The Chicago Cubs, the San Diego Padres and the New York Yankees were tied for the most runs in a game in April 2016, with 16 runs.

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	16	4/21/2016	CHC	@	CIN	W 16-0	46	18	3	0	5	15	6	0	7	0	0	52	36	8	0	0	0	0	.391	.462	.783	1.244
2	Padres	16	4/9/2016	SDP	@	COL	W 16-3	44	19	2	0	4	16	6	0	8	0	1	50	33	6	0	0	0	2	.432	.500	.750	1.250
3	Yankees	16	4/6/2016	NYY	vs	HOU	W 16-6	41	17	2	1	3	16	7	0	7	2	0	48	30	6	0	0	0	0	.415	.500	.732	1.232
4	Dodgers	15	4/4/2016	LAD	@	SDP	W 15-0	42	17	7	1	0	13	4	2	10	0	0	49	26	8	0	1	0	0	.405	.469	.619	1.088
5	Cardinals	14	4/15/2016	STL	vs	CIN	W 14-3	39	13	2	0	6	14	4	1	5	0	0	44	33	8	0	0	0	1	.333	.409	.846	1.255
6	Cubs	14	4/7/2016	CHC	@	ARI	W 14-6	41	14	3	2	1	11	10	1	5	1	0	52	24	6	0	0	0	0	.341	.481	.585	1.066
7	Mets	13	4/29/2016	NYM	vs	SFG	W 13-1	36	12	3	0	1	13	6	0	7	0	0	42	18	4	0	0	0	0	.333	.429	.500	.929
8	Giants	13	4/27/2016	SFG	vs	SDP	W 13-9	38	16	2	3	0	13	7	0	3	0	0	47	24	5	0	2	0	1	.421	.489	.632	1.121
9	Reds	13	4/23/2016	CIN	vs	CHC	W 13-5	36	15	3	0	4	11	4	0	9	0	0	40	30	7	0	0	1	0	.417	.475	.833	1.308
10	Padres	13	4/8/2016	SDP	@	COL	W 13-6	44	18	3	1	2	13	5	2	7	3	0	51	29	6	0	0	0	1	.409	.490	.659	1.149
11	Diamondbacks	12	4/25/2016	ARI	vs	STL	W 12-7	40	18	6	1	1	11	6	0	4	0	1	46	29	8	0	0	0	2	.450	.522	.725	1.247
12	Dodgers	12	4/24/2016	LAD	@	COL	W 12-10	37	11	4	1	1	11	10	0	6	0	0	48	20	6	1	0	0	1	.297	.447	.541	.987
13	Pirates	12	4/24/2016	PIT	@	ARI	W 12-10	55	20	7	1	0	11	8	0	17	0	0	64	29	8	1	0	1	2	.364	.444	.527	.972
14	Rays	12	4/21/2016	TBR	@	BOS	W 12-8	40	15	5	0	2	11	6	4	8	0	0	51	26	7	1	0	0	0	.375	.500	.650	1.150
15	Cardinals	12	4/10/2016	STL	@	ATL	W 12-7	36	10	2	0	2	12	9	3	10	2	0	49	18	4	1	0	1	0	.278	.458	.500	.958
16	Cardinals	12	4/9/2016	STL	@	ATL	W 12-2	42	14	2	1	0	9	9	0	9	1	0	53	18	3	0	2	1	1	.333	.434	.429	.863
17	Giants	12	4/7/2016	SFG	vs	LAD	W 12-6	39	17	2	1	1	12	3	0	6	0	0	43	24	4	1	0	0	1	.436	.476	.615	1.092
18	Giants	12	4/4/2016	SFG	@	MIL	W 12-3	40	15	3	0	4	12	5	0	3	1	0	46	30	7	0	1	0	1	.375	.435	.750	1.185
19	Cardinals	11	4/27/2016	STL	@	ARI	W 11-4	41	14	2	1	1	11	7	0	7	1	0	48	21	4	0	0	0	1	.341	.438	.512	.950
20	Red Sox	11	4/26/2016	BOS	@	ATL	W 11-4	39	13	7	1	1	10	3	1	5	3	0	43	25	9	0	0	1	0	.333	.395	.641	1.036
21	Mariners	11	4/26/2016	SEA	vs	HOU	W 11-1	37	13	2	0	1	10	2	0	8	0	0	39	18	3	0	0	0	0	.351	.385	.486	.871
22	Cardinals	11	4/23/2016	STL	@	SDP	W 11-2	40	16	3	0	3	11	5	0	4	0	1	45	28	6	0	0	0	2	.400	.467	.700	1.167
23	Pirates	11	4/21/2016	PIT	@	SDP	W 11-1	38	11	4	0	0	10	5	2	7	2	0	45	15	4	0	0	1	1	.289	.400	.395	.795
24	Mets	11	4/19/2016	NYM	@	PHI	W 11-1	40	12	3	0	6	11	3	1	7	0	0	44	33	9	0	0	0	0	.300	.364	.825	1.189
25	Orioles	11	4/15/2016	BAL	@	TEX	W 11-5	37	13	2	0	5	11	3	0	6	0	0	40	30	7	0	0	0	3	.351	.400	.811	1.211