The Seattle Mariners had their most runs in a game against the Tigers on April 29, 1999, with 22 runs.

Interpreted as:

most mariners runs in a regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mariners	22	4/29/1999	SEA	vs	DET	W 22-6	43	19	5	0	4	22	8	2	5	1	0	54	36	9	0	1	0	0	.442	.537	.837	1.374
2	Mariners	21	5/30/2012	SEA	@	TEX	W 21-8	47	20	7	0	4	20	6	0	8	1	0	54	39	11	0	1	0	0	.426	.481	.830	1.311
3	Mariners	21	9/30/2000	SEA	@	ANA	W 21-9	46	22	4	1	5	20	11	0	9	2	1	59	43	10	1	1	0	0	.478	.569	.935	1.504
4	Mariners	19	4/16/2000	SEA	@	TOR	W 19-7	47	22	5	1	5	19	6	2	8	0	1	55	44	11	0	0	0	0	.468	.545	.936	1.482
5	Mariners	19	6/28/1996	SEA	vs	TEX	W 19-8	46	22	3	2	3	17	6	1	7	0	0	53	38	8	0	0	0	0	.478	.547	.826	1.373
6	Mariners	19	5/20/1994	SEA	vs	TEX	W 19-2	42	21	6	0	5	19	2	0	6	1	0	46	42	11	1	1	1	0	.500	.511	1.000	1.511
7	Mariners	18	9/7/2025	SEA	@	ATL	W 18-2	45	19	1	1	5	14	3	2	7	2	0	51	37	7	0	1	0	1	.422	.471	.822	1.293
8	Mariners	18	7/17/1998	SEA	vs	KCR	W 18-5	41	22	3	0	3	18	5	0	3	1	0	48	34	6	0	2	0	2	.537	.563	.829	1.392
9	Mariners	18	6/11/1996	SEA	@	MIN	W 18-8	50	24	7	0	1	16	3	1	7	0	0	55	34	8	0	1	0	1	.480	.509	.680	1.189
10	Mariners	17	4/15/2000	SEA	@	TOR	W 17-6	44	16	4	0	3	15	7	1	5	1	0	53	29	7	0	1	0	0	.364	.453	.659	1.112
11	Mariners	16	9/4/2024	SEA	@	OAK	W 16-3	42	16	7	0	1	16	4	1	6	1	0	48	26	8	0	1	0	0	.381	.438	.619	1.057
12	Mariners	16	6/2/2016	SEA	@	SDP	W 16-13	43	16	1	0	2	16	2	1	8	1	0	46	23	3	0	0	0	0	.372	.413	.535	.948
13	Mariners	16	5/31/2016	SEA	vs	SDP	W 16-4	37	14	0	0	5	16	10	1	4	0	0	48	29	5	0	0	0	1	.378	.521	.784	1.305
14	Mariners	16	9/22/2004	SEA	@	ANA	W 16-6	47	24	3	0	0	16	5	0	5	0	1	56	27	3	1	3	1	0	.511	.527	.574	1.102
15	Mariners	16	8/17/2004	SEA	@	KCR	W 16-3	47	20	3	1	3	15	4	3	9	0	0	54	34	7	0	0	0	1	.426	.500	.723	1.223
16	Mariners	16	9/8/2002	SEA	@	KCR	W 16-9	47	15	4	0	4	16	7	2	6	2	0	57	31	8	1	0	2	1	.319	.429	.660	1.088
17	Mariners	16	4/22/2002	SEA	vs	ANA	W 16-5	42	18	2	1	5	16	7	0	7	0	0	50	37	8	0	1	1	0	.429	.500	.881	1.381
18	Mariners	16	10/4/2001	SEA	vs	TEX	W 16-1	43	19	6	0	1	16	6	1	8	2	0	50	28	7	0	0	0	0	.442	.520	.651	1.171
19	Mariners	16	8/22/2001	SEA	vs	DET	W 16-1	42	20	5	1	4	15	4	1	5	0	0	47	39	10	0	0	0	2	.476	.532	.929	1.460
20	Mariners	16	5/17/1993	SEA	@	TEX	W 16-9	46	23	3	0	3	15	1	1	7	0	0	51	35	6	2	1	1	0	.500	.510	.761	1.271
21	Mariners	16	7/11/1979	SEA	vs	NYY	W 16-1	40	16	2	1	3	16	8	1	6	0	0	49	29	6	0	0	0	0	.400	.510	.725	1.235
22	Mariners	15	7/12/2025	SEA	@	DET	W 15-7	44	19	5	0	3	15	4	1	10	2	1	50	33	8	0	1	0	0	.432	.480	.750	1.230
23	Mariners	15	8/26/2023	SEA	vs	KCR	W 15-2	37	13	1	0	7	15	7	1	7	0	0	45	35	8	0	0	0	0	.351	.467	.946	1.413
24	Mariners	15	5/21/2010	SEA	vs	SDP	W 15-8	40	15	3	0	3	15	4	0	8	0	0	45	27	6	0	1	0	0	.375	.422	.675	1.097
25	Mariners	15	5/4/2007	SEA	@	NYY	W 15-11	45	20	6	0	3	15	4	1	3	0	0	50	35	9	0	0	0	2	.444	.500	.778	1.278