Chris Sale is 5-3 with an ERA of 2.76 and 101 strikeouts in 11 appearances against the Astros in his career.
| NAME | DATE | TM | OPP | DEC | GS | CG | GF | SHO | SV | IP | H | TBF | R | ER | HR | BB | IBB | HBP | SO | WP | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Chris Sale | 6/9/2012 |  CWS | vs |  HOU | W | 1 | 0 | 0 | 0 | 0 | 8.0 | 4 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 0 |
| | Chris Sale | 6/14/2013 | CWS | @ |  HOU | L | 1 | 1 | 0 | 0 | 0 | 8.0 | 6 | 32 | 2 | 0 | 0 | 1 | 0 | 0 | 14 | 1 |
| | Chris Sale | 8/28/2013 | CWS | vs | HOU | W | 1 | 0 | 0 | 0 | 0 | 8.0 | 4 | 29 | 1 | 1 | 1 | 2 | 0 | 0 | 12 | 0 |
| | Chris Sale | 6/8/2015 | CWS | vs | HOU | W | 1 | 0 | 0 | 0 | 0 | 8.0 | 5 | 30 | 1 | 1 | 0 | 1 | 0 | 0 | 14 | 0 |
| | Chris Sale | 5/19/2016 | CWS | vs | HOU | W | 1 | 1 | 0 | 0 | 0 | 9.0 | 4 | 31 | 1 | 1 | 1 | 0 | 0 | 0 | 9 | 0 |
| | Chris Sale | 7/2/2016 | CWS | @ | HOU | W | 1 | 0 | 0 | 0 | 0 | 7.0 | 6 | 29 | 5 | 4 | 1 | 1 | 0 | 0 | 9 | 0 |
 | Chris Sale | 6/1/2018 |  BOS | @ | HOU | L | 1 | 0 | 0 | 0 | 0 | 6.0 | 6 | 25 | 4 | 4 | 1 | 1 | 0 | 0 | 6 | 2 |
| | Chris Sale | 5/19/2019 | BOS | vs | HOU | 1 | 0 | 0 | 0 | 0 | 5.1 | 4 | 26 | 3 | 3 | 1 | 5 | 0 | 1 | 10 | 1 | |
| | Chris Sale | 5/24/2019 | BOS | @ | HOU | L | 1 | 0 | 0 | 0 | 0 | 6.0 | 3 | 26 | 4 | 2 | 1 | 2 | 0 | 0 | 5 | 1 |
| | Chris Sale | 8/23/2023 | BOS | @ | HOU | 1 | 0 | 0 | 0 | 0 | 5.0 | 6 | 22 | 4 | 4 | 1 | 1 | 0 | 0 | 9 | 0 | |
| | Chris Sale | 8/28/2023 | BOS | vs | HOU | 1 | 0 | 0 | 0 | 0 | 4.2 | 7 | 23 | 3 | 3 | 1 | 2 | 0 | 0 | 6 | 1 |
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| NL East | W | L | PCT | GB | |
|---|---|---|---|---|---|
| 1 |  Braves | 104 | 58 | .642 | |
| 2 |  Phillies | 90 | 72 | .556 | 14.0 |
| AL East | W | L | PCT | GB | |
| 1 |  Orioles | 101 | 61 | .623 | |
| 2 |  Rays | 99 | 63 | .611 | 2.0 |
| NL West | W | L | PCT | GB | |
| 1 |  Dodgers | 100 | 62 | .617 | |
| 2 |  Diamondbacks | 84 | 78 | .519 | 16.0 |
| NL Central | W | L | PCT | GB | |
| 1 |  Brewers | 92 | 70 | .568 | |
| 2 |  Cubs | 83 | 79 | .512 | 9.0 |
| AL West | W | L | PCT | GB | |
| 1 | Astros | 90 | 72 | .556 | |
| 2 |  Rangers | 90 | 72 | .556 | |
| AL Central | W | L | PCT | GB | |
| 1 |  Twins | 87 | 75 | .537 | |
| 2 |  Tigers | 78 | 84 | .481 | 9.0 |
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