Marcus Semien has hit the most homers by a second baseman in a season, with 45 home runs in 2021.

	NAME	HR	SEASON	TM	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Marcus Semien M. Semien	45	2021	TOR	162	652	115	173	39	2	102	66	3	146	15	1	724	351	86	0	3	0	9	.265	.334	.538	.873	120	31.9	.368	131	27.4
2	Davey Johnson D. Johnson	43	1973	ATL	157	559	84	151	25	0	99	81	9	93	5	3	651	305	68	0	2	9	8	.270	.370	.546	.916	114	42.1	.404	146	34.7
3	Brian Dozier B. Dozier	42	2016	MIN	155	615	104	165	35	5	99	61	8	138	18	2	691	336	82	2	5	6	12	.268	.340	.546	.886	111	29.5	.370	132	26.3
4	Rogers Hornsby R. Hornsby	42	1922	SLN	154	623	141	250	46	14	152	65	1	50	17	12	704	450	102	15				.401	.459	.722	1.181	186	97.8	.520	197	92.7
5	Ryne Sandberg R. Sandberg	40	1990	CHC	155	615	116	188	30	3	100	50	1	84	25	7	675	344	73	0	9	8	8	.306	.354	.559	.913	116	40.3	.396	142	33.3
6	Brandon Lowe B. Lowe	39	2021	TBR	149	535	97	132	31	0	99	68	9	167	7	1	615	280	70	0	3	4	2	.247	.340	.523	.863	99	24.9	.363	137	27.8
7	Robinson Cano R. Cano	39	2016	SEA	161	655	107	195	33	2	103	47	8	100	0	1	715	349	74	0	5	8	18	.298	.350	.533	.882	115	30.7	.370	139	33.3
8	Alfonso Soriano A. Soriano	39	2002	NYY	156	696	128	209	51	2	102	23	14	157	41	13	741	381	92	1	7	1	8	.300	.332	.547	.880	118	29.2	.374	131	27.9
9	Rogers Hornsby R. Hornsby	39	1929	CHC	156	602	156	229	47	8	149	87	1	65	2		712	409	94	22				.380	.459	.679	1.139	181	86.8	.497	174	77.3
10	Rogers Hornsby R. Hornsby	39	1925	SLN	138	504	133	203	41	10	143	83	2	39	5	3	605	381	90	16				.403	.489	.756	1.245	173	94.1	.540	208	90.1
11	Alfonso Soriano A. Soriano	38	2003	NYY	156	682	114	198	36	5	91	38	12	130	35	8	734	358	79	0	2	7	8	.290	.338	.525	.863	113	23.1	.365	124	22.1
12	Jay Bell J. Bell	38	1999	ARI	151	589	132	170	32	6	112	82	4	132	7	4	688	328	76	4	9	2	9	.289	.374	.557	.931	122	32.3	.395	129	26.8
13	Jeff Kent J. Kent	37	2002	SFG	152	623	102	195	42	2	108	52	4	101	5	1	682	352	81	0	3	3	20	.313	.368	.565	.933	122	40.2	.397	147	40.1
14	Bret Boone B. Boone	37	2001	SEA	158	623	118	206	37	3	141	40	9	110	5	5	690	360	77	5	13	5	11	.331	.372	.578	.950	126	40.5	.397	149	42.5
15	Ketel Marte K. Marte	36	2024	ARI	136	504	93	147	23	2	95	65	5	106	7	1	583	282	61	0	9	7	9	.292	.372	.560	.932	106	37.9	.391	151	35.7
16	Dan Uggla D. Uggla	36	2011	ATL	161	600	88	140	22	1	82	62	7	156	1	3	672	272	59	0	3	2	9	.233	.311	.453	.764	85	9.4	.334	110	8
17	Aaron Hill A. Hill	36	2009	TOR	158	682	103	195	37	0	108	42	5	98	6	2	734	340	73	1	4	1	17	.286	.330	.499	.829	105	17.1	.357	115	13.4
18	Alfonso Soriano A. Soriano	36	2005	TEX	156	637	102	171	43	2	104	33	7	125	30	2	682	326	81	0	5	3	6	.268	.309	.512	.821	94	12.2	.347	108	6.6
19	Max Muncy M. Muncy	35	2019	LAD	141	487	101	122	22	1	98	90	8	149	4	1	589	251	58	0	4	1	5	.251	.374	.515	.889	101	26.8	.372	133	25.4
20	Bret Boone B. Boone	35	2003	SEA	159	622	111	183	35	5	117	68	7	125	16	3	705	333	75	1	7	3	17	.294	.366	.535	.902	119	32.9	.384	140	35.4
21	Javier Báez J. Báez	34	2018	CHC	160	606	101	176	40	9	111	29	5	167	21	9	645	336	83	1	4	8	10	.290	.326	.554	.881	103	27.2	.366	131	24.6
22	Brian Dozier B. Dozier	34	2017	MIN	152	617	106	167	30	4	93	78	8	141	16	7	705	307	68	0	2	6	11	.271	.359	.498	.856	110	24.4	.362	126	22.5
23	Ozzie Albies O. Albies	33	2023	ATL	148	596	96	167	30	5	109	46	8	107	13	1	658	306	68	0	8	2	9	.280	.336	.513	.849	102	21.8	.358	124	19.7
24	Jorge Polanco J. Polanco	33	2021	MIN	152	588	97	158	35	2	98	45	5	118	11	6	644	296	70	0	6	0	4	.269	.323	.503	.826	97	18.5	.349	123	18.4
25	Rougned Odor R. Odor	33	2016	TEX	150	605	89	164	33	4	88	19	4	135	14	7	632	304	70	0	4	0	6	.271	.296	.502	.798	84	9.3	.336	103	1.9