The Toronto Blue Jays had the most runs by an AL team in a game with >0 games played in 2021, with 22 runs against the Orioles on September 12, 2021.

Interpreted as:

MLB team most runs in a regular-season game 2021 al

	TEAM	R	G	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Blue Jays	22	1	9/12/2021	TOR	@	BAL	W 22-7	45	19	5	0	5	22	8	2	8	0	0	55	39	10	0	0	0	0	.422	.527	.867	1.394
2	Red Sox	20	1	8/11/2021	BOS	vs	TBR	W 20-8	42	19	7	2	1	20	9	2	6	0	0	53	33	10	0	0	2	1	.452	.566	.786	1.352
3	Blue Jays	18	1	6/13/2021	TOR	@	BOS	W 18-4	44	20	3	0	8	18	4	0	7	1	0	49	47	11	0	1	0	3	.455	.490	1.068	1.558
4	Orioles	18	1	6/6/2021	BAL	vs	CLE	W 18-5	43	21	3	0	2	16	3	1	6	0	0	47	30	5	0	0	0	2	.488	.532	.698	1.230
5	White Sox	17	1	8/27/2021	CWS	vs	CHC	W 17-13	41	15	5	0	2	16	9	2	2	0	0	52	26	7	0	0	0	0	.366	.500	.634	1.134
6	Athletics	17	1	8/12/2021	OAK	@	CLE	W 17-0	40	14	3	0	2	17	10	3	4	0	0	54	23	5	0	1	0	1	.350	.500	.575	1.075
7	Tigers	17	1	7/28/2021	DET	@	MIN	W 17-14	39	16	6	1	0	17	9	0	6	0	1	51	24	7	0	3	0	0	.410	.490	.615	1.106
8	Red Sox	16	1	8/14/2021	BOS	vs	BAL	W 16-2	38	17	3	1	5	15	4	2	3	0	1	44	37	9	0	0	0	2	.447	.523	.974	1.496
9	White Sox	16	1	5/17/2021	CWS	@	MIN	W 16-4	40	18	5	1	3	16	8	0	4	0	0	50	34	9	0	2	0	1	.450	.520	.850	1.370
10	Astros	16	1	4/24/2021	HOU	vs	LAA	W 16-2	42	18	7	1	3	14	5	1	7	0	0	48	36	11	0	0	1	2	.429	.500	.857	1.357
11	Astros	15	1	9/13/2021	HOU	@	TEX	W 15-1	42	16	3	0	5	15	5	1	8	0	0	48	34	8	0	0	0	1	.381	.458	.810	1.268
12	Tigers	15	1	9/3/2021	DET	@	CIN	W 15-5	45	18	5	0	5	14	3	0	9	0	1	48	38	10	0	0	0	0	.400	.438	.844	1.282
13	Astros	15	1	8/21/2021	HOU	vs	SEA	W 15-1	38	15	5	2	2	14	3	0	5	0	0	42	30	9	0	1	0	0	.395	.429	.789	1.218
14	Red Sox	15	1	7/1/2021	BOS	vs	KCR	W 15-1	38	17	3	0	4	14	4	2	9	0	0	45	32	7	0	1	0	2	.447	.511	.842	1.353
15	White Sox	15	1	6/12/2021	CWS	@	DET	W 15-2	40	13	5	0	1	14	11	1	7	0	0	52	21	6	0	0	0	1	.325	.481	.525	1.006
16	Blue Jays	15	1	4/10/2021	TOR	vs	LAA	W 15-1	39	14	4	0	0	14	9	0	6	1	0	48	18	4	0	0	0	1	.359	.479	.462	.941
17	Twins	15	1	4/5/2021	MIN	@	DET	W 15-6	40	14	5	0	2	14	11	0	13	0	0	51	25	7	0	0	0	0	.350	.490	.625	1.115
18	Angels	14	1	9/25/2021	LAA	vs	SEA	W 14-1	37	14	1	2	1	14	8	1	8	0	0	46	22	4	0	0	0	1	.378	.500	.595	1.095
19	Athletics	14	1	9/24/2021	OAK	vs	HOU	W 14-2	35	14	2	0	1	14	6	0	11	0	2	42	19	3	0	1	0	0	.400	.476	.543	1.019
20	Angels	14	1	8/24/2021	LAA	@	BAL	W 14-8	47	19	2	1	1	14	4	1	10	0	0	52	26	4	0	0	1	1	.404	.462	.553	1.015
21	Rays	14	1	7/29/2021	TBR	vs	NYY	W 14-0	36	12	2	0	4	13	4	0	14	0	0	41	26	6	0	1	0	0	.333	.390	.722	1.112
22	Twins	14	1	7/28/2021	MIN	vs	DET	L 14-17	43	16	1	0	7	14	7	1	8	0	0	51	38	8	0	0	0	0	.372	.471	.884	1.354
23	Tigers	14	1	7/19/2021	DET	vs	TEX	W 14-0	39	19	3	0	1	14	6	1	4	0	0	47	25	4	0	1	0	1	.487	.553	.641	1.194
24	Indians	14	1	7/10/2021	CLE	vs	KCR	W 14-6	38	17	4	0	4	13	2	1	7	2	0	41	33	8	0	0	0	2	.447	.488	.868	1.356
25	Astros	14	1	6/13/2021	HOU	@	MIN	W 14-3	43	20	7	0	3	14	4	0	6	2	0	51	36	10	0	4	0	0	.465	.471	.837	1.308