Rocky Colavito has hit the most home runs in a game on Wednesdays, with 4 homers against the Orioles on June 10, 1959.
| NAME | HR | DATE | TM | OPP | AB | R | H | 2B | 3B | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Colavito | 4 | 6/10/1959 |  CLE | @ |  BAL | 4 | 5 | 4 | 0 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 5 | 16 | 4 | 0 | 0 | 0 | 0 |
| 2 | | E. Sosa | 3 | 9/24/2025 |  PHI | vs |  MIA | 4 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 1 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 3 | | I. Herrera | 3 | 4/2/2025 |  STL | vs |  LAA | 4 | 3 | 3 | 0 | 0 | 6 | 1 | 0 | 1 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 4 |  | Y. Alvarez | 3 | 8/28/2024 |  HOU | @ | PHI | 4 | 3 | 4 | 0 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 5 | 13 | 3 | 0 | 0 | 0 | 0 |
| 5 |  | K. Schwarber | 3 | 8/7/2024 | PHI | @ |  LAD | 4 | 3 | 4 | 1 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 5 | 14 | 4 | 0 | 0 | 0 | 0 |
| 6 |  | A. Judge | 3 | 8/23/2023 |  NYY | vs |  WSH | 4 | 3 | 3 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 7 |  | B. Reynolds | 3 | 6/29/2022 |  PIT | @ | WSH | 5 | 3 | 3 | 0 | 0 | 6 | 0 | 0 | 1 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 8 | | B. Rodgers | 3 | 6/1/2022 |  COL | vs | MIA | 5 | 4 | 3 | 0 | 0 | 4 | 1 | 0 | 1 | 0 | 0 | 6 | 12 | 3 | 0 | 0 | 0 | 0 |
| 9 |  | V. Guerrero Jr. | 3 | 4/13/2022 |  TOR | @ | NYY | 4 | 3 | 4 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 14 | 4 | 0 | 0 | 0 | 0 |
| 10 | | K. Higashioka | 3 | 9/16/2020 | NYY | vs | TOR | 4 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 11 | | A. Duvall | 3 | 9/9/2020 |  ATL | vs | MIA | 4 | 5 | 3 | 0 | 0 | 9 | 2 | 0 | 1 | 0 | 0 | 6 | 12 | 3 | 0 | 0 | 0 | 0 |
| 12 | | A. Duvall | 3 | 9/2/2020 | ATL | @ |  BOS | 4 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 13 | | P. DeJong | 3 | 7/24/2019 | STL | @ | PIT | 4 | 4 | 4 | 1 | 0 | 5 | 0 | 1 | 0 | 0 | 0 | 5 | 14 | 4 | 0 | 0 | 0 | 0 |
| 14 |  | T. Story | 3 | 9/5/2018 | COL | vs |  SFG | 4 | 3 | 3 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 15 |  | M. Betts | 3 | 5/2/2018 | BOS | vs |  KCR | 4 | 3 | 4 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 13 | 3 | 0 | 0 | 0 | 0 |
| 16 |  | E. Encarnacion | 3 | 5/2/2018 | CLE | vs |  TEX | 5 | 3 | 3 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 17 | | H. Renfroe | 3 | 9/20/2017 |  SDP | vs |  ARI | 5 | 3 | 3 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 18 |  | N. Arenado | 3 | 7/19/2017 | COL | vs | SDP | 6 | 4 | 5 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 6 | 14 | 3 | 0 | 0 | 0 | 0 |
| 19 | | H. Ramirez | 3 | 7/20/2016 | BOS | vs | SFG | 4 | 3 | 3 | 0 | 0 | 6 | 0 | 1 | 0 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 20 | | L. Duda | 3 | 7/29/2015 |  NYM | vs | SDP | 3 | 3 | 3 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 21 |  | B. Harper | 3 | 5/6/2015 | WSH | vs |  MIA | 4 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 22 | | A. Gonzalez | 3 | 4/8/2015 | LAD | vs | SDP | 4 | 3 | 4 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 13 | 3 | 0 | 0 | 0 | 0 |
| 23 | | P. Sandoval | 3 | 9/4/2013 | SFG | @ | SDP | 5 | 3 | 4 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 5 | 13 | 3 | 0 | 0 | 0 | 0 |
| 24 | | C. Gonzalez | 3 | 6/5/2013 | COL | @ |  CIN | 5 | 3 | 3 | 0 | 0 | 6 | 0 | 0 | 1 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 25 |  | R. Zimmerman | 3 | 5/29/2013 | WSH | @ | BAL | 4 | 3 | 3 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for home runs going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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