478	29	44	16	122	.257	.317	.410	.727
21	Royals	-37	2016	162	.500	81	81	5,552	675	1,450	264	33	147	640	382	45	1,224	121	35	6,051	2,221	444	38	34	23	134	.261	.312	.400	.712
22	Rays	-41	2016	162	.420	68	94	5,481	672	1,333	288	32	216	647	449	69	1,482	60	37	6,045	2,333	536	18	28	20	88	.243	.307	.426	.733
23	Brewers	-62	2016	162	.451	73	89	5,330	671	1,299	249	19	194	641	599	37	1,543	181	56	6,058	2,168	462	53	39	34	131	.244	.322	.407	.729
24	Padres	-84	2016	162	.420	68	94	5,419	686	1,275	257	26	177	654	449	58	1,500	125	45	5,998	2,115	460	36	36	30	93	.235	.299	.390	.689
25	Athletics	-108	2016	162	.426	69	93	5,500	653	1,352	270	21	169	634	442	33	1,145	50	23	6,022	2,171	460	13	34	19	142	.246	.304	.395	.699