7 pitchers were tied for appearing in the most games by a starting pitcher in 2021, with 33 games. The first three are Marcus Stroman, Walker Buehler and Tyler Mahle.

	NAME	G	SEASON	TM	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Marcus Stroman M. Stroman	33	2021	NYM	10	13	.435	33	3.02	158	0	0	0	179.0	161	60	70	17	44	7	0	2	730	7	7.94	2.21	3.59	0.85	21.6	6.0	1.15	.286	3.52	8.09
2	Walker Buehler W. Buehler	33	2021	LAD	16	4	.800	33	2.47	212	0	0	0	207.2	149	57	61	19	52	6	0	2	815	5	9.19	2.25	4.08	0.82	26.0	6.4	0.97	.247	2.64	6.46
3	Tyler Mahle T. Mahle	33	2021	CIN	13	6	.684	33	3.75	210	0	0	0	180.0	158	75	78	24	64	10	0	0	759	4	10.50	3.20	3.28	1.20	27.7	8.4	1.23	.297	3.90	7.90
4	Charlie Morton C. Morton	33	2021	ATL	14	6	.700	33	3.34	216	0	0	0	185.2	136	69	77	16	58	17	0	1	756	5	10.47	2.81	3.72	0.78	28.6	7.7	1.04	.267	3.73	6.59
5	Sandy Alcantara S. Alcantara	33	2021	MIA	9	15	.375	33	3.19	201	1	0	0	205.2	171	73	85	21	50	10	0	2	837	6	8.80	2.19	4.02	0.92	24.0	6.0	1.07	.270	3.72	7.48
6	Luis Castillo L. Castillo	33	2021	CIN	8	16	.333	33	3.98	192	0	0	0	187.2	181	83	94	19	75	7	0	4	803	1	9.21	3.60	2.56	0.91	23.9	9.3	1.36	.318	4.51	8.68
7	Kevin Gausman K. Gausman	33	2021	SFG	14	6	.700	33	2.81	227	0	0	0	192.0	150	60	66	20	50	4	0	1	775	7	10.64	2.34	4.54	0.94	29.3	6.5	1.04	.274	3.09	7.03
8	Robbie Ray R. Ray	32	2021	TOR	13	7	.650	32	2.84	248	0	0	0	193.1	150	61	62	33	52	4	0	0	773	5	11.54	2.42	4.77	1.54	32.1	6.7	1.04	.268	2.89	6.98
9	Frankie Montas Jr. F. Montas Jr.	32	2021	OAK	13	9	.591	32	3.37	207	0	0	0	187.0	164	70	79	20	57	7	0	1	778	11	9.96	2.74	3.63	0.96	26.6	7.3	1.18	.296	3.80	7.89
10	Dylan Cease D. Cease	32	2021	CWS	13	7	.650	32	3.91	226	1	1	0	165.2	139	72	77	20	68	9	0	0	708	13	12.28	3.69	3.32	1.09	31.9	9.6	1.25	.309	4.18	7.55
11	Zach Davies Z. Davies	32	2021	CHC	6	12	.333	32	5.78	114	0	0	0	148.0	162	95	99	25	75	5	0	2	668	0	6.93	4.56	1.52	1.52	17.1	11.2	1.60	.305	6.02	9.85
12	Sean Manaea S. Manaea	32	2021	OAK	11	10	.524	32	3.91	194	2	2	0	179.1	179	78	79	25	41	9	0	0	754	5	9.74	2.06	4.73	1.25	25.7	5.4	1.23	.318	3.96	8.98
13	Julio Urías J. Urías	32	2021	LAD	20	3	.870	32	2.96	195	0	0	0	185.2	151	61	67	19	38	7	0	3	745	2	9.45	1.84	5.13	0.92	26.2	5.1	1.02	.272	3.25	7.32
14	José Berríos J. Berríos	32	2021	TOT	12	9	.571	32	3.52	204	1	0	0	192.0	159	75	83	22	45	15	0	0	781	3	9.56	2.11	4.53	1.03	26.1	5.8	1.06	.277	3.89	7.45
15	Cole Irvin C. Irvin	32	2021	OAK	10	15	.400	32	4.24	125	0	0	0	178.1	195	84	94	23	42	9	0	0	768	3	6.31	2.12	2.98	1.16	16.3	5.5	1.33	.302	4.74	9.84
16	Adam Wainwright A. Wainwright	32	2021	STL	17	7	.708	32	3.05	174	3	1	0	206.1	168	70	72	21	50	9	0	3	828	4	7.59	2.18	3.48	0.92	21.0	6.0	1.06	.256	3.14	7.33
17	Zack Wheeler Z. Wheeler	32	2021	PHI	14	10	.583	32	2.78	247	3	2	0	213.1	169	66	72	16	46	8	0	1	849	6	10.42	1.94	5.37	0.68	29.1	5.4	1.01	.288	3.04	7.13
18	Nathan Eovaldi N. Eovaldi	32	2021	BOS	11	9	.550	32	3.75	195	0	0	0	182.1	182	76	81	15	35	7	0	2	764	6	9.63	1.73	5.57	0.74	25.5	4.6	1.19	.326	4.00	8.98
19	Kyle Hendricks K. Hendricks	32	2021	CHC	14	7	.667	32	4.77	131	1	0	0	181.0	200	96	101	31	44	13	0	3	785	2	6.51	2.19	2.98	1.54	16.7	5.6	1.35	.299	5.02	9.94
20	Germán Márquez G. Márquez	32	2021	COL	12	11	.522	32	4.40	176	3	1	0	180.0	165	88	92	21	64	4	0	5	756	15	8.80	3.20	2.75	1.05	23.3	8.5	1.27	.293	4.60	8.25
21	Aaron Nola A. Nola	32	2021	PHI	9	9	.500	32	4.63	223	1	1	0	180.2	165	93	95	26	39	9	0	1	749	0	11.11	1.94	5.72	1.30	29.8	5.2	1.13	.308	4.73	8.22
22	Patrick Corbin P. Corbin	31	2021	WSH	9	16	.360	31	5.82	143	0	0	0	171.2	192	111	114	37	60	3	0	2	751	0	7.50	3.15	2.38	1.94	19.0	8.0	1.47	.305	5.98	10.07
23	Eduardo Rodriguez E. Rodriguez	31	2021	BOS	12	8	.600	31	4.77	184	0	0	0	156.2	172	83	87	19	47	2	0	0	672	0	10.57	2.70	3.91	1.09	27.4	7.0	1.40	.364	5.00	9.88
24	Anthony DeSclafani A. DeSclafani	31	2021	SFG	13	7	.650	31	3.17	152	2	2	0	167.2	141	59	61	19	42	2	0	1	676	7	8.16	2.25	3.62	1.02	22.5	6.2	1.09	.265	3.27	7.57
25	Tyler Anderson T. Anderson	31	2021	TOT	7	11	.389	31	4.53	134	0	0	0	167.0	170	84	87	27	38	1	0	2	703	1	7.22	2.05	3.53	1.46	19.1	5.4	1.25	.284	4.69	9.16