The Pittsburgh Pirates had the most runs by a team in a game in 1975, with 22 runs against the Cubs on September 16, 1975.

Interpreted as:

highest scoring team MLB regular-season game in 1975

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	22	9/16/1975	PIT	@	CHC	W 22-0	53	24	2	1	2	21	6	1	5	0	0	61	34	5	0	1	0	0	.453	.508	.642	1.150
2	Red Sox	20	9/6/1975	BOS	@	MIL	W 20-6	50	24	5	0	3	20	3	0	4	0	0	54	38	8	0	1	0	1	.480	.500	.760	1.260
3	Pirates	18	7/6/1975	PIT	@	CHC	W 18-12	46	20	3	0	4	16	8	1	5	0	0	56	35	7	0	1	3	0	.435	.518	.761	1.279
4	Reds	18	6/13/1975	CIN	@	CHC	W 18-11	50	24	2	0	3	17	7	1	4	1	0	60	35	5	1	1	2	1	.480	.542	.700	1.242
5	Cardinals	17	5/17/1975	STL	@	SFG	W 17-2	46	23	6	2	2	17	5	0	7	0	0	52	39	10	0	1	0	2	.500	.538	.848	1.386
6	Brewers	17	5/1/1975	MIL	vs	DET	W 17-3	37	17	2	2	2	15	7	0	0	1	0	48	29	6	1	3	0	3	.459	.511	.784	1.294
7	Athletics	16	9/20/1975	OAK	@	KCR	W 16-4	46	18	3	0	3	15	6	0	6	2	1	53	30	6	1	0	1	1	.391	.462	.652	1.114
8	Athletics	16	7/22/1975	OAK	@	DET	W 16-4	41	15	0	2	3	16	7	1	5	0	1	49	28	5	0	0	0	1	.366	.469	.683	1.152
9	Rangers	15	8/5/1975	TEX	vs	OAK	W 15-2	40	17	3	0	2	13	5	0	7	1	0	47	26	5	2	0	1	0	.425	.489	.650	1.139
10	Athletics	15	7/8/1975	OAK	vs	CLE	W 15-5	39	14	1	2	2	14	5	0	3	0	0	44	25	5	0	0	0	0	.359	.432	.641	1.073
11	Red Sox	15	6/18/1975	BOS	@	DET	W 15-1	46	20	2	2	3	14	5	0	5	1	0	51	35	7	0	0	0	2	.435	.490	.761	1.251
12	Astros	15	5/31/1975	HOU	@	PHI	W 15-3	40	15	2	0	2	14	4	0	5	0	1	44	23	4	0	0	1	0	.375	.432	.575	1.007
13	Dodgers	14	9/24/1975	LAD	@	SDP	W 14-0	45	18	2	2	3	13	3	0	7	1	0	49	33	7	0	1	0	0	.400	.429	.733	1.162
14	Astros	14	8/23/1975	HOU	@	CHC	W 14-12	45	21	5	1	2	13	4	0	4	3	2	49	34	8	0	0	0	2	.467	.510	.756	1.266
15	Indians	14	8/17/1975	CLE	@	MIN	W 14-5	43	19	1	0	1	13	7	1	6	0	0	51	23	2	0	0	0	3	.442	.529	.535	1.064
16	Yankees	14	7/20/1975	NYY	@	MIN	W 14-2	46	17	2	0	3	13	5	1	3	0	0	53	28	5	1	0	1	1	.370	.442	.609	1.051
17	Phillies	14	7/12/1975	PHI	@	HOU	W 14-2	44	18	3	0	1	14	12	0	5	1	0	56	24	4	0	0	0	1	.409	.536	.545	1.081
18	Angels	14	6/11/1975	CAL	@	DET	W 14-7	38	15	5	0	1	14	8	0	10	3	2	47	23	6	0	1	0	2	.395	.489	.605	1.095
19	Twins	14	5/3/1975	MIN	vs	KCR	W 14-5	36	14	1	0	1	12	6	0	3	0	2	43	18	2	1	0	1	1	.389	.476	.500	.976
20	Mets	14	4/17/1975	NYM	@	STL	W 14-7	43	13	4	0	0	13	9	0	6	0	0	53	17	4	0	1	1	0	.302	.415	.395	.810
21	Rangers	14	4/16/1975	TEX	@	CWS	W 14-4	43	18	6	0	2	13	6	0	7	0	0	51	30	8	1	1	0	1	.419	.480	.698	1.178
22	Astros	14	4/9/1975	HOU	vs	ATL	W 14-2	35	15	3	0	0	14	7	0	2	2	0	44	18	3	2	0	1	1	.429	.524	.514	1.038
23	Athletics	13	9/24/1975	OAK	vs	CWS	W 13-2	38	13	1	1	2	12	5	0	4	0	0	43	22	4	0	0	0	0	.342	.419	.579	.998
24	Phillies	13	9/14/1975	PHI	@	CHC	W 13-7	40	12	0	0	3	12	7	2	8	0	0	49	21	3	0	0	0	0	.300	.429	.525	.954
25	Reds	13	9/3/1975	CIN	vs	LAD	W 13-2	33	9	4	0	0	9	11	2	4	0	0	48	13	4	1	1	0	0	.273	.468	.394	.862