Between the 1998 and 2022 seasons, the New York Yankees had the highest run differential by a team, with a differential of 3,166 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	3,166	3,946	.589	2,322	1,622	135,241	20,441	35,916	6,783	525	5,305	19,550	14,739	1,588	28,111	2,479	824	153,310	59,664	12,613	623	1,119	798	3,220	.266	.342	.441	.783
2	Red Sox	2,286	3,947	.550	2,172	1,775	137,168	20,317	37,186	8,235	665	4,650	19,348	14,064	1,421	28,094	1,931	696	154,409	60,701	13,550	537	1,219	966	3,201	.271	.342	.443	.785
3	Dodgers	2,243	3,948	.557	2,201	1,747	134,067	17,979	34,542	6,652	687	4,261	17,121	13,348	1,422	28,088	2,374	921	151,278	55,351	11,600	1,416	1,025	1,064	2,954	.258	.329	.413	.742
4	Cardinals	1,970	3,945	.553	2,183	1,761	134,240	18,751	35,333	6,949	617	4,385	17,841	13,338	1,566	27,708	1,965	844	151,745	56,671	11,951	1,500	1,101	1,187	3,092	.263	.334	.422	.757
5	Braves	1,879	3,945	.550	2,168	1,776	134,607	18,374	35,050	7,041	612	4,364	17,529	13,302	1,282	28,935	2,002	839	151,683	56,407	12,017	1,486	1,006	1,119	3,029	.260	.330	.419	.750
6	Athletics	1,146	3,946	.525	2,072	1,874	134,478	18,424	33,874	7,031	566	4,343	17,525	14,089	1,408	28,144	1,828	638	151,636	55,066	11,940	576	1,085	637	3,125	.252	.327	.409	.736
7	Astros	1,072	3,948	.519	2,050	1,897	134,289	18,338	34,808	7,024	633	4,470	17,475	13,097	1,483	28,511	2,383	972	151,197	56,508	12,127	1,247	1,081	877	3,158	.259	.329	.421	.750
8	Guardians	1,067	3,946	.523	2,064	1,882	135,011	18,996	35,343	7,353	642	4,384	18,113	13,627	1,502	28,402	2,374	887	152,192	57,132	12,379	870	1,182	766	3,037	.262	.334	.423	.757
9	Giants	710	3,947	.524	2,068	1,878	134,610	17,633	34,795	6,987	842	3,833	16,768	13,024	1,246	27,341	1,853	817	151,449	54,965	11,662	1,445	1,124	1,293	3,110	.258	.327	.408	.735
10	Angels	524	3,948	.520	2,053	1,895	135,026	18,312	35,419	6,788	657	4,157	17,420	12,032	1,337	26,440	2,615	1,057	150,383	55,992	11,602	883	1,105	893	3,070	.262	.326	.415	.741
11	Blue Jays	496	3,948	.503	1,986	1,961	135,385	18,952	35,217	7,406	561	4,921	18,119	12,753	1,432	28,088	2,037	789	151,245	58,508	12,888	600	1,075	621	3,142	.260	.328	.432	.760
12	Mets	256	3,947	.506	1,997	1,950	133,979	17,376	34,116	6,765	647	4,044	16,565	13,145	1,462	28,315	2,335	874	151,005	54,307	11,456	1,405	1,014	1,125	2,995	.255	.326	.405	.731
13	Cubs	46	3,948	.497	1,960	1,987	134,347	17,760	34,221	6,852	715	4,463	16,906	12,961	1,486	30,468	1,803	849	151,159	55,892	12,030	1,419	946	1,003	2,989	.255	.325	.416	.741
14	Phillies	6	3,947	.503	1,986	1,961	135,003	18,094	34,500	6,919	814	4,268	17,230	13,451	1,440	29,527	2,463	704	152,197	55,851	12,001	1,303	1,000	1,162	2,757	.256	.327	.414	.741
15	White Sox	-259	3,949	.498	1,964	1,983	134,778	18,341	35,189	6,637	611	4,648	17,552	11,724	1,493	27,795	2,249	1,015	149,956	56,992	11,896	911	1,050	575	3,091	.261	.325	.423	.748
16	Rangers	-304	3,949	.494	1,952	1,997	135,944	19,588	35,980	7,098	683	4,913	18,644	12,417	1,398	28,691	2,405	918	151,682	59,183	12,694	785	1,138	710	2,935	.265	.330	.435	.765
17	Diamondbacks	-368	3,948	.485	1,914	2,034	134,813	17,873	34,333	7,072	976	4,168	17,029	13,070	1,259	29,743	2,180	835	151,458	55,861	12,216	1,247	1,069	1,056	2,816	.255	.324	.414	.738
18	Mariners	-385	3,947	.496	1,957	1,990	134,958	17,615	34,575	6,520	599	4,186	16,770	12,473	1,329	28,527	2,485	936	150,634	54,851	11,305	820	1,054	797	2,864	.256	.323	.406	.729
19	Twins	-406	3,948	.494	1,948	1,999	135,600	18,175	35,525	7,140	776	3,878	17,223	12,569	1,257	27,607	2,140	926	151,262	55,851	11,794	710	1,126	782	3,159	.262	.328	.412	.740
20	Rays	-610	3,946	.485	1,912	2,034	134,301	17,522	34,187	6,827	800	4,075	16,670	12,812	1,490	30,108	2,811	1,119	150,395	54,839	11,702	721	1,071	663	2,796	.255	.324	.408	.732
21	Brewers	-683	3,948	.487	1,923	2,024	133,706	17,597	33,807	6,822	665	4,534	16,817	13,010	1,654	31,236	2,441	913	150,670	55,561	12,021	1,345	955	962	2,990	.253	.325	.416	.740
22	Nationals	-880	3,946	.474	1,869	2,077	133,445	17,161	34,138	6,976	688	3,964	16,313	12,656	1,379	28,671	2,233	938	150,044	54,382	11,628	1,567	997	1,081	3,044	.256	.324	.408	.732
23	Rockies	-1,005	3,949	.465	1,838	2,111	135,810	19,508	36,760	7,321	1,021	4,417	18,571	12,611	1,185	29,276	2,172	968	152,273	59,374	12,759	1,612	1,055	981	2,986	.271	.336	.437	.773
24	Reds	-1,011	3,951	.475	1,875	2,074	134,205	17,727	34,064	6,763	595	4,502	16,931	13,108	1,583	30,410	2,348	945	151,377	55,523	11,860	1,499	982	988	2,859	.254	.325	.414	.739
25	Padres	-1,060	3,949	.477	1,885	2,064	133,245	16,599	32,949	6,416	737	3,720	15,778	13,205	1,197	30,391	2,440	916	149,900	51,999	10,873	1,217	1,036	888	2,835	.247	.318	.390	.709