The Boston Red Sox had the highest run differential by a team in 2007, with a differential of 210 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	210	2007	162	.593	96	66	5,589	867	1,561	352	35	166	829	689	64	1,042	96	24	6,426	2,481	553	30	54	54	146	.279	.362	.444	.806
2	Yankees	191	2007	162	.580	94	68	5,717	968	1,656	326	32	201	929	637	78	991	123	40	6,527	2,649	559	41	54	32	138	.290	.366	.463	.829
3	Indians	107	2007	162	.593	96	66	5,604	811	1,504	305	27	178	784	590	80	1,202	72	41	6,365	2,397	510	32	59	56	114	.268	.343	.428	.771
4	Rockies	102	2007	163	.552	90	73	5,691	860	1,591	313	36	171	823	622	58	1,152	100	31	6,498	2,489	520	83	44	51	140	.280	.354	.437	.791
5	Angels	91	2007	162	.580	94	68	5,554	822	1,578	324	23	123	776	507	40	883	139	55	6,198	2,317	470	32	65	55	146	.284	.345	.417	.762
6	Tigers	90	2007	162	.543	88	74	5,757	887	1,652	352	50	177	857	474	56	1,054	103	30	6,363	2,635	579	31	45	45	128	.287	.345	.458	.802
7	Braves	77	2007	162	.519	84	78	5,689	810	1,562	328	27	176	781	534	49	1,149	64	30	6,374	2,472	531	55	47	43	137	.275	.339	.435	.774
8	Padres	75	2007	163	.546	89	74	5,612	741	1,408	322	31	171	704	557	49	1,229	55	24	6,326	2,305	524	64	44	45	113	.251	.322	.411	.732
9	Phillies	71	2007	162	.549	89	73	5,688	892	1,558	326	41	213	850	641	90	1,205	138	19	6,536	2,605	580	65	52	74	125	.274	.354	.458	.812
10	Cubs	62	2007	162	.525	85	77	5,643	752	1,530	340	28	151	711	500	40	1,054	86	33	6,268	2,379	519	48	37	48	127	.271	.333	.422	.754
11	Mets	54	2007	162	.543	88	74	5,605	804	1,543	294	27	177	761	549	54	981	200	46	6,343	2,422	498	77	58	64	114	.275	.342	.432	.775
12	Blue Jays	54	2007	162	.512	83	79	5,536	753	1,434	344	24	165	719	533	47	1,044	57	22	6,197	2,321	533	33	48	32	127	.259	.327	.419	.746
13	Brewers	25	2007	162	.512	83	79	5,554	801	1,455	310	37	231	774	501	76	1,137	96	32	6,238	2,532	578	60	47	60	112	.262	.329	.456	.785
14	Dodgers	8	2007	162	.506	82	80	5,614	735	1,544	276	35	129	706	511	41	864	137	50	6,279	2,277	440	58	55	41	116	.275	.337	.406	.743
15	Twins	-7	2007	162	.488	79	83	5,522	718	1,460	273	36	118	671	512	48	839	112	30	6,161	2,159	427	34	45	41	149	.264	.330	.391	.721
16	Athletics	-17	2007	162	.469	76	86	5,577	741	1,430	295	16	171	711	664	49	1,119	52	20	6,364	2,270	482	18	56	29	142	.256	.338	.407	.745
17	Mariners	-19	2007	162	.543	88	74	5,684	794	1,629	284	22	153	754	389	62	861	81	30	6,208	2,416	459	33	40	32	154	.287	.337	.425	.762
18	Diamondbacks	-20	2007	162	.556	90	72	5,398	712	1,350	286	40	171	687	532	57	1,111	109	24	6,100	2,229	497	55	58	38	121	.250	.321	.413	.734
19	Rangers	-28	2007	162	.463	75	87	5,555	816	1,460	298	36	179	768	503	56	1,224	88	25	6,213	2,367	513	57	42	27	129	.263	.328	.426	.754
20	Giants	-37	2007	162	.438	71	91	5,538	683	1,407	267	37	131	641	532	39	907	119	33	6,212	2,141	435	67	36	74	142	.254	.322	.387	.708
21	Reds	-70	2007	162	.444	72	90	5,607	783	1,496	293	23	204	747	536	66	1,113	97	31	6,328	2,447	520	73	46	51	140	.267	.335	.436	.772
22	Royals	-72	2007	162	.426	69	93	5,534	706	1,447	300	46	102	660	428	89	1,069	78	44	6,139	2,145	448	41	47	34	151	.261	.322	.388	.710
23	Astros	-90	2007	162	.451	73	89	5,605	723	1,457	293	30	167	700	547	55	1,043	65	33	6,324	2,311	490	77	40	40	142	.260	.330	.412	.742
24	Marlins	-101	2007	162	.438	71	91	5,627	790	1,504	340	38	201	749	521	82	1,332	105	34	6,344	2,523	579	72	42	46	107	.267	.336	.448	.784
25	Cardinals	-104	2007	162	.481	78	84	5,529	725	1,513	279	13	141	690	506	54	909	56	33	6,211	2,241	433	68	54	47	154	.274	.337	.405	.743