Cade Smith pitched in the most games for the Guardians in 2025, with 76 games.

	NAME	G	SEASON	TM	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Cade Smith C. Smith	76	2025	CLE	8	5	.615	0	2.93	104	0	0	16	73.2	55	24	31	4	19	4	30	3	300	3	12.71	2.32	5.47	0.49	34.7	6.3	1.00	.302	3.79	72	1.95	47	6.72	18
2	Hunter Gaddis H. Gaddis	73	2025	CLE	2	2	.500	0	3.10	73	0	0	3	66.2	58	23	24	8	21	1	8	2	274	2	9.86	2.84	3.48	1.08	26.6	7.7	1.18	.292	3.24	77	3.49	84	7.83	4.8
3	Matt Festa M. Festa	63	2025	CLE	5	4	.556	0	4.12	56	0	0	0	54.2	44	25	29	4	15	5	5	2	226	1	9.22	2.47	3.73	0.66	24.8	6.6	1.08	.274	4.77	102	3.13	76	7.24	6.1
4	Jakob Junis J. Junis	57	2025	CLE	4	1	.800	0	2.97	55	0	0	0	66.2	64	22	24	5	18	4	9	2	274	0	7.43	2.43	3.06	0.68	20.1	6.6	1.23	.307	3.24	73	3.44	83	8.64	5.1
5	Tim Herrin T. Herrin	54	2025	CLE	5	4	.556	0	4.85	45	0	0	0	42.2	37	23	23	5	30	6	4	2	194	2	9.49	6.33	1.50	1.05	23.2	15.5	1.57	.296	4.85	120	5.07	123	7.80	-4.5
6	Emmanuel Clase E. Clase	48	2025	CLE	5	3	.625	0	3.23	47	0	0	24	47.1	46	17	20	2	12	4	41	2	201	4	8.94	2.28	3.92	0.38	23.4	6.0	1.23	.324	3.80	80	2.71	66	8.75	7.5
7	Joey Cantillo J. Cantillo	34	2025	CLE	5	3	.625	13	3.21	108	0	0	1	95.1	78	34	39	10	42	0	10	0	401	2	10.20	3.97	2.57	0.94	26.9	10.5	1.26	.282	3.68	79	3.55	86	7.36	6.2
8	Kolby Allard K. Allard	33	2025	CLE	2	2	.500	2	2.63	42	0	0	0	65.0	64	19	22	5	14	1	16	3	266	0	5.82	1.94	3.00	0.69	15.8	5.3	1.20	.289	3.05	65	3.53	85	8.86	4.4
9	Erik Sabrowski E. Sabrowski	33	2025	CLE	0	1	.000	0	1.84	42	0	0	0	29.1	14	6	8	2	21	3	3	0	121	0	12.89	6.44	2.00	0.61	34.7	17.4	1.19	.226	2.45	45	3.61	87	4.30	1.7
10	Gavin Williams G. Williams	31	2025	CLE	12	5	.706	31	3.06	173	0	0	0	167.2	130	57	62	23	83	3	0	0	704	9	9.29	4.46	2.08	1.23	24.6	11.8	1.27	.254	3.33	76	4.39	106	6.98	-4.9
11	Tanner Bibee T. Bibee	31	2025	CLE	12	11	.522	31	4.24	162	2	1	0	182.1	170	86	93	27	54	10	0	1	762	3	8.00	2.67	3.00	1.33	21.3	7.1	1.23	.281	4.59	105	4.33	105	8.39	-4.2
12	Logan Allen L. Allen	30	2025	CLE	8	11	.421	29	4.25	122	0	0	0	156.2	157	74	84	18	62	6	0	1	676	4	7.01	3.56	1.97	1.03	18.0	9.2	1.40	.297	4.83	105	4.37	106	9.02	-4.2
13	Nic Enright N. Enright	27	2025	CLE	2	1	.667	0	2.03	30	0	0	1	31.0	24	7	8	3	12	2	8	0	127	0	8.71	3.48	2.50	0.87	23.6	9.4	1.16	.263	2.32	50	3.81	92	6.97	1.1
14	Slade Cecconi S. Cecconi	23	2025	CLE	7	7	.500	23	4.30	109	0	0	0	132.0	125	63	66	24	32	3	0	1	545	3	7.43	2.18	3.41	1.64	20.0	5.9	1.19	.268	4.50	106	4.64	112	8.52	-7.6
15	Paul Sewald P. Sewald	18	2025	CLE	1	1	.500	0	4.70	18	0	0	2	15.1	14	8	9	3	4	0	3	0	62	0	10.57	2.35	4.50	1.76	29.0	6.5	1.17	.297	5.28	116	4.11	99	8.22	0
16	Luis L. Ortiz L. L. Ortiz	16	2025	CLE	4	9	.308	16	4.36	96	0	0	0	88.2	80	43	44	12	42	1	0	0	382	0	9.74	4.26	2.29	1.22	25.1	11.0	1.38	.294	4.47	108	4.18	101	8.12	-0.5
17	Zak Kent Z. Kent	12	2025	CLE	1	0	1.000	0	4.58	16	0	0	0	17.2	17	9	10	1	8	1	11	0	76	3	8.15	4.08	2.00	0.51	21.1	10.5	1.42	.320	5.09	113	3.58	87	8.66	1.1
18	Ben Lively B. Lively	9	2025	CLE	2	2	.500	9	3.22	29	0	0	0	44.2	38	16	16	6	15	0	0	0	178	0	5.84	3.02	1.93	1.21	16.3	8.4	1.19	.250	3.22	80	4.58	111	7.66	-2.3
19	Parker Messick P. Messick	7	2025	CLE	3	1	.750	7	2.72	38	0	0	0	39.2	46	12	12	4	6	0	0	0	165	2	8.62	1.36	6.33	0.91	23.0	3.6	1.31	.359	2.72	67	2.98	72	10.44	5.1
20	Carlos Hernández C. Hernández	5	2025	CLE	0	0		0	3.86	3	0	0	0	7.0	4	3	3	0	3	0	4	0	27	1	3.86	3.86	1.00	0.00	11.1	11.1	1.00	.190	3.86	95	3.56	86	5.14	0.4
21	Triston McKenzie T. McKenzie	4	2025	CLE	0	0		0	11.12	4	0	0	0	5.2	7	7	7	1	7	0	3	0	30	3	6.35	11.12	0.57	1.59	13.3	23.3	2.47	.333	11.12	275	7.72	187	11.12	-2.3
22	Austin Hedges A. Hedges	3	2025	CLE	0	0		0	6.00	1	0	0	0	3.0	6	2	2	0	1	0	3	0	16	0	3.00	3.00	1.00	0.00	6.3	6.3	2.33	.429	6.00	148	3.46	84	18.00	0.2
23	Doug Nikhazy D. Nikhazy	2	2025	CLE	0	1	.000	1	13.50	5	0	0	0	4.0	5	6	6	0	6	0	1	0	23	1	11.25	13.50	0.83	0.00	21.7	26.1	2.75	.417	13.50	334	5.13	124	11.25	-0.4
24	Andrew Walters A. Walters	2	2025	CLE	0	0		0	13.50	2	0	0	0	1.1	2	2	2	1	0	0	0	0	6	0	13.50	0.00		6.75	33.3	0.0	1.50	.333	13.50	334	9.88	239	13.50	-0.9
25	Cody Bolton C. Bolton	1	2025	CLE	0	0		0	13.50	1	0	0	0	2.0	4	3	3	0	0	0	0	0	10	0	4.50	0.00		0.00	10.0	0.0	2.00	.444	13.50	334	2.13	52	18.00	0.4