Mike Trout has scored the most career runs against the Mariners, with 149 runs.

Interpreted as:

most careerhome runs by a player against mariners

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mike Trout M. Trout	149	197	706	220	38	11	56	138	126	11	198	15	6	854	448	105	0	11	31	7	.312	.418	.635	1.053
2	Rickey Henderson R. Henderson	145	177	647	182	35	5	16	80	131	4	117	93	16	788	275	56	2	4	5	7	.281	.403	.425	.828
3	Rafael Palmeiro R. Palmeiro	140	216	793	230	43	3	52	143	105	7	114	6	1	917	435	98	2	10	17	21	.290	.374	.549	.922
4	Wade Boggs W. Boggs	132	184	691	236	51	4	7	83	115	2	66	2	2	819	316	62	3	8	16	26	.342	.433	.457	.890
5	Paul Molitor P. Molitor	126	181	702	223	38	4	17	100	93	4	93	45	7	815	320	59	5	11	7	7	.318	.395	.456	.851
6	Cal Ripken Jr. C. Ripken Jr.	125	229	882	261	50	2	32	124	88	3	97	1	4	983	411	84	0	10	9	26	.296	.358	.466	.824
7	Robin Yount R. Yount	125	186	745	212	42	7	23	110	71	7	96	23	5	831	337	72	2	6	8	8	.285	.350	.452	.802
8	Ian Kinsler I. Kinsler	119	166	651	168	40	0	23	62	71	10	90	25	5	738	277	63	4	2	1	17	.258	.339	.425	.765
9	Jose Altuve J. Altuve	118	190	775	242	48	3	21	96	68	6	112	34	5	857	359	72	1	7	14	13	.312	.369	.463	.832
10	Elvis Andrus E. Andrus	115	222	842	213	48	4	15	82	53	7	138	23	9	922	314	67	14	6	0	18	.253	.301	.373	.674
11	Michael Young M. Young	115	212	855	259	45	5	18	108	58	3	125	11	3	926	368	68	2	8	3	24	.303	.346	.430	.777
12	Tony Phillips T. Phillips	112	164	579	157	26	3	15	66	96	6	102	9	12	689	234	44	5	3	4	10	.271	.379	.404	.783
13	Lou Whitaker L. Whitaker	107	165	552	148	35	3	17	67	94	1	71	9	6	658	240	55	8	3	7	9	.268	.374	.435	.809
14	Garret Anderson G. Anderson	104	206	819	226	56	2	24	119	39	0	122	6	5	869	358	82	2	9	12	13	.276	.306	.437	.743
15	Alan Trammell A. Trammell	103	168	599	168	33	5	16	70	77	1	71	22	10	689	259	54	8	4	3	15	.280	.361	.432	.794
16	Derek Jeter D. Jeter	102	169	685	196	32	1	19	79	57	11	101	18	5	762	287	52	5	4	2	15	.286	.349	.419	.768
17	Frank Thomas F. Thomas	102	173	601	168	27	2	36	119	132	6	116	1	1	745	307	65	0	6	12	27	.280	.411	.511	.922
18	Johnny Damon J. Damon	101	149	560	158	29	6	13	57	63	2	59	17	8	633	238	48	5	3	1	6	.282	.355	.425	.780
19	George Brett G. Brett	101	170	636	209	47	11	21	117	74	2	59	12	2	721	341	79	0	9	15	12	.329	.395	.536	.931
20	Harold Baines H. Baines	100	213	737	213	39	5	29	132	82	0	113	2	5	832	349	73	1	12	20	21	.289	.355	.474	.829
21	Brian Downing B. Downing	98	156	524	155	27	2	26	95	95	19	80	4	3	652	264	55	6	8	8	15	.296	.416	.504	.920
22	Dwight Evans D. Evans	98	168	610	176	33	5	28	94	102	3	135	11	3	725	303	66	8	2	6	11	.289	.392	.497	.889
23	Eric Chavez E. Chavez	95	157	559	153	27	1	30	89	76	2	114	4	0	642	272	58	0	5	5	14	.274	.360	.487	.846
24	Gary Gaetti G. Gaetti	93	167	621	167	32	5	30	105	43	5	119	4	6	676	299	67	1	6	3	16	.269	.319	.481	.800
25	Vladimir Guerrero V. Guerrero	92	120	462	157	31	1	30	95	49	7	49	2	1	522	280	62	0	4	15	9	.340	.408	.606	1.014

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StatMuse has game-level data for runs going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Astros	87	75	.537	3.0
Rangers	81	81	.500	9.0
Athletics	76	86	.469	14.0
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DATE	MATCHUP			TIME (ET)
Thu 3/26	LAA	@	HOU	4:10 PM
Fri 3/27	LAA	@	HOU	8:10 PM
Sat 3/28	LAA	@	HOU	7:10 PM
Sun 3/29	LAA	@	HOU	2:10 PM
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Phillies - y	96	66	.593
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Marlins	79	83	.488	17.0
Braves	76	86	.469	20.0
Nationals	66	96	.407	30.0
NL Central	W	L	PCT	GB
Brewers - y	97	65	.599
Cubs - w	92	70	.568	5.0
Reds - w	83	79	.512	14.0
Cardinals	78	84	.481	19.0
Pirates	71	91	.438	26.0
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Dodgers - y	93	69	.574
Padres - w	90	72	.556	3.0
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Yankees - w	94	68	.580
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Twins	70	92	.432	18.0
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Mariners - y	90	72	.556
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Tue 9/16	CIN	@	STL	6-2
Tue 9/16	ATL	@	WSH	9-4
Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
Tue 9/16	SEA	@	KCR	5-7

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DATE	MATCHUP			TIME (ET)
Wed 3/25	NYY	@	SFG	8:05 PM
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Mike Trout has scored the most career runs against the Mariners, with 149 runs.

Interpreted as:

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