Between the 1946 and 2022 seasons, the New York Yankees had the highest run differential by a team, with a differential of 8,200 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	8,200	12,121	.572	6,924	5,178	414,119	58,405	109,122	18,591	2,457	12,955	55,273	43,863	3,197	67,544	6,229	2,734	468,045	171,492	34,003	3,693	3,173	2,778	9,605	.264	.336	.414	.750
2	Dodgers	6,231	12,140	.556	6,735	5,388	412,242	53,630	106,509	17,735	2,584	10,925	50,309	41,259	2,874	70,858	8,086	3,493	465,371	162,187	31,244	6,072	2,924	3,664	8,960	.258	.328	.393	.721
3	Red Sox	4,239	12,127	.534	6,473	5,642	417,701	58,999	112,114	21,841	2,497	12,110	55,818	44,572	3,123	69,382	4,771	2,469	472,258	175,279	36,448	3,608	3,254	2,942	10,466	.268	.341	.420	.761
4	Cardinals	3,340	12,128	.532	6,436	5,668	414,309	53,918	109,059	19,449	3,105	9,547	50,568	39,743	3,027	68,245	7,904	3,547	465,188	163,359	32,101	5,066	3,043	3,740	9,211	.263	.330	.394	.724
5	Braves	3,054	12,124	.526	6,359	5,739	412,626	53,753	106,496	18,489	2,336	11,776	50,676	40,263	2,759	70,689	5,940	3,011	464,002	164,985	32,601	5,566	2,788	3,620	9,349	.258	.326	.400	.726
6	Giants	1,882	12,133	.517	6,267	5,855	412,783	53,344	105,548	18,077	2,873	11,360	50,053	40,604	2,978	71,642	6,218	3,096	464,675	163,451	32,310	5,393	2,917	3,980	9,006	.256	.325	.396	.721
7	Guardians	1,226	12,117	.510	6,169	5,930	413,454	54,726	107,679	18,845	2,293	11,495	51,635	40,904	3,146	68,761	6,617	3,294	465,095	165,595	32,633	4,342	3,249	2,469	9,498	.260	.329	.401	.730
8	Astros	486	9,656	.501	4,831	4,820	327,589	40,999	83,458	15,295	2,129	7,969	38,558	31,207	2,741	60,139	6,925	3,067	368,149	126,918	25,393	3,996	2,616	3,094	7,116	.255	.322	.387	.710
9	White Sox	482	12,134	.503	6,092	6,014	412,420	53,327	106,895	18,048	2,674	10,499	50,246	39,549	3,536	67,056	7,130	3,420	463,329	161,788	31,221	4,670	3,154	2,433	9,451	.259	.327	.392	.719
10	Blue Jays	383	7,228	.498	3,598	3,627	247,803	33,522	64,585	12,878	1,445	7,872	31,793	22,930	2,260	46,089	4,373	1,904	276,499	103,969	22,195	1,473	2,033	1,361	5,638	.261	.326	.420	.746
11	Reds	135	12,125	.505	6,112	5,997	413,195	53,733	106,460	19,393	2,501	11,518	50,561	40,069	3,094	74,640	7,898	3,298	464,498	165,409	33,412	5,184	2,956	3,627	8,725	.258	.326	.400	.726
12	Diamondbacks	-368	3,948	.485	1,914	2,034	134,813	17,873	34,333	7,072	976	4,168	17,029	13,070	1,259	29,743	2,180	835	151,458	55,861	12,216	1,247	1,069	1,056	2,816	.255	.324	.414	.738
13	Angels	-406	9,815	.498	4,885	4,927	333,193	42,510	85,501	14,747	1,764	8,753	39,984	31,201	2,639	59,342	5,820	3,012	373,226	130,035	25,264	3,514	2,679	2,447	7,615	.257	.323	.390	.713
14	Rays	-610	3,946	.485	1,912	2,034	134,301	17,522	34,187	6,827	800	4,075	16,670	12,812	1,490	30,108	2,811	1,119	150,395	54,839	11,702	721	1,071	663	2,796	.255	.324	.408	.732
15	Mets	-888	9,648	.483	4,652	4,988	326,536	39,641	81,680	14,550	1,770	8,104	37,293	31,197	2,633	61,877	5,627	2,692	366,851	124,082	24,424	3,957	2,528	3,109	7,208	.250	.318	.380	.698
16	Brewers	-1,031	8,518	.484	4,123	4,391	289,317	37,800	74,244	13,832	1,702	8,323	35,809	27,690	2,586	55,656	5,576	2,647	325,053	116,449	23,857	3,129	2,331	2,118	6,344	.257	.325	.402	.727
17	Tigers	-1,080	12,138	.493	5,969	6,146	414,232	54,614	107,366	18,359	2,877	11,841	51,585	41,482	2,894	70,926	5,308	2,886	465,633	167,002	33,077	4,003	3,022	2,421	9,588	.259	.329	.403	.732
18	Phillies	-1,176	12,129	.492	5,965	6,147	412,655	52,088	105,259	18,890	3,075	10,369	48,904	40,529	3,091	74,675	6,782	2,849	464,155	161,406	32,334	4,959	2,921	3,690	8,748	.255	.324	.391	.715
19	Nationals	-1,180	8,514	.484	4,123	4,387	288,047	35,660	73,165	14,091	1,738	7,269	33,506	27,235	2,453	54,431	6,150	2,659	323,756	112,539	23,098	3,824	2,197	2,863	6,247	.254	.321	.391	.712
20	Rockies	-1,265	4,696	.469	2,201	2,495	161,520	23,508	43,989	8,630	1,239	5,344	22,342	14,950	1,455	34,092	2,872	1,301	181,154	71,129	15,213	1,968	1,261	1,176	3,581	.272	.337	.440	.777
21	Athletics	-1,394	12,133	.489	5,927	6,189	410,747	53,216	103,486	18,225	2,388	10,964	49,996	42,765	3,108	71,576	7,200	3,143	463,755	159,379	31,577	4,115	3,020	2,244	9,445	.252	.325	.388	.713
22	Orioles	-1,761	12,113	.490	5,931	6,164	412,199	52,616	105,327	18,573	2,078	11,661	49,702	40,931	2,986	70,210	5,543	2,723	463,202	163,039	32,312	4,089	2,997	2,544	9,867	.256	.325	.396	.721
23	Mariners	-1,827	7,227	.474	3,426	3,799	246,759	32,084	63,689	11,847	1,231	7,270	30,469	23,268	2,099	46,085	4,718	2,097	276,041	99,808	20,348	1,921	1,994	1,634	5,451	.258	.325	.404	.729
24	Marlins	-1,898	4,688	.460	2,157	2,531	159,338	19,789	40,641	7,756	930	4,248	18,752	14,575	1,716	35,193	3,001	1,214	178,477	63,001	12,934	1,662	1,186	1,159	3,497	.255	.322	.395	.717
25	Royals	-2,065	8,509	.478	4,066	4,441	291,318	37,262	76,713	14,309	2,202	6,639	35,129	25,037	2,320	49,231	6,753	2,802	323,538	115,343	23,150	2,322	2,541	1,826	6,566	.263	.324	.396	.720