biggest score differential in mlb game since 1900

Since 1900, the Texas Rangers have the highest run differential by a team in a game, with a differential of 27 runs versus the Orioles on August 22, 2007.

Interpreted as:

biggest score differential in MLB regular-season game since 1900

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rangers	27	8/22/2007	TEX	@	BAL	W 30-3	57	30	29	2	0	6	30	8	0	11	0	0	65	49	8	0	0	0	0	.509	.569	.860	1.429
2	Red Sox	25	6/8/1950	BSA	vs	SLA	W 29-4	53	29	28	9	1	7	29	11	0	2	0	0	64	60	17	0		0	0	.528	.609	1.132	1.741
3	Angels	24	6/24/2023	LAA	@	COL	W 25-1	52	25	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
4	Indians	24	7/7/1923	CLE	vs	BSA	W 27-3	43	27	24	5	2	0	25	14	1	1	4	2	61	33	7	3				.558	.672	.767	1.440
5	Blue Jays	23	7/22/2022	TOR	@	BOS	W 28-5	57	28	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
6	White Sox	23	4/23/1955	CWS	@	KCA	W 29-6	54	29	29	5	0	7	28	6	1	4	1	1	63	55	12	0	2	1	0	.537	.571	1.019	1.590
7	Indians	23	8/12/1948	CLE	@	SLA	W 26-3	55	26	29	5	1	4	24	6	0	4	4	0	61	48	10	0			2	.527	.574	.873	1.446
8	Yankees	23	5/24/1936	NYY	@	PHA	W 25-2	45	25	19	3	3	6	25	16	0	5	0	0	61	46	12	0				.422	.574	1.022	1.596
9	Reds	23	6/4/1911	CIN	vs	BSN	W 26-3	44	26	23	4	3	1		11	2	3	6		57	36	8	0				.523	.632	.818	1.450
10	Reds	22	4/20/2025	CIN	@	BAL	W 24-2	51	24	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
11	Indians	22	8/31/2004	CLE	@	NYY	W 22-0	49	22	22	5	1	3	22	9	0	6	1	0	59	38	9	0	1	0	0	.449	.525	.776	1.301
12	Orioles	22	9/28/2000	BAL	vs	TOR	W 23-1	47	23	23	2	0	3	20	5	1	5	0	0	54	34	5	0	1	0	1	.489	.537	.723	1.260
13	Angels	22	8/25/1979	CAL	@	TOR	W 24-2	52	24	26	6	2	5	23	5	0	4	0	0	58	51	13	1	0	0	2	.500	.544	.981	1.525
14	Pirates	22	9/16/1975	PIT	@	CHC	W 22-0	53	22	24	2	1	2	21	6	1	5	0	0	61	34	5	0	1	0	0	.453	.508	.642	1.150
15	Cubs	22	7/3/1945	CHC	@	BSN	W 24-2	53	24	28	7	0	1	22	8	1	0	0	0	62	38	8	0			0	.528	.597	.717	1.314
16	Cardinals	22	7/6/1929	SLN	@	PHN	W 28-6	53	28	28	4	1	2	25	9	1	1	0	0	65	40	7	2				.528	.603	.755	1.358
17	Athletics	22	5/18/1912	PHA	vs	DET	W 24-2	43	24	26	4	6	0	22	7	0	1	10		52	42	10	2				.605	.660	.977	1.637
18	Reds	22	5/13/1902	CIN	vs	PHN	W 24-2	53	24	28	3	3	1	22	5	0	2	2	-9	59	40	7	1		-9	-9	.528	.569	.755	1.324
19	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	21	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
20	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	21	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
21	Dodgers	21	7/10/2021	LAD	vs	ARI	W 22-1	44	22	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
22	Astros	21	8/10/2019	HOU	@	BAL	W 23-2	50	23	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
23	Nationals	21	7/31/2018	WSH	vs	NYM	W 25-4	50	25	26	5	2	5	25	8	1	6	2	0	59	50	12	0	0	1	0	.520	.593	1.000	1.593
24	Phillies	21	7/6/2009	PHI	vs	CIN	W 22-1	43	22	21	6	0	4	21	7	1	9	0	0	52	39	10	0	1	0	1	.488	.558	.907	1.465
25	Royals	21	9/9/2004	KCR	@	DET	W 26-5	52	26	26	5	1	1	25	8	0	6	0	0	62	36	7	0	2	0	0	.500	.548	.692	1.241